A membrane-fixed, truncated isoform of the human growth hormone receptor

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 11, 1997, Pages 3813-3817

  Amit, Tamar ^a   Bergman, Tal ^a   Dastot, Florence ^b   Youdim, Moussa B H ^a   Amselem, Serge ^b   Hochberg, Ze'ev ^a,c  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b HENRI MONDOR HOSPITAL   (France)

^c RAMBAM MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE RECEPTOR;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL SURFACE; CHINESE HAMSTER; GENE DELETION; GROWTH HORMONE RELEASE; HORMONAL REGULATION; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SYNTHESIS; RECEPTOR DOWN REGULATION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0030698140     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.11.3813     Document Type: Article

References (26)

1. Leung DW, Spencer SA, Cachianes G, et al. 1987 Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature. 330:537-543.
2. Cunningham BC, Ultsch M, De Vos AM, Mulkerrin MG, Clauser KR, Wells JA, 1991 Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science. 254:821-825.
3. Roupas P, Herington AC. 1989 Cellular mechanisms in the processing of growth hormone and its receptor. Mol Cell Endocrinol. 61:1-12.
4. Bick T, Amit T, Manzur M, Bar-Am O, Youdim MBH, Hochberg Z. 1996 Regulation of cellular rabbit growth hormone (GH) receptor and GH-binding protein generation in vitro. Endocrinology. 147:3977-3985.
5. Herington AC, Ymer S, Stevenson J. 1986 Identification and characterization of specific binding proteins for growth hormone in normal human sera. J Clin Invest. 77:1817-1823.
6. Baumann G, Stolar MW, Amburn K, Barasano CP, Devries BC. 1986 A specific growth hormone binding protein in human plasma: initial characterization. J Clin Endocrinol Metab. 62:134-141.
7. Urbanek M, Russel JE, Cooke NE, Liebhaber SA. 1993 Functional characterization of the alternatively spliced, placental human growth hormone receptor. J Biol Chem. 268:19025-12032.
8. Sobrier M-L, Duquesnoy P, Duriez B, Amselem S, Goossens M. 1993 Expression and binding properties of 2 isoforms of the human growth hormone receptor. FEBS Lett. 319:16-20.
9. Esposito N, Paterlini P, Kelly PA, Postel-Vinay M-C, Finidori J. 1994 Expression of two isoforms of the human growth hormone receptor in normal liver and hepatocarcinoma. Mol Cell Endocrinol. 103:13-20.
10. Dastot F, Sobrier M-L, Duquesnoy P, Duriez B, Goossens M, Amselem S. 1996 Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein. Proc Natl Acad Sci USA. 93:10723-10728.
11. Ross RJM, Esposito N, Shen XY, et al. 1997 A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein. Mol Endocrinol. 11:265-273.
12. Ellis L, Clauser E, Morgan D, Edery M, Roth R, Rutter W. 1986 Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell. 45:721-732.
13. Duriez B, Sobrier M-L, Duquesnoy P, et al. 1993 A naturally occurring growth hormone receptor mutation: in vivo and in vitro evidence for the functional importance of the WS motif common to all members of the cytokine receptor superfamily. Mol Endocrinol. 7:806-814.
14. Munson PJ, Rodbard D. 1980 LIGAND: a versatile computerized approach for characterization of ligand binding systems. Anal Biochem. 107:220-239.
15. Roupas P, Herington AC. 1987 Receptor-mediated endocytosis and degradative processing of growth hormone by rat adipocytes in primary culture. Endocrinology. 120:2158-2165.
16. Moldrup A, Allevato G, Dyrberg T, Nielsen JH, Billestrup N. 1991 Growth hormone action in rat insulinoma cells expressing truncated growth hormone receptors. J Biol Chem. 266:17441-17445.
17. Allevato G, Billestrup N, Goujon L, et al. 1995 Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation. J Biol Chem. 270:17210-17214.
18. Colosi P, Wong K, Leong SR, Wood WI. 1993 Mutational analysis of the intracellular domain of the human growth hormone receptor. J Biol Chem. 268:12617-12623.
19. Strous G, Kerkhof P, Govers R, Ciechanover A, Schwartz A. 1996 The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J. 15:3806-3812.
20. Bick T, Youdim MBH, Hochberg Z. 1989 Adaptation of liver membrane somatogenic and lactogenic growth hormone (GH) binding to the spontaneous pulsation of GH secretion in the male rat. Endocrinology. 125:1711-1717.
21. Amit T, Bick T, Youdim MBH, Hochberg Z. 1996 In search of the cellular site of growth hormone (GH)-binding protein cleavage from the rabbit GH receptor. Endocrinology. 137:3986-3991.
22. Deutsch PJ, Rosen IM, Rubin CS. 1982 Identification and characterization of a latent pool of insulin receptors in 3T3-L1 adipocytes. J Biol Chem. 257:5350-5358.
23. King AC, Cuatrecasas P. 1981 Peptide hormone-induced receptor mobility, aggregation and internalization. N Engl J Med. 305:77-88.
24. Lim L, Spencer SA, McKay P, Waters MJ. 1990 Regulation of growth hormone (GH) bioactivity by a recombinant GH-binding protein. Endocrinology. 127:1287-1291.
25. Amit T, Barkey RJ, Youdim MBH, Hochberg Z. 1992 The effect ot human growth hormone (GH)-binding proteins in human serum on GH binding to rabbit liver membranes. Metabolism. 41:732-737.
26. Blumenfeld Z, Barkey RJ, Youdim MBH, Brandes JM, Amit T. 1992 Growth hormone binding protein regulation by estrogen, progesterone and gonadotropins in human: the effect of ovulation induction with menopausal gonadotropins, growth hormone and gestation. J Clin Endocrinol Metab. 75:1242-1249.