Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4- ones and benzthiazin-4-ones as inhibitors of complement C1r protease

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 6, 1999, Pages 815-820

  Plummer, Janet S ^a   Cai, Cuiman ^a   Hays, Sheryl J ^a   Gilmore, John L ^a   Emmerling, Mark R ^a   Michael, Walter ^a   Narasimhan, Lakshmi S ^a   Watson, M Desiree ^a   Wang, Kevin ^a   Nath, Rathna ^a   Evans, Lori M ^a   Jaen, Juan C ^b  

^a PFIZER INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 SULFONYL 4H 3,1 BENZOXAZINONE DERIVATIVE; BENZENESULFONAMIDE DERIVATIVE; COMPLEMENT COMPONENT C1; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; HEMOLYSIS; NONHUMAN; STRUCTURE ANALYSIS;

ANIMALS; COMPLEMENT C1 INACTIVATOR PROTEINS; COMPLEMENT C1R; ERYTHROCYTES; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; SHEEP; SULFONAMIDES;

ANIMALIA;

EID: 0033594213     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00095-5     Document Type: Article

References (14)

1. (a) Asghar, S. S. Pharmacolg.l Rev. 1984, 36, 223.
2. (b) Tomlinson, S. Curr. Opin. Immunol. 1993, 5, 83.
3. (a)Rogers, J.; Cooper, N. R.; Webster, S.; Schultz, J. McGeer, P. L.; Lieberburg, I. Proc. Natl. Acad. Sci. 1992, 89, 10016.
4. (b) Haga, S.; Ikeda, K.; Sato, M.; Ishii, T. Brain Res. 1993, 601, 88.
5. Jiang, H.; Burdick, D.; Glabe, C. G.; Cotman, C. W.; Tenner, A. J. Immunol. 1994, 152, 5050.
6. Watson, M. D.; Roher, A. E.; Kim, K. S.; Spiegel, K.; Emmerling, M. R. Amyloid 1997, 4, 147.
7. Emmerling, M. R.; Spiegel, K.; Watson, M. D. Immunopharmacology 1997, 38, 101.
8. Aoyama, T.; Ino, Y.; Ozeki, M.; Oda, M.; Sato, T.; Koshiyama, Y.; Suzuki, S.; Fujita, M. Jpn. J. Pharmacol. 1984, 35, 203.
9. Gilmore, J. L.; Hays, S.J.; Caprathe, B.W.; Lee, C.; Emmerling, M. R.; Michael, W.; Jean, J. C. Bioorg. Med. Chem. Lett. 1996, 6, 679.
10. Hays, S. J.; Caprathe, B. W.; Gilmore, J. L.; Amin, N.; Emmerling, M. R.; Michael, W.; Nadimpalli, R.; Nath, R.; Raser, K. J.; Stafford, D.; Watson, D.; Wang, K.; Jaen, J. C. J. Med. Chem. 1998, 41, 1060.
11. Papadopoulos, E. P.: Torres, C. D. J. Heterocycle Chem 1982, 19, 269.
12. (a) Topliss, J. G. J. Med. Chem. 1977, 20, 463.
13. (b) Topliss, J. G. J. Med. Chem. 1972, 15, 1006.
14. Neumann, U.; Guetschow, M. Bioorg. Chem. 1995, 23, 72.