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Volumn 10, Issue 14, 1999, Pages 2651-2654

Kinetic resolution of 1,2-dihydroxy-3-ferrocenylpropane by sequential lipase-catalysed esterification

Author keywords

[No Author keywords available]

Indexed keywords

FERROCENE DERIVATIVE; TRIACYLGLYCEROL LIPASE;

EID: 0033575388     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(99)00293-1     Document Type: Article
Times cited : (15)

References (32)
  • 26
    • 85069141010 scopus 로고    scopus 로고
    • note
    • 3OD): δ 35.10, 66.54, 68.34, 68.40, 69.45, 70.01, 70.30, 74.42, 85.95.
  • 28
    • 85069128985 scopus 로고    scopus 로고
    • note
    • 6).
  • 29
    • 85069138373 scopus 로고    scopus 로고
    • note
    • In the first step of esterification of (±)-1 P. cepacia lipase displayed R-stereopreference affording (-)-2 whose ee progressively lowered to give a quasi-racemic 2 that accumulated in the reaction mixture before subsequent enantioselective acylation. Selected experiments established that C. antarctica lipase and M. miehei lipase showed S-stereopreference in both steps of the acylation of (±)-1, so at very low levels of conversion monoacetate 2 was slightly enriched in the 5-enantiomer (+)-2.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.