Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency

Journal of Medicinal Chemistry

Volumn 42, Issue 10, 1999, Pages 1767-1777

  Cushman, Mark ^a   Insaf, Shabana ^a   Paul, Gitendra ^a   Ruell, Jeffrey A ^a   De Clercq, Erik ^b   Schols, Dominique ^b   Pannecouque, Christophe ^b   Witvrouw, Myriam ^b   Schaeffer, Catherine A ^c   Turpin, Jim A ^c   Williamson, Karen ^c   Rice, William G ^c  

^a PURDUE UNIVERSITY   (United States)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD4 ANTIGEN; COSALANE; GLYCOPROTEIN GP 120; POLYANION; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN;

ARTICLE; BINDING AFFINITY; CELL MEMBRANE; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; HYPOTHESIS; PHARMACOPHORE; REVERSE TRANSCRIPTION; VIRUS ENVELOPE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-HIV AGENTS; ANTIGENS, CD4; AURINTRICARBOXYLIC ACID; BENZOIC ACIDS; CELL LINE; CHOLESTANES; HIV-1; HIV-2; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033587023     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980727m     Document Type: Article

References (29)

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