Immunohistochemical localization of hepatic nitric oxide synthase in normal and transgenic sickle cell mice: The effect of hypoxia

Blood

Volumn 88, Issue 9, 1996, Pages 3583-3588

  Osei, S Y ^a   Ahima, R S ^a   Fabry, M E ^a   Nagel, R L ^a   Bank, N ^a  

^a MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; LIVER ENZYME; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME POLYMORPHISM; HYPOXIA; ISCHEMIA; LIVER CELL DAMAGE; LIVER DYSFUNCTION; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SICKLE CELL ANEMIA; TRANSGENIC MOUSE;

EID: 0029858036     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.9.3583.bloodjournal8893583     Document Type: Article

References (34)

1. Bauer TW, Moore GW, Hutchins GM: The liver in sickle cell disease: A clinicopathologic study of 70 patients. Am J Med 69:833, 1980
2. Johnson CS, Omata M, Tong MJ, Simmons JF, Weiner J, Tatter D: Liver involvement in sickle cell disease. Medicine 64:349, 1985
3. Callaghan AO, O'Brien SG, Ninkovi M, Butcher GP, Foster CS, Walters JRF, Roberts IAG: Chronic intrahepatic cholestasis in sickle cell disease requiring exchange transfusion. Gut 37:144, 1995
4. Schubert TT: Hepatobiliary system in sickle cell disease. Gastroenterology 90:2013, 1986
5. Stephan JL, Merput-Gonon E, Richard O, Raynaud-Ravni C, Freylon F: Fulminant liver failure in a 12-year old girl with sickle cell anemia: Favourable outcome after exchange transfusions. Eur J Pediatr 154:469, 1995
6. Ballas SK, Lewis CN, Noone AM, Krasnow SH, Kamarulzaman E, Burka ER: Clinical, hematological and biochemical features of HbSC disease. Am J Hematol 13:37, 1982
7. Billiar TR, Curran RD, Harbrecht BG, Steuhr DJ, Demetris AJ, Simmons RL: Modulation of nitrogen oxide synthesis in vivo: NG-monomethyl-L-arginine inhibits endotoxin-induced nitrite/nitrate biosynthesis while promoting hepatic damage. J Leukoc Biol 48:565, 1990
8. Harbrecht BG, Billiar TR, Stadler J, Demetris AJ, Ochoa JB, Curran RD, Simmons RL: Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia. Crit Care Med 20:1568, 1992
9. Ma TT, Ischisopoulous H, Brass CA: Endotoxin stimulated nitric oxide production increased injury and reduces rat liver chemiluminescence during reperfusion. Gastroenterology 108:463, 1995
10. Billiar TR: The delicate balance of nitric oxide and superoxide in liver pathology. Gastroenterology 180:603, 1995
11. Bank N, Aynedjian HS, Qiu J, Osei SY, Ahima RS, Fabry ME, Nagel RL: Renal nitric oxide synthases in transgenic sickle cell mice. Kidney Int 50:184, 1996
12. Yu L, Gengaro PE, Niederberger M, Burke TJ, Schrier RW: Nitric oxide: A mediator in rat tubular hypoxia/reoxygenation injury. Proc Natl Acad Sci USA 91:1691, 1995
13. Lipton SA, Choi YB, Pan ZH, Lwi SZ, Chen HSV, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS: A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364:626, 1993
14. Wright CE, Rees DD, Moncada S: Protective and pathological roles of nitric oxide in endotoxic shock. Cardiovasc Res 26:48, 1992
15. Xie Q-W, Nathan C: The high-output nitric oxide pathway: Role and regulation. J Leukoc Biol 56:576, 1994
16. Nussler AK, DiSilvio M, Billiar T, Hoffman RA, Geller DA, Selby R, Madariaga J, Simmons RL: Stimulation of nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J Exp Med 176:261, 1992
17. Wood ER, Berger H Jr, Sherman PA, Lapentina EG: Hepatocytes and macrophages express an identical inducible nitric oxide synthase gene. Biochem Biophys Res Commun 191:767, 1993
18. Geller DA, Nussler AK, DiSilvio M, Lowenstein CJ, Shapiro RA, Wang SC, Simmons RL, Billiar TT: Cytokines, endotoxin and glucorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci USA 90:522, 1993
19. Buttery LDK, Evans TJ, Springall DR, Carpenter A, Cohen J, Polak JM: Immunochemical localization of inducible nitric oxide synthase in endotoxin-treated rats. Lab Invest 71:755, 1994
20. Fabry ME, Nagel RL, Pachnis A, Suzuka SM, Costantini F: High expression of human beta S- and alpha-globins in transgenic mice: Hemoglobin composition and hematological consequences. Proc Natl Acad Sci USA 89:12150, 1992
21. Rubin EM, Witkowska HE, Spangler E, Curtin P, Lubin BH, Mohandas N, Clift SM: Hypoxia-induced in vivo sickling of transgenic mouse red cells. J Clin Invest 87:639, 1991
22. Trudel M, De Paepe ME, Chretien N, Saadane N, Jacmain J, Sorette M, Hoang T, Beuzard Y: Sickle cell disease of transgenic SAD mice. Blood 84:3189, 1994
23. Fabry ME, Costantini FD, Pachnis A, Suzuka SM, Bank N, Aynedjian HS, Factor S, Nagel RL: High expression of human beta S- and alpha-globins in transgenic mice: Red cell abnormalities, organ damage, and the effect of hypoxia. Proc Natl Acad Sci USA 89:12155, 1992
24. McLean IW, Nakane PK: Periodate-lysine-paraformaldehyde fixative. A new fixative for immunoelectron microscopy. J Histochem Cytochem 22:1077, 1974
25. Fabry ME, Sengupta A, Suzuka SM, Costantini F, Rubin EM, Hofrichter J, Christoph GW, Manci EA, Culberson D, Factor SM, Nagel RL: A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity. Blood 86:2419, 1995
26. Pinsky DJ, Yan S-F, Lawson C, Naka Y, Chen JX, Connolly ES Jr, Stern DM: Hypoxia and modification of the endothelium: Implications for regulation of vascular homeostatic properties. Cell Biol 6:283, 1995
27. Shreeniwas R, Koga S, Pinsky S, Kaiser E, Brett J, Wolitzky B, Norton C, Plocinski J, Benjamin W, Burns D, Goldstein A, Stern D: Hypoxia-mediated induction of interleukin 1 alpha: An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface. J Clin Invest 90:2333, 1992
28. Rengasamy A, Johns RA: Characterization of endothelium-derived relaxing factor/nitric oxide synthase from bovine cerebellum and mechanism of modulation by high and low oxygen tensions. J Pharmacol Exp Ther 259:310, 1991
29. Lemaster JJ, Thurman RG: Centrilobular injury folowing hypoxia in isolated perfused rat liver. Science 213:661, 1981
30. Lemaster JJ, Stemkowski CJ, Sungchul J, Thurman RG: Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated, perfused rat liver. J Cell Biol 97:778, 1983
31. Brass CA, Crawford JM, Narciso J, Gollan JL: Hypoxic liver injury and the ameliorating effects of fructose: The glucose paradox revisited. Am J Physiol 263:G293, 1992
32. Suzuki H, Suematsu M, Ishii H, Kato S, Miki H, Mori M, Ishimura Y, Nishino T, Tsuchiga M: Prostaglandin El abrogates early reductive stress and zone-specific paradoxical oxidative injury in hypoperfused rat liver. J Clin Invest 93:155, 1994
33. Lautt WW: Method for measuring hepatic uptake of oxygen or other blood-borne substance in situ. J Appl Physiol 40:269, 1976
34. 2α in the perfused rat liver. Biochim Biophys Acta 1245:181, 1995