Effects of testosterone on the development of a sexually dimorphic neuromuscular system in ciliary neurotrophic factor receptor knockout mice

Journal of Neurobiology

Volumn 41, Issue 3, 1999, Pages 317-325

  Park, Joong Jean ^a   Howell, Michelle ^a   Winseck, Adam ^a   Forger, Nancy G ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Androgen; Motoneuron; Neurotrophic factor; Sexual dimorphism; Spinal cord

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; OIL; RECEPTOR; TESTOSTERONE; TESTOSTERONE PROPIONATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENOTYPE; MOTONEURON; MOUSE; MUSCLE DEVELOPMENT; MUSCLE MASS; NEUROMUSCULAR SYSTEM; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

ANIMALS; CELL COUNT; CELL SIZE; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR NEURONS; MUSCLE, SKELETAL; PERINEUM; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; RESEARCH DESIGN; SEX CHARACTERISTICS; SPINAL CORD; TESTOSTERONE;

EID: 0033570940     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4695(19991115)41:3<317::AID-NEU1>3.0.CO;2-X     Document Type: Article

References (53)

1. Arakawa Y, Sendtner M, Thoenen H. 1990. Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J Neurosci 10:3507-3515.
2. Barbin G, Manthorpe M, Varon SJ. 1984. Purification of the chick eye ciliary neuronotrophic factor. J Neurochem 43:1468-1478.
3. Boudreau-Larivière C, Sveistrup H, Parry DJ, Jasmin BJ. 1996. Ciliary neurotrophic factor: regulation of acetylcholinesterase in skeletal muscle and distribution of messenger RNA encoding its receptor in synaptic versus extrasynaptic compartments. Neuroscience 73:613-622.
4. Breedlove SM, Arnold AP. 1980. Hormone accumulation in a sexually dimorphic motor nucleus in the rat spinal cord. Science 210:564-566.
5. Breedlove SM, Arnold AP. 1983. Hormonal control of a developing neuromuscular system. II. Sensitive periods for the androgen-induced masculinization of the rat spinal nucleus of the bulbocavernosus. J Neurosci 3:424-432.
6. Cihak R, Gutmann E, Hanzlikova V. 1970. Involution and hormone-induced persistence of the muscle sphincter (levator) ani in female rats. J Anat (Lond) 106:93-110.
7. Davies AM. 1996. Paracrine and autocrine actions of neurotrophic factors. Neurochem Res 21:749-753.
8. Davis S, Aldrich TH, Stahl N, Pan L, Taga T, Kishimoto T, Ip NY, Yancopoulos GD. 1993. LIFRβ and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 260:1805-1808.
9. Davis S, Aldrich TH, Valenzuela DM, Wong V, Furth ME, Squinto SP, Yancopoulos GD. 1991. The receptor for ciliary neurotrophic factor. Science 253:59-63.
10. DeChiara TM, Vejsada R, Poueymirou WT, Acheson A, Suri C, Conover JC, Friedman B, McClain J, Pan L, Stahl N, Ip NY, Kato A, Yancopoulos GD. 1995. Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83:313-322.
11. Fishman RB, Breedlove SM. 1988. Neonatal androgen maintains sexually dimorphic motoneurons in the absence of innervation. Muscle Nerve 11:553-560.
12. Fishman RB, Chism L, Firestone GL, Breedlove SM. 1990. Evidence for androgen receptors in sexually dimorphic perineal muscles of neonatal male rats: absence of androgen accumulation by the perineal motoneurons. J Neurobiol 21:694-704.
13. Forger NG, Howell ML, Bengston L, MacKenzie L, DeChiara TM, Yancopoulos GD. 1997. Sexual dimorphism in the spinal cord is absent in mice lacking the ciliary neurotrophic factor receptor. J Neurosci 17:9605-9612.
14. Forger NG, Roberts SL, Wong V, Breedlove SM. 1993. Ciliary neurotrophic factor maintains motoneurons and their target muscles in developing rats. J Neurosci 13: 4720-4726.
15. Forger NG, Wong V, Breedlove SM. 1995. Ciliary neurotrophic factor arrests muscle and motoneuron degeneration in androgen-insensitive rats. J Neurobiol 28:354-362.
16. Freeman LM, Watson NV, Breedlove SM. 1997. Androgen spares androgen-insensitive motoneurons from apoptosis in the spinal nucleus of the bulbocavernosus in rats. Hormone Behav 30:424-433.
17. Gomori G. 1950. A rapid one-step trichrome stain. Am J Clin Pathol 20:662-664.
18. Gondos B. 1980. Development and differentiation of the testis and male reproductive tract. In: Steinberger A, Steinberger E, editors. Testicular development, structure, and function. New York: Raven Press. p 3-20.
19. Guillet C, Auguste P, Mayo W, Kreher P, Gascan H. 1999. Ciliary neurotrophic factor is a regulator of muscular strength in aging. J Neurosci 19:1257-1262.
20. Haase G, Kennel P, Pettmann B, Vigne E, Akli S, Revah F, Schmalbruch H, Kahn A. 1997. Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors. Nat Med 3:429-436.
21. Helgren ME, Squinto SP, Davis HL, Parry DJ, Boulton TG, Heck CS, Zhu Y, Yancopoulos GD, Lindsay RM, DiStefano PS. 1994. Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle. Cell 76:493-504.
22. Henderson JT, Seniuk NA, Richardson PM, Gauldie J, Roder JC. 1994. Systemic administration of ciliary neurotrophic factor induces cachexia in rodents. J Clin Invest 93:2632-2638.
23. Ikeda K, Wong V, Holmlund TH, Greene T, Cedarbaum JM, Lindsay RM, Mitsumoto H. 1995. Histomeric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease. Ann Neurol 37:47-54.
24. Ip FCF, Fu AKY, Tsim KWK, Ip NY. 1995. Cloning of the a component of the chick ciliary neurotrophic factor receptor: developmental expression and down-regulation in denervated skeletal muscle. J Neurochem 65:2393-2400.
25. Ip NY, McClain J, Barrezueta NX, Aldrich TH, Pan L, Li Y, Wiegand SJ, Friedman B, Davis S, Yancopoulos GD. 1993. The a component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Cell 10:89-102.
26. Jordan CL, Padgett B, Hershey J, Prins G, Arnold A. 1997. Ontogeny of androgen receptor immunoreactivity in lumbar motoneurons and in the sexually dimorphic levator ani muscle of male rats. J Comp Neurol 379:88-98.
27. Lin L-FH, Mismer D, Lile JD, Armes LG, Butler ET, Vannice JL, Collins F. 1991. Purification, cloning, and expression of ciliary neurotrophic factor (CNTF). Science 246:1023-1025.
28. MacLennan AJ, Vinson EN, Marks L, McLaurin DL, Pfeifer M, Lee N. 1996. Immunohistochemical localization of ciliary neurotrophic factor receptor α expression in the rat nervous system. J Neurosci 16:621-630.
29. Marques MJ, Neto HS. 1997. Ciliary neurotrophic factor stimulates in vivo myotube formation in mice. Neurosci Lett 234:43-46.
30. Martin D, Merkel E, Tucker KK, McManaman JL, Albert D, Relton J, Russel D. 1996. Cachectic effect of ciliary neurotrophic factor on innervated skeletal muscle. Am J Physiol 271:R1422-R1428.
31. Masu Y, Wolf E, Holtmann B, Sendtner M, Brem G, Thoenen H. 1993. Disruption of the CNTF gene results in motor neuron degeneration. Nature 365:27-32.
32. McKenna KE, Nadelhaft I. 1986. The organization of the pudendal nerve in the male and female rat. J Comp Neurol 248:532-549.
33. Michel RN, Campbell RJ, Jasmin BJ. 1996. Regulation of succinate dehydrogenase within muscle compartments by nerve-mediated activity and CNTF. Am J Physiol 270: R80-R85.
34. Mitsumoto H, Ikeda K, Klinkosz B, Cedarbaum JM, Wong V, Lindsay RM. 1994. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science 265:1107-1110.
35. Nordeen EJ, Nordeen KW, Sengelaub DR, Arnold AP. 1985. Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus. Science 229:671-673.
36. Ohta M, Ohi T, Nishimura M, Itoh N, Hayashi K, Ohta K. 1996. Distribution of and age-related changes in ciliary neurotrophic factor protein in rat tissues. Biochem Mol Biol Int 40:671-678.
37. Oppenheim R, Prevette D, Qin-Wei Y, Collins F, MacDonald J. 1991. Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor. Science 251: 1616-1618.
38. Pointis G, Latreille M-T, Cedard L. 1980. Gonado-pituitary relationships in the fetal mouse at various times during sexual differentiation. J. Endocrinol 86:483-488.
39. Sachs BD. 1982. Role of the rat's striated penile muscles in penile reflexes, copulation and the induction of pregnancy. J Reprod Fertil 66:433-443.
40. Sachs BD, Thomas DA. 1985. Differential effects of perinatal androgen treatments on sexually dimorphic characteristics in rats. Physiol Behav 34:735-742.
41. Sagot Y, Tan SA, Baetge E, Schmalbruch H, Kato AC, Aebischer P. 1995. Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse. Eur J Neurosci 7:1313-1322.
42. Schroder HD. 1980. Organization of the motoneurons innervating the pelvic muscles of the male rat. J Comp Neurol 192:567-587.
43. Sendtner M, Kreutzberg GW, Thoenen H. 1990. Ciliary neurotrophic factor prevents the degeneration of motor axons after axotomy. Nature 345:440-441.
44. Sendtner M, Schmalbruch H, Stöckli KA, Carroll P, Kreutzberg GW, Thoenen H. 1992. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358:502-504.
45. Shelton DL. 1996. Are there more members of the CNTF-GPA family? Perspect Dev Neurobiol 4:101-107.
46. Stöckli KA, Lottspeich F, Sendtner M, Masiakowski P, Carroll P, Götz R, Lindholm D, Thoenen H. 1989. Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor. Nature 342:920-923.
47. Wagner CK, Clemens LG. 1989a. Anatomical organization of the sexually dimorphic perineal neuromuscular system in the house mouse. Brain Res 499:93-100.
48. Wagner CK, Clemens LG. 1989b. Perinatal modification of a sexually dimorphic motor nucleus in the spinal cord of the B6D2F1 House Mouse. Physiol Behav 45:831-835.
49. Wallach SJR, Hart BJ. 1983. The role of the striated penile muscles of the male rat in seminal plug dislodgement and deposition. Physiol Behav 31:815-821.
50. Ward IL, Weisz J. 1980. Maternal stress alters plasma testosterone in fetal males. Science 207:328-329.
51. Wee BEF, Clemens LG. 1987. Characteristics of the spinal nucleus of the bulbocavernosus are influenced by genotype in the house mouse. Brain Res 424:305-310.
52. Weis J, Lie DC, Ragoss U, Zuchner SL, Schroder JM, Karpati G, Farruggella T, Stahl N, Yancopoulos GD, DiStefano PS. 1998. Increased expression of CNTF receptor alpha in denervated human skeletal muscle. J Neuropathol Exp Neurol 57:850-857.
53. Xu J, Forger NG. 1998. Expression and androgen regulation of the ciliary neurotrophic factor receptor (CNTFRα) in muscles and spinal cord. J Neurobiol 35:217-225.