Studies directed toward a more potent cosalane pharmacophore: Synthesis of a substituted tetraphenylethylene which inhibits the cytopathic effect of HIV-1

Medicinal Chemistry Research

Volumn 6, Issue 6, 1996, Pages 372-376

  Keyes, Robert F ^a,b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0005950604     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

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12. We are using the term "pharmacophore" loosely here to mean "the region of the molecule which is responsible for the biological activity." A more rigorous definition of "pharmacophore" is "the critical three-dimensional arrangement of molecular fragments (or the distribution of electron density) that is recognized by the receptor and, in the case of agonists, that causes subsequent activation of the receptor on binding": Marshall, G. R. in Burger's Medicinal Chemistry and Drug Discovery. Volume 1: Principles and Practice, Wolff, M. E. Ed., John Wiley and Sons, Inc.: New York, 1995, pp 619-621.
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