Cytokine-based gene therapy of human tumors. An overview

Folia Biologica

Volumn 42, Issue 6, 1996, Pages 305-309

  Parmiani, G ^a   Arienti, F ^c   Sule Suso J ^b   Melani, C ^c   Colombo, M P ^c   Ramakrishna, V ^c   Belli, F ^c   Mascheroni, L ^c   Rivoltini, L ^c   Cascinelli, N ^c  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY HOSPITALS OF NORTH MIDLANDS NHS TRUST   (United Kingdom)

^c NONE

Author keywords

Cytokines; Gene therapy; Tumors

Indexed keywords

ANIMALIA;

B7 ANTIGEN; CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 4; TUMOR VACCINE; CANCER VACCINE; RECOMBINANT PROTEIN; RECOMBINANT VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER GENETICS; CANCER IMMUNIZATION; CANCER IMMUNOLOGY; CANCER INHIBITION; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; ERYTHEMA; FEVER; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOGENETICS; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; PHENOTYPE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; EXPERIMENTAL NEOPLASM; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; NEOPLASM; REVIEW;

ANIMALS; ANTIGENS, CD80; CANCER VACCINES; CYTOKINES; GENE THERAPY; HUMANS; INTERLEUKIN-2; INTERLEUKIN-4; MELANOMA; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; VACCINES, SYNTHETIC;

EID: 0030325073     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Review

References (21)

1. Allione, A., Consalvo, M., Nanni, P., Lollini, P. L., Cavallo, F., Giovareli, M., Forni, G., Gulino, A., Colombo, M. P., Dellabona, P., Hock, H., Blankestein, T., Rosenthal, F. M., Gansbacher, B., Bosco, M. C., Musso, T., Gusella, L., Forni, G. (1994) Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor, granulocyte-macrophage-colony stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants. Cancer Res. 54, 6022-6026.
2. Arienti, F., Sulé-Suso, J., Melani, C., Maccalli, C., Belli, F., Illeni, M. T., Anichini, A., Cascinelli, N., Colombo, M. P., Parmiani, G. (1994) Interleukin-2 gene-transduced human melanoma cells efficiently stimulate MHC-unrestricted and MHC-restricted autologous lymphocytes. Hum. Gene Ther. 5, 1139-1150.
3. Baskar, S., Clements, V. K., Glimcher, L. H., Ostrand-Rosenberg, S. (1996) Rejection of MHC class II-transfected tumor cells requires induction of tumor-encoded B7-1 and/or B7-2 costimulatory molecules. J. Immunol. 156, 3821-3827.
4. Bubeník, J., Voitenok, N. N., Kieler, J. (1988) Local administration of cells containing an inserted IL-2 gene and producing IL-2 inhibits growth of human tumors in nu/nu mice. Immunol. Lett. 19, 279-282.
5. Cascinelli, N., Foa', R., Parmiani, C. (1994) Active immunization of metastatic melanoma patients with interleukin-4 transduced, allogeneic melanoma cells. A phase I-II study. Hum. Gene Ther. 5, 1059-1064.
6. Colombo, M. P., Modesti, A., Parmiani, G., Forni, G. (1992) Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk. Cancer Res. 52, 4853-4857.
7. Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D., Mulligan, R. C. (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, and long lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA 90, 3539-3543.
8. Hock, H., Dorsch, M., Kunzendorf, U., Überla, K., Qin, Z., Diamantstein, T., Blankestein, T. (1993) Vaccinations with tumor cells genetically engineered to produce different cytokines: effectivity not superior to a classical adjuvant. Cancer Res. 53, 714-716.
9. Huang, A. Y. C., Bruce, A. T., Pardoll, D. M., Levitsky, H. I. (1996) Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo ? J. Exp. Med. 183, 769-776.
10. Huang, A. Y. C., Golumbek, P., Ahmadzadeh, M., Jaffee, E., Pardoll, D., Levitsky, H. (1994) Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264, 961-965.
11. Maas, G., Schmidt, W., Berger, M., Schilcher, F., Koszik, F., Schneeberger, A., Stingl, G., Birnstiel, M. L., Schweighoffer, T. (1995) Priming of tumor-specific T cells in the draining lymph nodes after immunization with interleukin 2-secreting tumor cells: three consecutive stages may be required for successful tumor vaccination. Proc. Natl. Acad. Sci. USA 92, 5540-5544.
12. Melani, C., Sulé-Suso, J., Arienti, F., Maccalli, C., Passerini, F., Colombo, M. P., Parmiani, G. (1995) A human melanoma cell line transduced with an interleukin-4 gene by a retroviral vector releases biologically active IL-4 and maintains the original tumor antigenic phenotype. Hum. Gene Ther. 6, 1427-1436.
13. Oldfield, E. H., Ram, Z., Culver, K. W., Blaese, R. M., DeVroom, H. L., Anderson, W. F. (1993) Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum. Gene Ther. 4, 39-69.
14. Parmiani, G., Colombo, M. P. (1995) Somatic gene therapy of human melanoma: preclinical studies and early clinical trials. Melanoma Res. 5, 295-301.
15. Parmiani, G., Colombo, M. P., Melani, C., Arienti, F. (1996) Cytokine gene transduction in the immunotherapy of cancer. Adv. Pharmacol., in press.
16. Ram, Z., Walbridge, S., Shawaker, T., Culver, K. W., Blaese, R. M., Oldfield, E. H. (1994) The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats. J. Neurosurg. 81, 256-260.
17. Rosenfeld, M. E., Feng, M., Michael, S. I., Siegal, G. P., Alvarez, R. D., Curiel, D. T. (1995) Adenoviral-mediated delivery of the herpes simplex virus thymidine kinase gene selectively sensitizes human ovarian carcinoma cells to ganciclovir. Clin. Cancer Res. 1, 1571-1580.
18. Roth, J. A., Mukhopadhyay, T., Zhang, W.-W., Fujiwara, T., Georges, R. (1995) Gene replacement strategies for the prevention and therapy of cancer. In: The Internet Book of Gene Therapy. Cancer Therapeutics, eds. Sobol, R. E., Scanlon, K. J., pp. 229-234, Appleton and Lange, Stamford.
19. Sobol, R. E., Scanlon, K. J., eds. (1995) The Internet Book of Gene Therapy. Cancer Therapeutics. Appleton and Lange, Stamford.
20. Sulé-Suso, J., Arienti, F., Melani, C., Colombo, M. P., Parmiani, G. (1995) A B7-1-transfected human melanoma line stimulates proliferation and cytotoxicity of autologous and allogeneic lymphocytes. Eur. J. Immunol. 25, 2737-2742.
21. Uchiyama, A., Hoon, D. S. B., Marisaki, T., Kaned, Y., Yuzuki, D., Morton, D. L. (1993) Transfection of interleukin-2 gene into human melanoma cells augments cellular immune response. Cancer Res. 53, 949-952.