Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: A study using ornithine decarboxylase-overexpressing transgenic rats

European Journal of Neuroscience

Volumn 10, Issue 6, 1998, Pages 2046-2055

  Lukkarinen, Jouko A ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Brain; Diffusion; Ischaemia; Magnetic resonance imaging; Ornithine decarboxylase; Polyamines; Spin spin relaxation

Indexed keywords

EFLORNITHINE; ORNITHINE DECARBOXYLASE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN EDEMA; BRAIN ISCHEMIA; CONTROLLED STUDY; CORPUS STRIATUM; DIFFUSION; ENZYME ACTIVATION; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; STROKE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BODY WATER; BRAIN; CEREBRAL INFARCTION; EFLORNITHINE; ENZYME ACTIVATION; ENZYME INHIBITORS; GASES; HYDROGEN-ION CONCENTRATION; ISCHEMIC ATTACK, TRANSIENT; MAGNETIC RESONANCE IMAGING; ORNITHINE DECARBOXYLASE; RATS;

EID: 0031844346     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1998.00216.x     Document Type: Article

References (3)

1. Alhonen, L., Halmekytö, M., Kosma, V.-M., Wahlfors, J., Kauppinen, R. & Jänne, J. (1995) Life-long over-expression of ornithine decarboxylase (ODC) gene in transgenic mice does not lead to generally enhanced tumorigenesis or neuronal degeneration. Int. J. Cancer, 63, 402-104.
2. Barnett, H.J.M., Eliasziw, M. & Meldrum, H.E. (1995) Drug therapy: Drugs and surgery in the prevention of ischemie stroke. N. Engl. J. Med., 332, 238-248.
3. Bartholeyns, J. & Koch-Weser, J. (1981) Effects of alpha-difluromethylornithine alone and combined with adriamycin or vindesine on L1210 leukemia mice, EMT6 solid tumors in mice, and solid tumors induced by injection of hepatoma tissue culture cells in rats. Cancer Res., 41,5158-5161.