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85069141010
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note
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3OD): δ 35.10, 66.54, 68.34, 68.40, 69.45, 70.01, 70.30, 74.42, 85.95.
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0025328344
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85069128985
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note
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6).
-
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-
-
29
-
-
85069138373
-
-
note
-
In the first step of esterification of (±)-1 P. cepacia lipase displayed R-stereopreference affording (-)-2 whose ee progressively lowered to give a quasi-racemic 2 that accumulated in the reaction mixture before subsequent enantioselective acylation. Selected experiments established that C. antarctica lipase and M. miehei lipase showed S-stereopreference in both steps of the acylation of (±)-1, so at very low levels of conversion monoacetate 2 was slightly enriched in the 5-enantiomer (+)-2.
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