Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease

Neuroscience Letters

Volumn 267, Issue 1, 1999, Pages 65-68

  Kanai, Mitsuyasu ^a   Shizuka, Masami ^a   Urakami, Katsuya ^b   Matsubara, Etsuro ^a   Harigaya, Yasuo ^a   Okamoto, Koichi ^a   Shoji, Mikio ^a  

^a GUNMA UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

A ; Alzheimer's disease; Apolipoprotein E4; Cerebrospinal fluid; Tau

Indexed keywords

APOLIPOPROTEIN E4; BIOLOGICAL MARKER; TAU PROTEIN;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DEMENTIA; DETERIORATION; DISEASE COURSE; FEMALE; HUMAN; MALE; MENTAL HEALTH; PRIORITY JOURNAL; SENILE PLAQUE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; DEMENTIA; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; TAU PROTEINS;

EID: 0033591203     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00323-7     Document Type: Article

References (20)

1. Bales K.R., Verina T., Dodel R.C., Du Y., Altstiel L., Bender M., Hyslop P., Johnstone E.M., Little S.P., Cummins D.J., Piccardo P., Ghetti B., Paul S.M. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nat. Genet. 17:1997;263-264.
2. Castaño E.M., Prelli F., Wisniewski T., Golabek A., Kumar R.A., Soto C., Frangione B. Fibrillogenesis in Alzheimer's disease of amyloid β peptide and apolipoprotein E. Biochem. J. 306:1995;599-604.
3. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., Roses A.D., Haines J.L., Pericak-Vance M.A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923.
4. Craft S., Teri L., Edland S.D., Kukull W.A., Schellenberg G., McCormick W.C., Bowen J.D., Larson E.B. Accelerated decline in apolipoprotein E-ε4 homozygotes with Alzheimer's disease. Neurology. 51:1998;149-153.
5. Frisoni G.B., Govoni S., Geroldi C., Bianchetti A., Calabresi L., Franceschini G., Trabucchi M. Gene dose of the ε4 allele of apolipoprotein E and disease progression in sporadic late-onset Alzheimer's disease. Ann. Neurol. 37:1995;596-604.
6. Galasko D., Chang L., Motter R., Clark C.M., Kaye J., Knopman D., Thomas R., Kholodenko D., Schenk D., Lieberburg I., Miller B., Green R., Basherad R., Kertiles L., Boss A., Seubert P. High cerebrospinal fluid tau and low amyloid β42 levels in the clinical diagnosis of Alzheimer disease and relation to Apolipoprotein E genotype. Arch. Neurol. 55:1998;937-945.
7. Gomez-Isla T., West H.L., William Rebeck G., Harr S.D., Growdon J.H., Locascio J.J., Perls T.T., Lipsitz, L.A., Hyman B.T. Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease. Ann. Neurol. 39:1996;62-70.
8. Igeta Y., Kawarabayashi T., Sato M., Yamada N., Matsubara E., Ishiguro K., Kanai M., Tomidokoro Y., Osuga J., Okamoto K., Hirai S., Shoji M. Apolipoprotein E accumulates with the progression of Aβ deposition in transgenic mice. J. Neuropathol. Exp. Neurol. 56:1997;1228-1235.
9. Jonker C., Schmand B., Lindeboom J., Havekes L.M., Launer L.J. Association between apolipoprotein E ε4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia. Arch. Neurol. 55:1998;1065-1069.
10. Kanai M., Matsubara E., Isoe K., Urakami K., Nakashima K., Arai H., Sasaki H., Abe K., Iwatsubo T., Kosaka T., Watanabe M., Tomidokoro Y., Shizuka M., Mizushima K., Nakamura T., Igeta Y., Ikeda Y., Amari M., Kawarabayashi T., Ishiguro K., Harigaya Y., Wakabayashi K., Okamoto K., Hirai S., Shoji M. Longitudinal study of cerebrospinal fluid levels of tau, Aβ1-40, and Aβ1-42(43) in Alzheimer's disease: a study in Japan. Ann. Neurol. 44:1998;17-26.
11. Kraemer H.C., Tinklenberg J., Yesavage J.A. 'How far' vs'how fast' in Alzheimer's disease. Arch. Neurol. 51:1994;275-279.
12. Mayeux R., Stern Y., Ottman R., Tatemichi T.K., Tang M., Maestre G., Ngai C., Tycko B., Ginsberg H. The apolipoprotein ε4 allele in patients with Alzheimer's disease. Ann. Neurol. 34:1993;752-754.
13. McNamara M.J., Gomez-Isla T., Hyman B.T. Apolipoprotein E genotype and deposits of Aβ40 and Aβ42 in Alzheimer disease. Arch. Neurol. 55:1998;1001-1004.
14. Meyer M.R., Tschanz J.T., Norton M.C., Welsh-Bohmer K.A., Steffens D.C., Wyse B.W., Breitner J.C.S. APOE genotype predicts when - not whether - one is predisposed to develop Alzheimer disease. Nat. Genet. 19:1998;321-322.
15. Polvikoski T., Sulkava R., Haltia M., Kainulainen K., Vuorio A., Verkkoniemi A., Niinistö L., Halonen P., Kontula K. Apolipoprotein E, dementia, and cortical deposition of β-amyloid protein. N. Engl. J. Med. 333:1995;1242-1247.
16. Saunders A.M., Strittmatter W.J., Schmechel D., St. George-Hyslop P.H., Pericak-Vance M.A., Joo S.H., Rosi B.L., Gusella J.F., Crapper-MacLachlan D.R., Alberts M.J., Hulette C., Crain B., Goldgaber D., Roses A.D. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 43:1993;1467-1472.
17. Strittmatter W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G.S., Roses A.D. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA. 90:1993;1977-1981.
18. Strittmatter W.J., Weisgraber K.H., Goedert M., Saunders A.M., Huang D., Corder E.H., Dong L., Jakes R., Alberts M.J., Gilbert J.R., Han S., Hulette C., Einstein G., Schmechel D.E., Pericak-Vance M.A., Roses A.D. Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp. Neurol. 125:1994;163-171.
19. Tapiola T., Lehtovirta M., Ramberg J., Helisalmi S., Linnaranta K., Riekkinen P., Soininen H. CSF tau is related to apolipoprotein E genotype in early Alzheimer's disease. Neurology. 50:1998;169-174.
20. Wenham P.R., Price W.H., Blundell G. Apolipoprotein E genotyping by one-stage PCR. Lancet. 337:1991;1158-1159.