The involvement of tachykinin NK2 and NK3 receptors in central sensitization of a spinal withdrawal reflex in the decerebrated, spinalized rabbit

Neuropharmacology

Volumn 39, Issue 1, 2000, Pages 133-140

  Houghton, Andrea K ^a   Ogilvie, Jane ^a   Clarke, Rob W ^a  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

Neurokinin A; Neurokinin B; Nociception; Substance P; Tachykinins; Withdrawal reflex

Indexed keywords

NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; OSANETANT; SAREDUTANT; BENZAMIDE DERIVATIVE; PIPERIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; GASTROCNEMIUS MUSCLE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SENSITIZATION; SPINAL CORD; SURAL NERVE; WITHDRAWAL REFLEX; ANIMAL; BLOOD PRESSURE; DECEREBRATION; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSTIMULATION; INNERVATION; MOTONEURON; MYELINATED NERVE; PHYSIOLOGY; REFLEX; SKELETAL MUSCLE;

ANIMALS; BENZAMIDES; BLOOD PRESSURE; DECEREBRATE STATE; ELECTRIC STIMULATION; FEMALE; MALE; MOTOR NEURONS; MUSCLE, SKELETAL; NERVE FIBERS, MYELINATED; PIPERIDINES; RABBITS; RECEPTORS, NEUROKININ-2; RECEPTORS, NEUROKININ-3; REFLEX; SPINAL CORD; SURAL NERVE;

EID: 0033622175     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00072-6     Document Type: Article

References (59)

1. 2) receptor revisited with SR 48968, a potent non-peptide antagonist. Biochem. Biophys. Res. Comm., 184, 1418-1424.
2. 3 receptors. Biochem. Biophys. Res. Comm. 198:1994;967-972.
3. Clarke R.W., Ford T.W. The contributions of μ-, δ- and κ-opioid receptors to the actions of endogenous opioids on spinal reflexes in the rabbit. Br. J. Pharmacol. 91:1987;579-589.
4. Clarke R.W., Harris J., Ford T.W., Taylor J.S. Prolonged potentiation of transmission through a withdrawal reflex pathway after noxious stimulation of the heel in the rabbit. Pain. 49:1992;65-70.
5. 3 tachykinin receptors in central sensitization of a withdrawal reflex in the rabbit. Soc. Neurosci. Abstracts. 24:1998;1865.
6. Cleland C.L., Gebhart G.F. Does central nervous system plasticity contribute to hyperalgesia? Behav. Brain Sci. 20:1997;444-445.
7. Coderre T.J., Katz J. Peripheral and central hyperexcitability: differential signs and symptoms in persistent pain. Behav. Brain Sci. 20:1997;404-419.
8. Coderre T.J., Katz J. What exactly is central to the role of central neuroplasticity in persistent pain? Behav. Brain Sci. 20:1997;483-486.
9. Couture R., Picard P., Poulat P., Prat A. Characterization of the tachykinin receptors involved in spinal and supraspinal cardiovascular regulation. Can. J. Physiol. Pharmacol. 73:1995;892-902.
10. 1A receptor-binding autoradiography. J. Comp. Neurol. 361:1995;633-644.
11. Cumberbatch M.J., Chizh B.A., Headley P.M. Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord. Br. J. Pharmacol. 115:1995;1005-1012.
12. 3) in the central nervous system of the rat. J. Comp. Neurol. 364:1996;290-310.
13. Dougherty P.M., Palecek J., Paleckova V., Willis W.D. Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin. J. Neurophysiol. 72:1994;1464-1475.
14. Duggan A.W., Hope P.J., Jarrott B., Schaible H.G., Fleetwood-Walker S.M. Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious stimulation studies with antibody microprobes. Neuroscience. 35:1990;195-202.
15. 3 receptor. Life Sci. 56:1994;PL27-PL202.
16. 2) receptor. Life Sci., 50, PL101-PL106.
17. Fleetwood-Walker S.M., Mitchell R., Hope P.J., El-Yassir N., Molony V., Bladon C.M. The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat. Brain Res. 519:1990;169-182.
18. Hokfelt T., Ljungdahl A., Terenius L., Elde R., Nilsson G. Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proceed. Nat. Acad. Sci. USA. 74:1977;3081-3085.
19. 1-tachykinin receptors and prolonged, stimulus-evoked alterations in the excitability of withdrawal reflexes in the decerebrated and spinalized rabbit. Neuroscience. 66:1995;673-683.
20. 2-tachykinin receptors and prolonged, stimulus-evoked facilitation of a withdrawal reflex in the decerebrated and spinalized rabbit. J. Physiol. 483:1995;153P.
21. 2 receptors contribute to the increased excitability of the nociceptive flexor reflex during persistent peripheral inflammation. Brain Res. 751:1997;169-174.
22. Laird J.M.A., Hargreaves R.J., Hill R.G. Effect of RP 67580, a non-peptide neurokinin1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the rat. Br. J. Pharmacol. 109:1993;713-718.
23. Light A.R. Spinal terminations of nociceptive primary afferent axons. Light A.R. The Initial Processing of Pain and its Descending Control: Spinal and Trigeminal Systems. 1992;87-108 Karger, Basel.
24. Lin Q., Peng Y.B., Wu J., Willis W.D. Involvement of cGMP in nociceptive processing by and sensitization of spinothalamic neurons in primates. J. Neurosci. 17:1997;3293-3302.
25. Liu X.G., Sandkuhler J. Activation of spinal N-methyl-D-aspartate or neurokinin receptors induces long-term potentiation of spinal C-fibre-evoked potentials. Neuroscience. 86:1998;1209-1216.
26. 2+ channels. Eur. J. Pharmacol. 267:1994;113-115.
27. Ma Q.P., Woolf C.J. Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurones. J. Physiol. 486:1995;769-777.
28. Ma Q.P., Woolf C.J. Noxious stimuli induce an N-methyl-D-aspartate receptor-dependent hypersensitivity of the flexion withdrawal reflex to touch-implications for the treatment of mechanical allodynia. Pain. 61:1995;383-390.
29. Maggi C.A. The mammalian tachykinin receptors. Gen. Pharmacol. 26:1995;911-944.
30. 1 receptor. Trends Pharmacol. Sci. 18:1997;351-355.
31. Martin C.A.E., Emonds-Alt X., Advenier C. Inhibition of cholinergic neurotransmission in isolated guinea-pig main bronchi by SR 48968. Eur. J. Pharmacol. 243:1993;309-312.
32. 3 type tachykinin receptor messenger-RNA expression in the rat spinal-cord dorsal horn is increased during adjuvant or formalin-induced nociception. J. Neurosci. 14:1994;712-720.
33. McMahon S.B., Lewin G.R., Wall P.D. Central hyperexcitability triggered by noxious inputs. Curr. Opin. Neurobiol. 3:1993;602-610.
34. 3 receptor antagonists. Br. J. Pharmacol. 122:1997;469-476.
35. Moussaoui S.M., Leprado N., Bonici B., Faucher D.C., Cuine F., Laduron P.M., Garret C. Distribution of neurokinin B in rat spinal-cord and peripheral-tissues-comparison with neurokinin A and substance P and effects of neonatal capsaicin treatment. Neuroscience. 48:1992;969-978.
36. Nakanishi S. Substance P precursor and kininogen: their structures, gene organizations, and regulation. Physiol. Rev. 67:1987;1117-1142.
37. Nguyenle X.K., Nguyen Q.T., Gobeil F., Pheng L.H., Emonds-Alt X., Breliere J.C., Regoli D. Pharmacological characterization of SR-142801 - A new nonpeptide antagonist of the neurokinin NK-3 receptor. Pharmacology. 52:1996;283-291.
38. Petitet F., Beaujouan J.C., Saffroy M., Torrens Y., Glowinski J. The nonpeptide NK-2 antagonist SR 48968 is also a NK-3 antagonist in the guinea pig but not in the rat. Biochem. Biophys. Res. Commun. 191:1993;180-187.
39. Picard P., Regoli D., Couture R. Cardiovascular and behavioural effects of centrally administered tachykinins in the rat: characterization of receptors with selective antagonists. Br. J. Pharmacol. 112:1994;240-249.
40. Poncelet M., Guedet C., Emonds-Alt X., Breliere J.C., Le Fur G., Soubrie P. Turning behavior induced in mice by a neurokinin A receptor agonist: stereoselective blockade by SR 48968, a non-peptide receptor antagonist. Neurosci. Lett. 149:1993;40-42.
41. 3 receptor antagonist on cardiovascular responses in conscious guinea-pig. Br. J. Pharmacol. 118:1996;1095-1102.
42. Routh V.H., Helke C.J. Tachykinin receptors in the spinal cord. Progress Brain Res. 104:1994;93-108.
43. Sakurada T., Manome Y., Katsumata K., Uchiumi H., Tanno K., Sakurada S., Kisara K. Naloxone-reversible effect of spantide on the spinally mediated behavioral-response induced by neurokinin-2 and neurokinin-3 receptor agonists. Naunyn-Schmiedebergs Arch. Pharmacol. 346:1992;69-75.
44. Santos A.R.S., Calixto J.B. Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice. Neuropeptides. 31:1997;381-389.
45. 2 receptor antagonist SR48968 inhibits thalamic responses evoked by thermal but not mechanical nociception. Eur. J. Pharmacol. 237:1993;143-146.
46. Schaible H.G. On the role of tachykinins and calcitonin gene-related peptide in the spinal mechanisms of nociception and in the induction and maintenance of inflammation-evoked hyperexcitability in spinal cord neurons (with special reference to nociception in joints). Progress Brain Res. 113:1996;423-441.
47. 3 receptor-immunoreactivity to subpopulations of neurons in rat spinal cord. J. Comp. Neurol. 381:1997;439-448.
48. 1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in the rat spinal cord in vitro. J. Neurosci. 14:1994;3672-3687.
49. Todd A.J., Spike R.C. The localization of classical transmitters and neuropeptides within neurons in laminae I-III of the mammalian spinal dorsal horn. Prog. Neurobiol. 41:1993;609-645.
50. Too H.P., Maggio J.E. Immunocytochemical localization of neuromedin K (neurokinin B) in rat spinal ganglia and cord. Peptides. 12:1991;431-443.
51. Wall P.D., Woolf C.J. Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat. J. Physiol. 356:1984;443-458.
52. Wang Z.Y., Tung S.R., Strichartz G.R., Hakanson R. Non-specific actions of the non-peptide tachykinin receptor antagonists, CP-96,345, RP 67580 and SR 48968, on neurotransmission. Br. J. Pharmacol. 111:1994;179-184.
53. 2 receptor antagonists in rat spinal cord. Eur. J. Pharmacol. 251:1994;99-102.
54. Woolf C.J., Thompson S.W.N. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation-implications for the treatment of post-injury pain hypersensitivity states. Pain. 44:1991;293-299.
55. Woolf C.J., Wall P.D. Relative effectiveness of C primary afferent fibres of different origins in evoking a prolonged facilitation of the flexor reflex in the rat. J. Neurosci. 6:1986;1433-1442.
56. Xu X.J., Maggi C.A., Wiesenfeld-Hallin Z. On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat. Neuroscience. 44:1991;483-490.
57. Yamamoto T., Shimoyama N., Mizuguchi T. Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw. Anesth. Analgesia. 77:1993;886-890.
58. Zerari F., Karpitskiy V., Krause J., Descarries L., Couture R. Immunoelectron microscopic localization of NK-3 receptor in the rat spinal cord. Neuroreport. 8:1997;2661-2664.
59. Zerari F., Karpitskiy V., Krause J., Descarries L., Couture R. Astroglial distribution of neurokinin-2 receptor immunoreactivity in the rat spinal cord. Neuroscience. 84:1998;1233-1246.