In vivo T cell depletion in miniature swine using the swine CD3 immunotoxin, pCD3-CRM9

Transplantation

Volumn 68, Issue 6, 1999, Pages 855-860

  Huang, Christene A ^a   Yamada, Kazuhiko ^a   Murphy, Michael C ^a   Shimizu, Akira ^a   Colvin, Robert B ^a   Neville Jr , David M ^b   Sachs, David H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; DIPHTHERIA TOXIN; IMMUNOTOXIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHIMERA; CONTROLLED STUDY; FLOW CYTOMETRY; HEMATOPOIETIC CELL; HISTOCOMPATIBILITY; HISTOLOGY; LYMPHOCYTE COUNT; NONHUMAN; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD3; BACTERIAL PROTEINS; BLOOD; DIPHTHERIA TOXIN; IMMUNOTOXINS; LYMPH NODES; LYMPHOCYTE DEPLETION; PERIPHERAL NERVOUS SYSTEM DISEASES; SWINE; SWINE, MINIATURE; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0033610247     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199909270-00019     Document Type: Article

References (32)

1. Sykes M, Sachs DH. Mixed allogeneic chimerism as an approach to transplantation tolerance [published erratum appears in Immunol Today 1988 May;9(5):131]. Immunol Today 1988; 9: 23.
2. Jankowski RA, Ildstad ST. Chimerism and tolerance: from freemartin cattle and neonatal mice to humans. Hum Immunol 1997; 52: 155.
3. Sykes M. Hematopoietic cell transplantation for the induction of allo- and xenotolerance. Clin Transplant 1996; 10: 357.
4. De Waal LP, Van Twuyver E. Blood transfusion and allograft survival: is mixed chimerism the solution for tolerance induction in clinical transplantation? Crit Rev Immunol 1991; 10: 417.
5. Sharabi Y, Abraham VS, Sykes M, Sachs DH. Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance. Bone Marrow Transplant 1992; 9: 191.
6. Sykes M, Szot GL, Swenson KA, Pearson DA. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nat. Med 1997; 3: 783.
7. Kawai T, Wong J, MacLean J, Cosimi AB, Wee SL. Characterization of a monoclonal antibody (6G12) recognizing the cynomolgus monkey CD3 antigen. Transplant. Proc 1994; 26(4): 1845.
8. Suzuki T, Sundt TM, Mixon A, Sachs DH. In vivo treatment with anti-porcine T-cell antibodies. Transplantation 1990; 50: 76.
9. Neville DMJ, Scharff J, Hu HZ, et al. A new reagent for the induction of T-cell depletion, anti-CD3-CRM9. J Immunother Emphasis Tumor Immunol 1996; 19: 85.
10. Knechtle SJ, Vargo D, Fechner J, et al. FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts. Transplantation 1997; 63: 1.
11. Contreras JL, Wang PX, Eckhoff DE, et al. Peritransplant tolerance induction with anti-CD3-immunotoxin: a matter of proinflammatory cytokine control. Transplantation 1998; 65: 1159.
12. Sachs DH, Leight G, Cone J, Schwartz S, Stuart L, Rosenberg S. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation 1976; 22: 559.
13. Ierino FL, Yamada K, Lorf T, Arn JS, Sachs DH. Mechanism of tolerance to class I-mismatched allografts in miniature swine: Regulation of interleukin-2 receptor α-chain expression on CD8 peripheral blood lymphocytes of tolerant animals. Transplantation 1998; 66: 454.
14. Huang CA, Lorf T, Arn JS, Koo GC, Blake T, Sachs DH. Characterization of a monoclonal anti-porcine CD3 antibody. Xenotransplant. 1999; (in press).
15. Hu VW, Holmes RK. Single mutation in the A domain of diphtheria toxin results in a protein with altered membrane insertion behavior. Biochim Biophys Acta 1987; 902: 24.
16. Neville DMJ, Srinivasachar K, Stone R, Scharff J. Enhancement of immunotoxin efficacy by acid-cleavable cross-linking agents utilizing diphtheria toxin and toxin mutants. J Biol Chem 1989; 264: 14653.
17. Welkos SL, Holmes RK. Regulation of toxinogenesis in Coryne-bacterium diphtheriae. I. Mutations in bacteriophage beta that alter the effects of iron on toxin production. J Virol 1981; 37: 936.
18. Carroll SF, Barbieri JT, Collier RJ. Diphtheria toxin: purification and properties. Methods Enzymol 1988; 165: 68.
19. Pescovitz MD, Lunney JK, Sachs DH. Preparation and characterization of monoclonal antibodies reactive with porcine PBL. J Immunol 1984; 133: 368.
20. Hammerberg C, Schurig GG. Characterization of monoclonal antibodies directed against swine leukocytes. Vet Immunol Immunopathol 1986; 11: 107.
21. Saalmuller A, Denham S, Haverson K, et al. The Second International Swine CD Workshop. Vet Immunol Immunopathol 1996; 54: 155.
22. Pescovitz MD, Book BK, Aasted B, et al. Summary of workshop findings for antibodies reacting with porcine T-cells and activation antigens: results from the Second International Swine CD Workshop. Vet Immunol Immunopathol 1998; 60: 251.
23. Tuazon TV, Schneeberger EE, Bhan AK, et al. Mononuclear cells in acute allograft glomerulopathy. Am J Pathol 1987; 129: 119.
24. Sachs DH, Mayer N, Tanemura M. Hybridoma antibodies directed toward murine H-2 and Ia antigens. In: Hammerling GJ, Hammerling U, Kearney JF, editors. Monoclonal antibodies and T cell hybridomas. Amsterdam, Elsevier/North-Holland Biomedic, 1981: 95.
25. Yang H, Parkhouse RM. Phenotypic classification of porcine lymphocyte subpopulations in blood and lymphoid tissues. Immunology 1996; 89: 76.
26. Ildstad ST, Wren SM, Bluestone JA, Barbieri SA, Sachs DH. Characterization of mixed allogeneic chimeras: immunocompetence, in vitro reactivity, and genetic specificity of tolerance. J Exp Med 1985; 162: 231.
27. Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med 1989; 169: 493.
28. Sharabi Y, Sachs DH. Engraftment of allogeneic bone marrow following administration of anti-T cell monoclonal antibodies and low-dose irradiation. Transplant Proc 1989; 21: 233.
29. Sharabi Y, Sachs DH, Sykes M. T cell subsets resisting induction of mixed chimerism across various histocompatibility barriers. Proceedings of the 8th International Congress Immunol 1992; 801.
30. Vaughan TJ, Pascall JC, Brown KD. Tissue distribution of mRNA for heparin-binding epidermal growth factor. Biochem J 1992; 287: 681.
31. Naglich JG, Metherall JE, Russell DW, Eidels L. Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell 1992; 69: 1051.
32. Knechtle SJ, Fechner JH, Jr, Dong YC, et al. Primate renal transplants using immunotoxin. Surgery 1998; 124: 438.