Cross-linking hybridization assay for direct detection of factor V Leiden mutation

Clinical Chemistry

Volumn 43, Issue 9, 1997, Pages 1703-1708

  Zehnder, James ^a,b   Van Atta, Reuel ^a,b   Jones, Carol ^a,b   Sussman, Howard ^a,b   Wood, Michael ^a,b  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^b NAXCOR   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5;

BLOOD CLOTTING FACTOR 5 DEFICIENCY; CONFERENCE PAPER; CONTROLLED STUDY; CROSS LINKING; DNA HYBRIDIZATION; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; THROMBOPHILIA;

EID: 0030882594     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/43.9.1703     Document Type: Conference Paper

References (12)

1. Dahlback B. Physiological anticoagulation. Resistance to activated protein C and venous thromboembolism. J Clin Invest 1994;94:923-7.
2. Ridker PM, Miletich JP, Stampfer MJ, Goldhaber SZ, Lindpaintner K, Hennekens CH. Factor V Leiden and risks of recurrent idiopathic venous thromboembolism. Circulation 1995;92:2800-2.
3. Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995;332: 912-7.
4. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995;85:1504-8.
5. Svensson PJ, Dahlback B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994;330:517-22.
6. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dinen RJ, de Ronde H, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-7.
7. Kalafatis M, Bertina RM, Rand MD, Mann KG.' Characterization of the molecular defect in factor VR506Q. J Biol Chem 1995;270: 4053-7.
8. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995;346:1133-4.
9. Dahlback B. Resistance to activated protein C, the Arg506 to Gin mutation in the factor V gene, and venous thrombosis. Functional tests and DNA-based assays, pros and cons. Thromb Haemost 1995:73:739-42.
10. Zehnder JL, Benson RC. Sensitivity and specificity of the APC resistance assay in detection of individuals with factor V Leiden. Am J Clin Pathol 1996:106:107-11.
11. Maniatis T, Fritsch E, Sambrook J. Molecular cloning, a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Press, 1982.
12. Wood M, Albagli D, Cheng P, Huan B, Van Atta R. Nucleic acid crosslinking probes for DNA/RNA diagnostics [Abstract]. Clin Chem 1996:42:5196.