The superantigen Staphylococcus enterotoxin B induces a strong and accelerated secondary T-cell response rather than anergy

Immunology

Volumn 87, Issue 1, 1996, Pages 49-54

  Schultz, H ^a   Geiselhart, A ^a   Sappler, G ^a   Niethammer, D ^a   Hoffmann, M K ^b   Dannecker, G E ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN;

ANERGY; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA SYNTHESIS; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD2; CELL DIVISION; CLONAL ANERGY; CLONAL DELETION; ENTEROTOXINS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, INTERLEUKIN-2; SUPERANTIGENS; T-LYMPHOCYTE SUBSETS;

EID: 0030060233     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. JARDETZKY T.S., BROWN J.H., GORGA J.C. et al. (1994) Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature 368, 711.
2. ACHARYA K.R., PASSALACQUA E.F., JONES E.Y. et al. (1994) Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1. Nature 367, 94.
3. WHITE J., HERMAN A., PULLEN A.M., KUBO R., KAPPLER J.W. & MARRACK P. (1989) The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56, 27.
4. HERMAN A., KAPPLER J.W., MARRACK P. & PULLEN A.M. (1991) Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu Rev Immunol 9, 745.
5. ACHA-ORBEA H., HELD W., WAANDERS G.A. et al. (1993) Exogenous and endogenous mouse mammary tumor virus superantigens. Immunol Rev 131, 5.
6. a expressing cells. Nature 339, 541.
7. + T cells in Staphylococcus Enterotoxin B-primed mice. J Exp Med 172, 1065.
8. + T cells by staphylococcal enterotoxin B. J Exp Med 172, 1091.
9. + peripheral T cells responding to staphylococcal enterotoxin B in vivo. Eur J Immunol 21, 1963.
10. WEBB S., MORRIS C. & SPRENT J. (1990) Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 63, 1249.
11. a anergy in vivo. J Immunol 146, 2083.
12. LUSSOW A.R. & MACDONALD H.R. (1994) Differential effects of superantigen-induced 'anergy' on priming and effector stages of a T cell-dependent antibody response. Eur J Immunol 24, 445.
13. LEE W.T. & VITETTA E.S. (1992) Memory T cells are anergic to the superantigen Staphylococcal Enterotoxin B. J Exp Med 176, 575.
14. FLEISCHER B. & SCHERZENMEIER H. (1988) T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells. J Exp Med 167, 1697.
15. GONZALO J.A., BAIXERAS E., GONZALEZ-GARCIA A. et al. (1994) Differential in vivo effects of a superantigen and an antibody targeted to the same T cell receptor. Activation-induced cell death vs passive macrophage-dependent deletion. J Immunol 152, 1597.
16. HEEG K., BENDIGS S., MIETHKE T. & WAGNER H. (1993) Induction of unresponsiveness to the superantigen staphylococcal enterotoxin B: cyclosporin A resistant split unresponsiveness unfolds in vivo without preceding clonal expansion. International Immunology 5, 929.
17. WAHL C., MIETHKE T., HEEG K. & WAGNER H. (1993) Clonal deletion as direct consequence of an in vivo T cell response to bacterial superantigen. Eur J Immunol 23, 1197.
18. a antigens in vivo. Immunol Rev 131, 169.
19. WAANDERS G.A., LUSSOW A.R. & MACDONALD H.R. (1993) Skewed T cell receptor Vα repertoire among superantigen reactive murine T cells. International Immunology 5, 55.
20. + cells to bacterial superantigens. Eur J Immunol 22, 1935.
21. STAERZ U.D., RAMMENSEE H.-G., BENEDETTO J.D. & BEVAN M.J. (1985) Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor. J Immunol 134, 3994.
22. MECHERI S., EDIDIN M., DANNECKER G., MITTLER R.S. & HOFFMANN M.K. (1990) Immunogenic Ia-binding peptides immobilize the Ia molecule and facilitate its aggregation on the B cell membrane. Control by the Mls-1 gene. J Immunol 144, 1361.
23. HARLOW E. & LANE D. (1988) Labelling antibodies. In: Antibodies. A Laboratory Manual. (eds F. Harlow & D. Lane), p. 319. Cold Spring Harbor Laboratory, Cold Spring Harbor.
24. a selfsuperantigen. Time kinetics and MHC restriction. J Immunol 147, 2833.
25. HUESMANN M., SCOTT B., KISIELOW P. & VON BOEHMER H. (1991) Kinetics and etlicacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 66, 533.
26. HOUCK D.W. & LOKEN M.R. (1985) Simultaneous analysis of cell surface antigens, bromodeoxyuridine incorporation and DNA content. Cytometry 6, 531.
27. FRANCUS T., KLEIN R.F., STAIANO-COICO L., BECKER C.G. & SISKIND G.W. (1988) Effects of tobacco glycoprotein (TGP) on the immune system. J. Immunol 140, 1823.
28. MIETHKE T., WAHL C., HEEG K., ECHTENACHER B., KRAMMER P.H. & WAGNER H. (1992) T cell-mediated lethal shock triggered in mice by the superantigen Staphylococcal Enterotoxin B: critical role of tumor necrosis factor. J Exp Med 175, 91.
29. MOY V.T. & BRIAN A.A. (1992) Signaling by lymphocyte function-associated antigen 1 (LFA-1) in B cells: enhanced antigen presentation after stimulation through LFA-1. J Exp Med 175, 1.
30. LAGOO A.S., LAGOO-DEENADAYALAN S., LORENZ H.-M., BYRNE J., BARBER W.H. & HARDY K.J. (1994) IL-2, IL-4, and IFN-γ gene expression versus secretion in superantigen-activated T cells. J Immunol 152, 1641.
31. HEEG K., GAUS H., GRIESE D., BENDIGS S., MIETHKE T. & WAGNER H. (1995) Superantigen-reactive T cells that display an anergic phenotype in vitro appear functional in vivo. International Immunology 7, 105.
32. a does not correlate with in vivo tolerance. International Immunology 3, 923.
33. BASCHIERI S., LEES R.K., LUSSOW A.R. & MACDONALD H.R. (1993) Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cells subsets and lymphokines. Eur J Immunol 23, 2661.
34. SMITH K.A. (1988) Interleukin-2: inception, impact and implications. Science 240, 1169.
35. c chain of the IL-2 receptor. Science 266, 1039.
36. SPRINGER T.A. (1990) Adhesion receptors of the immune system. Nature 346, 425.
37. SPRUYT L.L., GLENNIE M.J., BEYERS A.D. & WILLIAMS A.F. (1991) Signal transduction by the CD2 antigen in T cells and natural killer cells: requirement for expression of a functional T cell receptor or binding of antibody Fc to the Tc receptor, FcFRIIA (CD16). J Exp Med 174, 1407.
38. BAIXERAS E., BOSCA L., STAUBER C. et al. (1994) From apoptosis to autoimmunity: insights from the signalling pathways leading to proliferation or to programmed cell death. Immunol Rev 142, 53.
39. OHNISHI H., TANAKA T., TAKAHARA J. & KOTB M. (1993) Cd28 delivers costimulatory signals for superantigen-induced activation of antigen-presenting cell-depleted human T-lymphocytcs. J Immunol 150, 3207.
40. RÖCKEN M., URBAN J.F. & SHEVACH E.M. (1992) Infection breaks T-cell tolerance. Nature 359, 79.
41. MCCORMACK J.E., KAPPLER J. & MARRACK P. (1994) Stimulation with specific antigen can block superantigen-mediated deletion of T cells in vivo. Proc Natl Acad Sci USA 91, 2086.