Polycitone A, a novel and potent general inhibitor of retroviral reverse transcriptases and cellular DNA polymerases

Biochemical Journal

Volumn 344, Issue 1, 1999, Pages 85-92

  Loya, Shoshana ^a   Rudi, Amira ^a   Kashman, Yoel ^a   Hizi, Amnon ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

DNA binding; Polycitrin A; Reverse transcriptase inhibitor; Toxiusol

Indexed keywords

AROMATIC COMPOUND; DNA DIRECTED DNA POLYMERASE; DNA POLYMERASE; POLYCITONE A; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ASCIDIACEA; BINDING SITE; CHEMICAL MODIFICATION; COMPETITION; COMPLEX FORMATION; DNA BINDING; ENZYME INHIBITION; ENZYME KINETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; RETROVIRUS;

ALKALOIDS; ANIMALS; BASE SEQUENCE; CATTLE; DNA PRIMERS; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; KINETICS; LEUKEMIA VIRUS, MURINE; MAMMARY TUMOR VIRUS, MOUSE; MICE; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; UROCHORDATA;

EID: 0033571010     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3440085     Document Type: Article

References (51)

1. Barre-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Chamaret, S., Gruest, J., Daguet, C., Axler-Blin, C., Vezinet-Brun, F., Rouzioux, C. Rozenbaum, W. and Montagnier, L. (1983) Science 220, 868-871
2. Gallo, R. C., Salahuddin, S. Z., Popovic, M., Shearer, G. M., Kaplan, M., Haynes, B. F., Palker, T. J., Redfield, R., Oleske, J. and Safai, B. et al. (1984) Science 224, 500-503
3. De Clercq, E. (1992) AIDS Res. Hum. Retroviruses 8, 119-134
4. Mitsuya, H. and Broder, S. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 1911-1915.
5. Reardon, J. E. and Miller, W. H. (1990) J. Biol. Chem. 265, 20302-20307
6. Richmann, D. D., Fischl, M. A., Grieco, M. H., Gotlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Grooman, J. E., Mildvan, D. and Hirsch, M. S. et al. (1987) N. Engl. J. Med. 317, 192-197
7. Fischl, M. A., Richman, D. D., Causey, D. M., Grieco, M. H., Bryson, Y., Mildvan, D., Laskin, O. L., Groopman, J. E., Volberding, P. A. and Shooley, R. T., et al. (1989) J. Am. Med. Assoc. 262, 2405-2410
8. Larder, B. A. and Kemp, S. D. (1989) Science, 246, 1155-1158
9. Larder, B. A., Darby, G. and Richman, D. D. (1989) Science 243, 1731-1734
10. De Clercq, E. (1996) Med. Res. Rev. 16, 125-157
11. Yuasa, S., Sadakata, Y., Takashima, H., Sekiya, K., Inouya, N., Ubasawa, M. and Baba, M. (1993) Mol. Pharmacol. 44, 895-900
12. Loya, S. and Hizi, A. (1990) FEBS Lett. 269, 131-134
13. Loya, S., Tal, R., Kashman, Y. and Hizi, A. (1990) Antimicrob. Agents Chemother. 34, 2009-2012
14. Loya, S., Kashman, Y. and Hizi, A. (1992) Arch. Biochem. 293, 208-212
15. Loya, S., Rudi, A., Tal, R., Kashman, Y., Loya, Y. and Hizi, A. (1994) Arch. Biochem. Biophys. 309, 315-322
16. Loya, S., Bakhanashvili, M., Kashman, Y. and Hizi, A. (1995) Arch. Biochem. Biophys. 316, 789-796
17. Loya, S., Bakhanashvili, M., Kashman, Y. and Hizi, A. (1995) Biochemistry 34, 2260-2266
18. Loya, S., Rudi, A., Kashman, Y. and Hizi, A. (1997) Biochem. J. 324, 721-727
19. Rudi, A., Goldberg, I., Stein, Z., Frolow, F., Benayhu, Y., Schleyer, M. and Kashman, Y. (1994) J. Org. Chem. 59, 999-1003
20. Shaharabany, M. and Hizi, A. (1991) AIDS Res. Hum. Retroviruses 7, 883-888.
21. Hizi, A., McGill, C. and Hughes, S. H. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 1218-1222
22. Clark, P. K., Ferris, A. L., Miller, D. A., Hizi, A., Kim, K. W., Dringer-Boyer, S. M., Mellini, M. L., Clark, Jr., A. D., Arnold, G. F., Lebherz, W. B., Arnold, E., Muschik, G. M. and Hughes, S. H. (1990) AIDS Res. Hum. Retroviruses 6, 753-764
23. Taube, R., Loya, S., Avidan, O., Perach, M. and Hizi, A. (1998) Biochem. J. 329, 579-587
24. Hizi, A., Tal, R., Shaharabany, M. and Loya, S. (1991) J. Biol. Chem. 266, 6230-6239
25. Avidan, O. and Hizi, A. (1998) Nucl. Acids Res. 26, 1713-1717
26. Bakhanashvili, M. and Hizi, A. (1994) Biochemistry 33, 1222-1228
27. Debyser, Z., Pauwels, R., Andries, K., Desmyter, J., Kukla, M., Janssen, P. A. J. and De Clercq, E. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 1451-1455
28. Majumadar, C., Abbots, J., Broder, S. and Wilson, S. H. (1988) J. Biol. Chem. 263, 15657-15665
29. Vogt, V. M. (1997) In Retroviruses Retroviral Virions and Genomes (Coffin, M. J., Hughes, S. H. and Varmus, E. H., eds), pp. 27-69, Cold Spring Harbor Laboratory Press, New York
30. Balzarini, J., Petez-Perez, M.-J., San-Felix, A., Camarosa, M.-J., Bathurst, I. C., Barr, P. J. and De Clercq (1992) J. Biol. Chem. 267, 11831-11836
31. De Clercq, E. (1995) Clinical Microbiol. Rev. 8, 200-239
32. Spence, R. A., Kati, W. M., Anderson, K. S. and Johnson, K. A. (1995) Science 267, 988-993
33. Hopkins, L. A., Ren, J., Esnouf, R. M., Willcox, B. E., Tanaka, H., Stammens, D. K. and Stuart, D. I. (1996) J. Med. Chem. 39, 1589-1600
34. Arnold, E., Das, K., Ding, J., Yadav, P. N. S., Hsious, Y., Boyer, P. L. and Hughes, S. H. (1996) Drug Design Discovery 13, 19-47
35. Tantillo, C., Ding, J., Jacobo-Molina, A., Nanni, R. G., Boyer, P. L., Hughes, S. H., Pauwels, R., Andries, K., Janssen, P. A. J. and Arnold, E. (1994) J. Mol. Biol. 243, 369-387
36. Boyer, P. L., Tantillo, C., Jacobo-Molina, A., Nanni, R. G., Ding, J., Arnold, E. and Hughes, S. H. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 4882-4886
37. Perach, M., Rubinek, T., Hughes, S. H. and Hizi, A. (1997) J. Mol. Biol. 268, 648-654
38. Kati, M. W., Johnson, K. A., Jerva, L. F. and Andersson, K. S. (1992) J. Biol. Chem. 39, 1589-1600
39. Reardon, J. E. (1992) Biochemistry 31, 4473-4479
40. Hsieh, J., Zinner, S. and Modrick, P. (1993) J. Biol. Chem. 268, 24607-24613
41. Joyce, C. M. and Steitz, T. A. (1994) Annu. Rev. Biochem. 63, 777-822
42. Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A. and Steitz, T. A. (1992) Science 256, 1783-1790
43. Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, Jr., A. D., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., Hizi, A., Hughes, S. H. and Arnold, E. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 6320-6324
44. Davies, J. F., Almassy, R. J., Hostomsky, Z., Ferre, R. A. and Holomsky, Z. (1994) Cell 76, 1123-1133
45. Sawaya, M. R., Perlletier, H., Kumar, A., Wilson, S. H. and Krant, J. (1994) Science 264, 1930-1935
46. Georgiadis, M. M., Jessen, S. M., Ogata, C. M., Telesnitsky, A., Goff, S. P. and Hendrickson, W. A. (1995) Structure (London) 3, 879-892
47. Sousa, R. (1996) Trends Biochem. Sci. 21, 186-190
48. Patel, P. H., Jacobo-Molina, A., Ding, J., Tantillo, C., Clark, Jr., A. D., Raag, R., Nanni, R. G., Hughes, S. H. and Arnold, E. (1995) Biochemistry 34, 5351-5363
49. Pellitier, H., Sawaya, M. R., Kumar, A., Wilson, S. H. and Kraut, J. (1994) Science 264, 1891-1903
50. Steitz, T. A. (1993) Curr. Opin. Struct. Biol. 3, 31-38
51. Bakhanashvili, M. and Hizi, A. (1992) Biochemistry 31, 9393-9398