Mechanism of tolerance to class I-mismatched renal allografts in miniature swine: Regulation of interleukin-2 receptor α-chain expression on CD8 peripheral blood lymphocytes of tolerant animals

Transplantation

Volumn 66, Issue 4, 1998, Pages 454-460

  Ierino, Francesco L ^a   Yamada, Kazuhiko ^a   Lorf, Thomas ^a,b   Arn, John S ^a   Sacks, David H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD8 ANTIGEN; CYCLOSPORIN A; INTERLEUKIN 2 RECEPTOR; MINOR HISTOCOMPATIBILITY ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GRAFT REJECTION; IMMUNOLOGICAL TOLERANCE; KIDNEY ALLOGRAFT; NONHUMAN; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; SWINE; THYMUS;

ANIMALS; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CD8-POSITIVE T-LYMPHOCYTES; KIDNEY TRANSPLANTATION; RECEPTORS, INTERLEUKIN-2; SWINE; SWINE, MINIATURE; UP-REGULATION;

EID: 0032572794     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199808270-00007     Document Type: Article

References (39)

1. Rosengard Br, Ojikutu CA, Guzzetta PC, et al. Induction of specific tolerance to class I-disparate renal allografts in miniature swine with cyclosporine. Transplantation 1992; 54: 490.
2. Gianello PR, Blancho G, Fishbein JF, et al. Mechanism of cyclosporin-induced tolerance to primarily vascularized allografts in miniature swine: effect of administration of exogenous IL-2. J Immunol 1994; 153: 4788.
3. Gianello PR, Yamada K, Fishbein JM, et al. Long-term acceptance of primarily vascularized renal allografts in miniature swine: systemic tolerance versus graft adaptation. Transplantation 1996; 61: 503.
4. Blancho G, Gianello P, Germana S, Baetscher M, Sachs DH, LeGuern C. Molecular identification of porcine interleukin-10: regulation of expression in a kidney allograft model. Proc Natl Acad Sci USA 1995; 92: 2800.
5. Blancho G, Gianello PR, Lorf T, et al. Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine. Transplantation 1997; 63: 26.
6. Yamada K, Gianello PR, Ierino FL, et al. Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts. J Exp Med 1997; 186: 497.
7. Sachs DH. MHC homozygous miniature swine. In: Swindle MM, Moody DC, Phillips LD, eds. Swine as models in biomedical research. Ames, Iowa: Iowa State University Press, 1992: 3.
8. Kirkman RL, Colvin MW, Flye GS, et al. Transplantation in miniature swine. VI. Factors influencing survival of renal allografts. Transplantation 1979; 28: 18.
9. Kortz EO, Sakamoto K, Suzuki T, et al. Mechanism of tolerance following class I-disparate renal allografts in miniature swine: cellular responses of tolerant animals. Transplantation 1990; 49: 1142.
10. Bailey M, Stevens K, Bland PW, Stokes CR. A monoclonal antibody recognising an epitope associated with pig interleukin-2 receptors. J Immunol Methods 1992; 153: 85.
11. Pescovitz MD, Lunney JK, Sachs DH. Preparation and characterization of monoclonal antibodies reactive with porcine PBL. J Immunol 1984; 133: 368.
12. Lunney JK, Pescovitz MD. Phenotypic and functional characterization of pig lymphocyte populations. Vet Immunol Immunopathol 1987; 17: 135.
13. Ivanoska D, Sun DC, Lunney JK. Production of monoclonal antibodies reactive with polymorphic and monomorphic determinants of SLA class I gene products. Immunogenetics 1991; 33: 220.
14. Watanabe M, Suzuki T, Taniguchi M, Shinohara N. Monoclonal anti-Ia murine alloantibodies crossreactive with the Ia-homologues of other mammalian species including humans. Transplantation 1983; 36: 712.
15. Sachs DH, Mayer N, Ozato K. Hybridoma antibodies directed toward murine H-2 and Ia antigens. In: Hammerling GJ, Hammerling U, Kearney JF, eds. Monoclonal antibodies and T cell hybridomas. Elsevier: North-Holland Biomedic, 1981: 95.
16. Borel JF. Pharmacology of cyclosporine (Sandimmune). IV. Pharmacological properties in vivo [Published erratum appears in Pharmacol Rev 1990 Jun; 42(2): 125]. Pharmacol Rev 1990; 41: 259.
17. Smith KA. Interleukin-2: inception, impact and implications. Science 1988; 240: 1169.
18. Waldmann TA. The interleukin-2 receptor. J Biol Chem 1991; 266: 2681.
19. Alard P, Lantz O, Perrot JY, Chavanel G, Senik A, Charpentier B. A possible role for specific "anergy" in immunologic hypore-activity to donor stimulation in human kidney allograft recipients. Transplantation 1993; 55: 277.
20. Dallman MJ, Shiho O, Page TH, Wood KJ, Morris PJ. Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J Exp Med 1991; 173: 79.
21. Kirkman RL, Barrett LV, Gaulton GN, et al. The effect of anti-interleukin-2 receptor monoclonal antibody on allograft rejection. Transplantation 1985; 40: 719.
22. Reed MH, Shapiro ME, Strom TB, et al. Prolongation of primate renal allograft survival by anti-Tac, an anti-human IL-2 receptor monoclonal antibody. Transplantation 1989; 47: 55.
23. Soulillou JP, Peyronnet P, Le Mauff B, et al. Prevention of rejection of kidney transplants by monoclonal antibody directed against interleukin 2. Lancet 1987; 1: 1339.
24. Soulillou JP, Le Mauff B, Cantarovich D, Hourmant M, Vie H, Jacques Y. Use of a monoclonal antibody directed against interleukin 2 receptor in recipients of kidney allografts. Transplant Proc 1988; 20 (suppl 6): 84.
25. Schwartz R. A cell culture model for T lymphocyte clonal anergy. Science 1990; 248: 1349.
26. Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol 1993; 11: 191.
27. Schonrich G, Kalinke U, Momburg F, et al. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 1991; 65: 293.
28. Zhang L, Fung-Leung W, Miller RG. Down-regulation of CD8 on mature antigen-reactive T cells as a mechanism of peripheral tolerance. J Immunol 1995; 155: 3464.
29. Giangrande I, Yamada K, Germana S, Sachs D, LeGuern C. Tolerant cells infiltrating class I mismatched swine kidney allografts lack the CD4 single positive subset and down regulate TcR gene expression. Transplant Proc 1997; 29: 1164.
30. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993; 151: 1224.
31. Willems F, Marchant A, Delville JP, et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994; 24: 1007.
32. Chang CH, Furue M, Tamaki K. B7-1 expression of Langerhans cells is up-regulated by proinflammatory cytokines, and is down-regulated by interferon-gamma or by interleukin-10. Eur J Immunol 1995; 25: 394.
33. + T cells. J Exp Med 1996; 184: 19.
34. Guerder S, Carding SR, Flavell RA. B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors. J Immunol 1995; 155: 5167.
35. + T cells. J Immunol 1997; 158: 637.
36. + T cell: receptor dependent cytolysis in the absence of interleukin-2 production. Science 1991; 251: 1228.
37. + T cells. J Immunol 1997; 158: 1551.
38. Gianello PR, Fishbein JF, Rosengard BR, et al. Tolerance to class I disparate renal allografts in miniature swine: maintenance of tolerance despite induction of specific antidonor CTL responses. Transplantation 1995; 59: 772
39. + suppressor cell and its mechanism of action. J Exp Med 1990; 171: 141.