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0344744151
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note
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3 The initial polydispersity index of 13 was 1.2, and all spectra were recorded at that purity level. Preparative TLC on a portion was used to sharpen the index to 1.06.
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23
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0345606369
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note
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The overall yields of the final 17-mer 13 was determined by comparing the loading of the monomer 1 on the polymer support (compound 5) and the yield of the final oligomer when liberated from the polymer support: 5 (10.0 g, 4.8 mmol of loading of 1) → 6 (10.5 g) → 7 (10.3 g) → 8 (13.9 g) of which only a 7.2% mass portion (1.00 g) was taken on in the polymer-supported form → 9 (1.03 g) → 10 (0.98 g) → 12 (1.30 g) → 13 (0.31 g, 0.069 mmol). Starting from 4.8 mmol of 1 in 5 and using only 7.2% mass of the material during the conversion of 8 → 9, gives a theoretical yield of 0.35 mmol and an actual yield of 0.069 mmol (20%) for 13.
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25
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0013565682
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26
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37049117336
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Topsom, R.D.6
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