Expression of inducible nitric oxide synthase immunoreactivity in rat brain following chronic hypoxia: Effect of aminoguanidine

Neuroscience Letters

Volumn 271, Issue 2, 1999, Pages 109-112

  Niwa, Kiyoshi ^a   Takizawa, Shunya ^a   Kawaguchi, Chikako ^a   Kamiya, Uguri ^a   Kuwahira, Ichiro ^a   Shinohara, Yukito ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aminoguanidine; Angiogenesis; Brain ischemia; Chronic normobaric hypoxia; Inducible nitric oxide synthase

Indexed keywords

AMINOGUANIDINE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN ISCHEMIA; CONTROLLED STUDY; HIPPOCAMPUS; HYPOXIA; IMMUNOREACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BRAIN; CHRONIC DISEASE; ENZYME INHIBITORS; GUANIDINES; HYPOXIA, BRAIN; MALE; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033588241     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00534-0     Document Type: Article

References (17)

1. Cervós-Navarro J., Sampaolo S., Hamdorf G. Brain changes in experimental chronic hypoxia. Exp. Pathol. 42:1991;205-212.
2. Diaz-Flores L., Gutiérrez R., Varela H. Angiogenesis: an update. Histol. Histopath. 9:1994;807-843.
3. Graham R.C., Karnovsky M.J. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J. Histochem. Cytochem. 14:1996;291-302.
4. Iadecola C., Zhang F., Xu X. Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am. J. Physiol. 268:1995;R286-R292.
5. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci. 20:1997;132-139.
6. Le Cras T.D., Xue C., Rengasamy A., Johns R.A. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am. J. Physiol. 270:1996;L164-L170.
7. Lyons M.K., Anderson R.E., Meyer F.B. Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia. Brain Res. 558:1991;315-320.
8. Osei S.Y., Ahima R.S., Fabry M.E., Nagel R.L., Bank N. Immunohistochemical localization of hepatic nitric oxide synthase in normal and transgenic sickle cell mice: the effect of hypoxia. Blood. 88:1996;3583-3588.
9. Patt S., Sampaolo S., Théallier-Jankó Á., Tschairkin I., Cervós-Navarro J. Cerebral angiogenesis triggered by severe chronic hypoxia displays regional differences. J. Cereb. Blood Flow Metab. 17:1997;801-806.
10. Palladini G., Conforti A., Medolago-Albani L. Ultrastructural hypoxic changes in Ammon's horn and Purkinje cells. Brain Res. 103:1976;45-56.
11. Sessa A., Perin A. Diamine oxidase in relation to diamine and polyamine metabolism. Agents Actions. 43:1994;69-77.
12. Stewart P.A., Isaacs H., LaManna J.C., Harik S.I. Ultrastructual concomitants of hypoxia-induced angiogenasis. Acta Neuropathol. 93:1997;579-584.
13. Takizawa S., Fukuyama N., Hirabayashi H., Nakazawa H., Shinohara Y. Dynamics of nitrotyrosine formation and decay in rat brain during focal ischemia-reperfusion. J. Cereb. Blood Flow Metab. 19:1999;667-672.
14. Xue C., Reynolds P.R., Johns R.A. Developmental expression of NOS isoforms in fetal rat lung: implications for transitional circulation and pulmonary angiogenesis. Am. J. Physiol. 270:1996;L88-L100.
15. Yamagishi S., Yonekura H., Yamamoto Y., Katsuno K., Sato F., Mita I., Ooka H., Satozawa N., Kawakami T., Nomura M., Yamamoto H. Advanced glycation end products-driven angiogenesis in vitro. Induction of the growth and tube formation of human microvascular endothelial cells through autocrine vascular endothelial growth factor. J. Biol. Chem. 272:1997;8723-8730.
16. Ziche M., Morbidelli L., Choudhuri R., Zhang H-T., Donnini S., Granger H.J., Bicknell R. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J. Clin. Invest. 99:1997;2625-2634.
17. Zimmerman G.A., Meistrell M., Bloom O., Cockroft K.M., Bianchi M., Risucci D., Broome J., Farmer P., Cerami A., Vlassara H., Tracey K.J. Neurotoxicity of advanced glycation endproducts during focal stroke, and neuroprotective effects of aminoguanidine. Proc. Natl. Acad. Sci. USA. 92:1995;3744-3748.