9-[(2'S,3'S)-3'-formyl-2',3'-dihydroxypropyl]adenine: A facile affinity-labeling probe of human S-adenosyl-L-homocysteine hydrolase

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 18, 1999, Pages 2737-2740

  Kitade, Yukio ^a   Nakanishi, Masayuki ^a   Yatome, Chizuko ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

9 (2,3 DIHYDROXYPROPYL)ADENINE; 9 (3' FORMYL 2',3' DIHYDROXYPROPYL)ADENINE; ADENOSYLHOMOCYSTEINASE; HYPOXANTHINE DERIVATIVE; NUCLEOSIDE; UNCLASSIFIED DRUG;

AFFINITY LABELING; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); DRUG SYNTHESIS; ENZYME INACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MOLECULAR PROBE; STRUCTURE ANALYSIS;

ADENINE; ADENOSYLHOMOCYSTEINASE; AFFINITY LABELS; HUMANS; HYDROLASES; RECOMBINANT PROTEINS;

EID: 0033588859     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00470-9     Document Type: Article

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21. m values of the human recombinant SAH hydrolase to adenosine were 3.4 μmol/min/mg and 1.6 μM, respectively.
22. 2 mean FDHPA (4) and SAH hydrolase, respectively.