Design and synthesis of N-alkylated saccharins as selective α-1a adrenergic receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 18, 1998, Pages 2467-2472

  Nerenberg, Jennie B ^a   Erb, Jill M ^a   Thompson, Wayne J ^a   Lee, Hee Yoon ^a   Guare, James P ^a   Munson, Peter M ^a   Bergman, Jeffrey M ^a   Huff, Joel R ^a   Broten, Theodore P ^a   Chang, Raymond S L ^a   Chen, Tsing B ^a   O'Malley, Stacey ^a   Schorn, Terry W ^a   Scott, Ann L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; FINASTERIDE; RECEPTOR SUBTYPE; SACCHARIN DERIVATIVE; TAMSULOSIN; TERAZOSIN;

ALKYLATION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; HYPOTENSION; LIGAND BINDING; NONHUMAN; PROSTATE HYPERTROPHY; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; URETHRA PRESSURE;

ADRENERGIC ALPHA-ANTAGONISTS; ALKYLATION; ANIMALS; AORTA; CELL LINE; CHO CELLS; CRICETINAE; DOGS; DRUG DESIGN; FINASTERIDE; HUMANS; MALE; MODELS, CHEMICAL; PRAZOSIN; PROSTATE; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; SACCHARIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 16744364284     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00446-6     Document Type: Article

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