Sequence requirements for the nuclear localization of the murine cytomegalovirus M44 gene product pp50

Virology

Volumn 259, Issue 1, 1999, Pages 43-59

  Loh, Lambert C ^a   Keeler, Vicki D ^a   Shanley, John D ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; GENE PRODUCT; HYBRID PROTEIN; LYSINE; MONOCLONAL ANTIBODY; PHOSPHOPROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELL STRAIN COS1; CELLULAR DISTRIBUTION; CYTOMEGALOVIRUS; DELETION MUTANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 0033587331     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1999.9700     Document Type: Article

References (36)

1. Adam S.A ., Gerace L. Cytosolic proteins that specifically bind nuclear localization signal are receptors for nuclear import. Cell. 66:1991;837-847.
2. Adam S. A., Sterne-Marr R. E., Gerace L. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol. 111:1990;807-816.
3. Chang C. K., Balachandran N. Identification, characterization and sequence analysis of a cDNA encoding a phosphoprotein of human herpesvirus 6. J. Virol. 65:1991;2884-2894.
4. Digard P., Chow C. S., Pirrit L., Coen D. M. Functional analysis of the herpes simplex virus UL42 protein. J. Virol. 67:1993;1159-1168.
5. Dingwall C., Robbins J., Dilworth S. M., Roberts B., Richardson W. D. The nucleoplasmin nuclear location sequence is larger and more complex than that of SV40 large T antigen. J. Cell Biol. 107:1988;841-849.
6. Dingwall C., Laskey R. A. Protein import into the cell nucleus. Annu. Rev. Cell Biol. 2:1986;367-390.
7. Ertl P. F., Powell K. L. Physical and functional interaction of human cytomegalovirus DNA polymerase and its accessory protein (ICP36) expressed in insect cells. J. Virol. 66:1992;4126-4133.
8. Fuerst T. R., Niles E. G., Studier F. W., Moss B. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA. 83:1986;8122-8126.
9. Gao M., Knipe D. M. Distal protein sequences can affect the function of a nuclear localization signal. Mol. Cell. Biol. 12:1992;1330-1339.
10. Görlich D. Nuclear protein import. Curr. Opin. Cell Biol. 9:1997;412-419.
11. Görlich D., Mattaj I. W. Nucleocytoplasmic transport. Science. 271:1996;1513-1518.
12. Görlich D., Prehn S., Laskey R., Hartmann E. Isolation of a protein that is essential for the first step of nuclear protein import. Cell. 79:1994;767-778.
13. Harford C., Hamlin A., Riders E. Electron microscopic autoradiography of DNA synthesis in cell infected with caccinia virus. Exp. Cell Res. 42:1966;50-57.
14. Henikoff S. Unidirectional digestion with exonuclease III in DNA sequence analysis. Methods Enzymol. 155:1987;156-165.
15. Kalderon D., Richardson W. D., Markham A. F., Smith A. E. Sequence requirements for nuclear localization of SV40 large T antigen. Nature. 311:1984a;33-38.
16. Kalderon D., Roberts B. L., Richardson W. D., Smith A. E. A short amino acid sequence able to specify nuclear location. Cell. 39:1984b;499-509.
17. Loh L. C., Balachandran N., Britt W. J. Characterization of a membrane-associated phosphoprotein of murine cytomegalovirus (pp50) and its immunological cross-reactivity with a human cytomegalovirus protein. Virology. 183:1991;181-194.
18. Loh L. C., Britt W. J., Raggo C., Laferté S. Sequence analysis and expression of the murine cytomegalovirus phosphoprotein pp50, a homolog of the human cytomegalovirus UL44 gene product. Virology. 200:1994;413-427.
19. Pande H., Campo K., Shanley J. D., Creeger E. S., Artishevsky A., Gallez-Hawkins G., Zaia J. A. Characterization of a 52K protein of murine cytomegalovirus and its immunological cross-reactivity with the DNA-binding protein ICP36 of human cytomegalovirus. J. Gen. Virol. 72:1991;1421-1427.
20. Pari G. S., Anders D. G. Eleven loci encoding trans-acting factors are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA replication. J. Virol. 67:1993;6979-6988.
21. Pari G. S., Kacica M. A., Anders D. G. Open reading frames UL44, IRS1/TRS1, and UL36-38 are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA synthesis. J. Virol. 67:1993;2575-2582.
22. Picard D., Yamamoto K. R. Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J. 6:1987;3333-3340.
23. Plachter B., Nordin M., Wirgart B. Z., Mach M., Stein H., Grillner L., Jahn G. The DNA-binding protein P52 of human cytomegalovirus reacts with monoclonal antibody CCH2 and associates with the nuclear membrane at late times after infection. Virus Res. 24:1992;265-276.
24. Pollard V. W., Michael W. M., Nakielny S., Siomi M. C., Wang F., Dreyfuss G. A novel receptor-mediated nuclear protein import pathway. Cell. 86:1996;985-994.
25. Rawlinson W. D., Farrell H. E., Barrell B. G. Analysis of the complete DNA sequence of murine cytomegalovirus. J. Virol. 70:1996;8833-8849.
26. Rihs H., Jans D. A., Fan H., Peters R. The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking nuclear localization sequence of the SV40 T-antigen. EMBO J. 10:1991;633-639.
27. Ripalti A., Boccuni M. C., Campanini F., Landini M. P. Cytomegalovirus-mediated induction of antisense mRNA expression to UL44 inhibits virus replication in an astrocytoma cell line: Identification of an essential gene. J. Virol. 69:1995;2047-2057.
28. Robbins J., Dilworth S. M., Laskey R. A., Dingwall C. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequences. Cell. 64:1991;615-623.
29. Roberts B. L., Richardson W. S., Smith A. E. The effect of protein context on nuclear location signal function. Cell. 50:1987;465-475.
30. Sadowski I., Bell B., Broad P., Hollis M. GAL4 fusion vectors for expression in yeast or mammalian cells. Gene. 118:1992;137-141.
31. Shaulsky G., Goldfinger N., Ben-Zeev A., Rotter V. Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis. Mol. Cell. Biol. 10:1990;6565-6577.
32. Shaulsky G., Goldfinger N., Tosky M. S., Levine A. J., Rotter V. Nuclear localization is essential for the activity of p53 protein. Oncogene. 6:1991;2055-2065.
33. Siomi H., Dreyfuss G. A nuclear localization domain in the hnRNP A1 protein. J. Cell Biol. 129:1995;551-560.
34. Tillman U., Wagner J., Boerboom D., Westphal H., Tremblay M. L. Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase. Mol. Cell. Biol. 14:1994;3030-3040.
35. Weiland K. L., Oien N. L., Homa F., Wathen M. W. Functional analysis of human cytomegalovirus polymerase accessory protein. Virus Res. 34:1994;191-206.
36. Yao X. J., Subbramanian R. A., Rougeau N., Boisvert F., Bergeron D., Cohen E. A. Mutagenic analysis of human immunodeficiency virus type 1 Vpr: Role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation. J. Virol. 69:1995;7032-7044.