Chemical amplification (CHAMP) by a continuous, self-replicating oligonucleotide-based system [10]

Journal of the American Chemical Society

Volumn 121, Issue 29, 1999, Pages 6954-6955

  Albagli, David ^a   Van Atta, Reuel ^a   Cheng, Peter ^a   Huan, Bingfang ^a   Wood, Michael L ^a  

^a NAXCOR   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; OLIGONUCLEOTIDE;

DNA PROBE; GENE AMPLIFICATION; LETTER; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PHOTOCHEMISTRY; REACTION ANALYSIS;

EID: 0033612750     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja990434y     Document Type: Letter

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28. In an equilibrated solution of two probes and a target, an 80% yield of cross-linked probe-probe product is obtained in ∼4 min irradiation. The amplification experiments however use a container with a more restricted light acceptance, resulting in cross-linking rates half as fast. Data for the extent of reaction vs irradiation time is available in the Supporting Information.
29. Whereas a hybridization period is not strictly necessary, having one improves the overall amplification efficiency for a fixed total irradiation period (data not shown).
30. 10 For all other details see the Supporting Information.