TGF-β1 drives and accelerates erythroid differentiation in the Epo-dependent UT-7 cell line even in the absence of erythropoietin

Experimental Hematology

Volumn 28, Issue 3, 2000, Pages 256-266

  Zermati, Yael ^a   Varet, Bruno ^a,b   Hermine, Olivier ^a,b  

^a CNRS   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Cell cycle; Epo receptor; Erythroid differentiation; Erythropoiesis; Hemoglobin synthesis; TGF 1

Indexed keywords

ERYTHROPOIETIN RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOGLOBIN A; RECOMBINANT ERYTHROPOIETIN; STEM CELL FACTOR; TRANSFORMING GROWTH FACTOR BETA1; ERYTHROPOIETIN; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ERYTHROPOIESIS; HEMOGLOBIN SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; CELL CULTURE; DRUG EFFECT; ERYTHROBLAST; PATHOLOGY;

CELL DIFFERENTIATION; ERYTHROBLASTS; ERYTHROPOIESIS; ERYTHROPOIETIN; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0033621807     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(99)00155-1     Document Type: Article

References (56)

1. Gregory C.J., Eaves A.C. Three stages of erythropoietic progenitor cell differentiation distinguished by a number of physical and biologic properties. Blood. 51:1978;527.
2. Krantz S.B. Erythropoietin. Blood. 77:1991;419.
3. Kurnit D.M., Matthysse S., Papayannopoulou T., Stamatoyannopoulos G. Stochastic branching model for hemopoietic progenitor cell differentiation. J Cell Physiol. 123:1985;55.
4. Ogawa M, Mosmann TR (1985) Two stochastic models for stem cell differentiation. In RP Gale, DE Golde (eds): Leukemia: recent advances in biology and treatment. Los Angeles, CA: UCLA Symposium on Molecular and Cellular Biology, New Series; 28:391.
5. Till J.E., McCulloch E.A., Siminovitch L. A stochastic model of stem cell proliferation based on the growth of spleen colony forming cells. Proc Natl Acad Sci U S A. 51:1964;29.
6. Metcalf D. The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature. 339:1989;27.
7. Krosl J., Damen J.E., Krystal G., Humphries R.K. Erythropoietin and interleukin-3 induce distinct events in erythropoietin recptor-expressing BA/F3 cells. Blood. 85:1995;50.
8. Metcalf D (1984) The hemopoietic colony-stimulating factors. New York: Elsevier Science.
9. Nicola N. Hemopoietic cell growth factors and their receptors. Ann Rev Biochem. 58:1989;45.
10. Migliaccio G., Migliaccio A.R., Visser J.W.M. Synergism between erythropoietin and interleukin-3 in the induction of hematopoietic stem cell proliferation and erythroid burst colony formation. Blood. 72:1988;944.
11. McNiece I.K., Langley K.E., Zsebo K.M. Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and Epo to stimulate human progenitor cells of the myeloid and erythroid lineages. Exp Hematol. 19:1991;226.
12. Broxmeyer H., Williams D., Lu l Cooper S., Anderson S., Beyer G., Hoffman R., Rubin B. The suppressive influence of human tumor necrosis factor on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia. synergism of tumor necrosis factor and interferon-γ J Immunol. 136:1986;4487.
13. Broxmeyer H., Lu l Platzer E., Feit C., Juliano L., Rubin B. Comparative analysis of human gamma, alpha and beta interferon on human multipotential (CFU-GEMM) progenitor cells. J Immunol. 131:1983;1300.
14. Sing G., Keller J., Ellingworth L., Ruscetti F. Transforming growth factor β selectively inhibits normal and leukemic human bone marrow cell growth in vitro. Blood. 72:1988;1504.
15. Hino M., Tojo A., Myiazono K., Urabe A., Takaku F. Effects of type β transforming growth factors on haematopoietic progenitor cells. Br J Haematol. 70:1988;143.
16. Moshe H., Tucker R., Leof E., Coffey R., Halper J., Shipley G. Type beta transforming growth factor is a growth stimulator and a growth inhibitor. Cancer Cells. 3:1985;65.
17. Roberts A, Sporn M: Sporn MB, Roberts AB (1990) Peptide growth factors and their receptors. I. Berlin: Springer.
18. Derynck R., Jarrett J., Chen E., Goeddel D. The murine transforming growth factor-beta precursor. J Biol Chem. 261:1986;4377.
19. Roberts A., Flanders K., Kondaiah P., Thompson N., Van Obberghen-Schilling E., Wakefield L., Rossi P., De Crombrugghe B., Heine U., Sporn M. Transforming growth factor beta. biochemistry and roles in embryogenesis, tissue repair and remodeling, and carcinogenesis Rec Prog Horm Res. 44:1988;157.
20. Massagué J., Cheifetz S., Laiho M., Ralph D., Weis F., Zentella A. Transforming growth factor-β Cancer Surv. 12:1992;81.
21. Massagué J., Attisiano L., Wrana J. The TGF-β family and its composite receptors. Trends Cell Biol. 4:1994;172.
22. Flanders K., Thompson N., Cissel D., Ellingsworth L., Sporn M., Roberts A. Epitope dependent immunolocalization of transforming growth factor β J Cell Biol. 108:1989;653.
23. Wilcox J.R.D. Developmental expression of transforming growth factors α and β in mouse fetus. Mol Cell Biol. 8:1988;3415.
24. Solberg L, Tucker R, Grant B, Mann K, Moses H (1987) Transforming growth factor-β inhibits colony formation from human megakaryocytic, erythroid and multipotent stem cells. In Najman A, Guigon M (eds.): Inhibitors of hematopoiesis. Pp. 111.
25. Geng Y., Weinberg R. Transforming growth factor-β effects on expression of G1 cyclins and cyclin-dependent protein kinases. Proc Natl Acad Sci U S A. 90:1993;10315.
26. Jacobsen F.W., Stokke T., Jacobsen S.E.W. Transforming growth factor-beta potently inhibits the ability-promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells. Blood. 86:1995;2957.
27. Komatsu N., Nakauchi H., Miwa A., Ishihara T., Eguchi M., Moroi M., Okada M., Sato Y., Wada H., Yamata Y., Suda T., Miura Y. Establishment and characterization of a human leukemic cell line with megakaryocytic features. dependency on granulocyte-macrophage colony stimulating factor, interleukin 3, or erythropoietin for growth and survival Cancer Res. 51:1991;341.
28. Hermine O., Mayeux P., Titeux M., Mitjavila M.T., Casadevall N., Guichard J., Komatsu N., Suda T., Miura Y., Vainchenker W., Breton-Gorius J. Granulocyte-macrophage colony-stimulating factor and erythropoietin act competitively to induce two different programs of differentiation in the human pluripotent cell line UT-7. Blood. 80:1992;3060.
29. Hermine O., Dubart A., Porteux F., Mayeux P., Titeux M., Dumenil D., Vainchencker W. Inhibition of the erythropoietin-induced erythroid differentiation by GM-CSF in the human UT-7 cell line is not due to a negative regulation of the erythropoietin receptor. Blood. 87:1996;1746.
30. Papayannopoulou T., Price M., Blue C. Kit ligand in synergy with interleukin-3 amplifies the erythropoietin-independent, globin-synthesizing progeny of normal human burst-forming units-erythroid in suspension cultures. physiological implications Blood. 81:1993;299.
31. Hermine O., Dussanter-Fourt I., Mayeux P., Auffray I., Mitjavila M., Vainchenker W. Mechanisms of growth factor hypersensitivity induced by stem cell factor in a pluripotent factor dependent cell line. Blood. 82:1993;213a.
32. Mayeux P., Casadevall N., Lacombe C., Muller O., Tambourin P. Solubilization and hydrodynamic characteristics of the erythropoietin receptor. Evidence for a multimeric complex. Eur J Biochem. 194:1990;271.
33. Ogawa M., Parmely R., Bank H., Spicer J. Human marrow erythropoiesis in culture. I. Characterization of methylcellulose colony essay. Blood. 48:1976;407.
34. Pic P., Ducrocq R., Girot R. Séparation des hémoglobines F, Fac, S, C, A1c et dosage de l'hémoglobine F par chromatographie liquide haute performance. Ann Biol Clin. 52:1994;129.
35. Dusanter-Fourt I., Casadevall N., Lacombe C., Muller O., Billat C., Fischer S., Mayeux P. Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells. J Biol Chem. 267:1992;10670.
36. Verdier F., Chretien S., Billat C., Gisselbrecht S., Lacombe C., Mayeux P. Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation. J Biol Chem. 272:1997;26173.
37. Hermine O., Beru N., Pech N., Goldwasser E. An autocrine role of erythropoietin in mouse hematopoietic cell differentiation. Blood. 78:1991;2253.
38. Carroll M., Zhu Y., D'Andrea A. Erythropoietin-induced cellular differentiation requires prolongation of the G1 phase of the cell cycle. Proc Natl Acad Sci U S A. 92:1995;26869.
39. Orkin S.H. Transcription factors and hematopoietic development. J Biol Chem. 270:1995;4955.
40. Zipori D. Regulation of hemopoiesis by cytokines that restrict options for growth and differentiation. Cancer Cells. 2:1990;205.
41. Geissmann F., Prost C., Monnet J.-P., Dy M., Brousse N., Hermine O. Transforming growth factor β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic langerhans cells. J Exp Med. 187:1998;961.
42. Moses H., Serra R. Regulation of differentiation by TGF-β Curr Opin Genet Develop. 6:1996;581.
43. Oshima M., Oshima H., Taketo M. TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol. 179:1996;297.
44. Krystal G., Lam V., Dragowska W., Takahashi C., Appel J., Gontier A., Jenkins A., Lam H., Quon L., Lansdorp P. Transforming growth factor beta-1 is an inducer of erythroid differentiation. J Exp Med. 180:1994;851.
45. Wu H., Liu X., Jaenisch R., Lodish H.F. Generation of committed eythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 83:1995;59.
46. Wu H., Klingmüller U., Besmer P., Lodish H.F. Interaction of the erythropoietin and stem-cell factor receptors. Nature. 377:1995;242.
47. Koury M.J., Bondurant M.C. A survival model of erythropoietin action. Science. 248:1990;378.
48. Baron M. Transcriptional control of globin gene switching during vertebrate development. Biochim Biophys Acta. 1351:1997;51.
49. Jackson H., Williams N., Westcott K.R., Green R. Differential effects of transforming growth factor-beta 1 on distinct developmental stages of murine megakaryocytopoiesis. J Cell Physiol. 161:1994;312.
50. Hatzfeld J., Li M.-L., Brown E., Sookdeo H., Levesque J.-P., O'Toole T., Gurney C., Clark S., Hatzfeld A. Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor β1 or Rb oligonucleotides. J Exp Med. 174:1991;925.
51. Saltis J. TGF-beta. receptors and cell cycle arrest Mol Cell Endocrinol. 116:1996;227.
52. Hooper W., Pruckler J., Jackson D., Evatt B. Transforming growth factor-β induces hemoglobin synthesis in a human erythroleukemia cell line. Biochem Biophys Res Comm. 165:1989;145.
53. Chen L., Dean A., Jenkinson T., Mendelsohn J. Effect of transforming growth factor-β1 on proliferation and induction of hemoglobin accumulation in K-562 cells. Blood. 74:1989;2368.
54. Ehinger M., Bergh G., Johnsson E., Gullberg U., Olsson I. The tumor suppressor gene p53 can mediate transforming the growth factor beta 1-induced differentiation of leukemic cells independently of activation of the retinoblastoma protein. Cell Growth Differ. 8:1997;1127.
55. Bergh G., Ehinger M., Olofsson T., Baldetorp B., Johnsson E., Brycke H., Lindgren G., Olsson I., Gullberg U. Altered expression of the retinoblastoma tumor-suppressor gene in leukemic cell lines inhibits induction of differentiation but not G1-accumulation. Blood. 89:1997;2938.
56. Russel E.S. Hereditary anemia of the mouse. A review for geneticists Adv Genet. 20:1979;357.