An androgen receptor mutation in the direct vicinity of the proposed C- terminal α-helix of the ligand binding domain containing the AF-2 transcriptional activating function core is associated with complete androgen insensitivity

Molecular and Cellular Endocrinology

Volumn 148, Issue 1-2, 1999, Pages 47-53

  Peters, I ^a   Weidemann, W ^a   Romalo, G ^b   Knorr, D ^c   Schweikert, H U ^b   Spindler, K D ^d  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

Androgen insensitivity; Androgen receptor mutation; AP 2 transcriptional activating function; Co activator; Nuclear receptor

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CELL NUCLEUS RECEPTOR; TRANSCRIPTION FACTOR AP 2;

ADULT; ALPHA HELIX; AMINO ACID SUBSTITUTION; ANDROGEN INSENSITIVITY SYNDROME; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CASE REPORT; CODON; EXON; GENE MUTATION; HUMAN; HUMAN CELL; KARYOTYPE 46,XY; LIGAND BINDING; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; SEX DIFFERENTIATION; SINGLE STRAND CONFORMATION POLYMORPHISM; SKIN FIBROBLAST; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; VIRILIZATION;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANDROGEN-INSENSITIVITY SYNDROME; ANDROGENS; BASE SEQUENCE; BINDING SITES; DIHYDROTESTOSTERONE; HUMANS; KARYOTYPING; KINETICS; MALE; MOLECULAR SEQUENCE DATA; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ANDROGEN; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TESTIS; TRANS-ACTIVATION (GENETICS);

EID: 0033602265     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(98)00237-8     Document Type: Article

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