Activated G(α) subunits can inhibit multiple signal transduction pathways during Dictyostelium development

Developmental Biology

Volumn 215, Issue 2, 1999, Pages 443-452

  Srinivasan, Jaishree ^a   Gundersen, Robert E ^b   Hadwiger, Jeffrey A ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MAINE   (United States)

Author keywords

Chemotaxis; Development; Dictyostelium; G protein

Indexed keywords

CYCLIC AMP; FOLIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN;

ALPHA CHAIN; ARTICLE; CARCINOGENESIS; CELL AGGREGATION; CELL MATURATION; CELL MOTION; CHEMOTAXIS; DICTYOSTELIUM; ENZYME ACTIVITY; GENE CONSTRUCT; GENE MUTATION; GENE OVEREXPRESSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; MUTATION; PHYSIOLOGY;

DICTYOSTELIUM; EUKARYOTA;

ANIMALS; CHEMOTAXIS; CYCLIC AMP; DICTYOSTELIUM; FOLIC ACID; GTP-BINDING PROTEINS; MUTATION; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 0033570377     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1999.9474     Document Type: Article

References (46)

1. Blusch J., Morandini P., Nellen W. Transcriptional regulation by folate: Inducible gene expression in Dictyostelium transformants during growth and early development. Nucleic Acids Res. 20:1992;6235-6238.
2. Bourne H. R., Sanders D. A., McCormick F. The GTPase superfamily: Conserved structure and molecular mechanism. Nature. 349:1991;117-127.
3. Brandon M. A., Podgorski G. J. G alpha 3 regulates the cAMP signaling system in Dictyostelium. Mol. Biol. Cell. 8:1997;1677-1685.
4. Brandon M. A., Voglmaier S., Siddiqi A. A. Molecular characterization of a Dictyostelium G-protein alpha-subunit required for development. Gene. 200:1997;99-105.
5. de Wit R. J., Rinke de Wit T. F. Developmental regulation of the folic acid chemosensory system in Dictyostelium discoideum. Dev. Biol. 118:1986;385-391.
6. Devreotes P. N. G protein-linked signaling pathways control the developmental program of Dictyostelium. Neuron. 12:1994;235-241.
7. Dharmawardhane S., Cubitt A., Clark A., Firtel R. Regulatory role of the Gα1 subunit in controlling cellular morphogenesis in Dictyostelium. Development. 120:1994;3549-3561.
8. Dohlman H. G., Song J., Apanovitch D. M., DiBello P. R., Gillen K. M. Regulation of G protein signalling in yeast. Semin. Cell. Dev. Biol. 9:1998;135-141.
9. Dynes J. L., Firtel R. A. Molecular complementation of a genetic marker in Dictyostelium using a genomic DNA library. Proc. Natl. Acad. Sci. USA. 86:1989;7966-7970.
10. Feinberg A. P., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:1983;6-13.
11. Firtel R. A. Integration of signaling information in controlling cell-fate decisions in Dictyostelium. Genes Dev. 9:1995;1427-1444.
12. Firtel R. A., van H. P., Kimmel A. R., Devreotes P. N. G protein linked signal transduction pathways in development: Dictyostelium as an experimental system. Cell. 58:1989;235-239.
13. Gundersen R. E. Phosphorylation of the G protein alpha-subunit, G alpha 2, of Dictyostelium discoideum requires a functional and activated G alpha 2. J. Cell. Biochem. 66:1997;268-276.
14. Hadwiger J. A., Firtel R. A. Analysis of Gα4, a G-protein subunit required for multicellular development in Dictyostelium. Genes Dev. 6:1992;38-49.
15. Hadwiger J. A., Lee S., Firtel R. A. The G alpha subunit G alpha 4 couples to pterin receptors and identifies a signaling pathway that is essential for multicellular development in Dictyostelium. Proc. Natl. Acad. Sci. USA. 91:1994;10566-10570.
16. Hadwiger J. A., Natarajan K., Firtel R. A. Mutations in the Dictyostelium heterotrimeric G protein α subunit Gα5 alter the kinetics of tip morphogenesis. Development. 122:1996;1215-1224.
17. Hadwiger J. A., Srinivasan J. Folic acid stimulation of the Gα4 G protein-mediated signal transduction pathway inhibits anterior prestalk cell development in Dictyostelium. Differentiation. 64:1999;195-204.
18. Hadwiger J. A., Wilkie T. M., Strathmann M., Firtel R. A. Identification of Dictyostelium Gα genes expressed during multicellular development. Proc. Natl. Acad. Sci. USA. 88:1991;8213-8217.
19. Hepler J. R., Berman D. M., Gilman A. G., Kozasa T. RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proc. Natl. Acad. Sci. USA. 94:1997;428-432.
20. Hermouet S., Merendino J. J. Jr., Gutkind J. S., Spiegel A. M. Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells. Proc. Natl. Acad. Sci. USA. 88:1991;10455-10459.
21. Hildebrandt J. D. Role of subunit diversity in signaling by heterotrimeric G proteins. Biochem. Pharmacol. 54:1997;325-339.
22. Kalinec G., Nazarali A. J., Hermouet S., Xu N., Gutkind J. S. Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. Mol. Cell. Biol. 12:1992;4687-4693.
23. Kumagai A., Hadwiger J. A., Pupillo M., Firtel R. A. Molecular genetic analysis of two G alpha protein subunits in Dictyostelium. J. Biol. Chem. 266:1991;1220-1228.
24. Kumagai A., Pupillo M., Gundersen R., Miake L. R., Devreotes P. N., Firtel R. A. Regulation and function of G alpha protein subunits in Dictyostelium. Cell. 57:1989;265-275.
25. Kunkel T. A. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA. 82:1985;488-492.
26. Landis C. A., Masters S. B., Spada A., Pace A. M., Bourne H. R., Vallar L. GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature. 340:1989;692-696.
27. Lilly P., Wu L., Welker D. L., Devreotes P. N. A G-protein beta-subunit is essential for Dictyostelium development. Genes Dev. 7:1993;986-995.
28. Loomis W. F. The Development of Dictyostelium discoideum. 1982;Academic Press, New York.
29. Lyons J., Landis C., Harsh G. Two G protein oncogenes in human endocrine tumors. Science. 249:1995;655-659.
30. Mann S. K., Firtel R. A. A developmentally regulated, putative serine/threonine protein kinase is essential for development in Dictyostelium. Mech. Dev. 35:1991;89-101.
31. Neer E. J. Heterotrimeric G proteins: Organizers of transmembrane signals. Cell. 80:1995;249-257.
32. Okaichi K., Cubitt A. B., Pitt G. S., Firtel R. A. Amino acid substitutions in the Dictyostelium Galpha subunit Galpha2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase-C. Mol. Biol. Cell. 3:1992;735-747.
33. i2 induces neoplastic transformation of Rat-1 cells. Proc. Natl. Acad. Sci. 88:1991;7031-7035.
34. Parent C., Devreotes P. Molecular genetics of signal transduction in Dictyostelium. Annu. Rev. Biochem. 65:1996;411-440.
35. Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
36. Schnitzler G. R., Briscoe C., Brown J. M., Firtel R. A. Serpentine cAMP receptors may act through a G protein-independent pathway to induce postaggregative development in Dictyostelium. Cell. 81:1995;737-745.
37. Simon M. I., Strathmann M. P., Gautam N. Diversity of G proteins in signal transduction. Science. 252:1991;802-808.
38. Spiegel A. Inborn errors of signal transduction: Mutations in G proteins and G protein-coupled receptors as a cause of disease. J. Metab. Dis. 20:1997;113-121.
39. Suarez H., Du Villard J., Caillou B., Schlumberger M., Parmetier C., Monier R. Gsp mutations in human thyroid tumors. Oncogene. 6:1991;677-679.
40. Sutoh K. A transformation vector in Dictyostelium discoideum with a new selectable marker Bsr. Plasmid. 30:1993;150-154.
41. Vallar L., Spada A., Giannasttasio G. Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature. 330:1987;556-558.
42. Watson N., Linder M. E., Druey K. M., Kehrl J. H., Blumer K. J. RGS family members: GTPase-activating proteins for heterotrimeric G- protein alpha-subunits. Nature. 383:1996;172-175.
43. Wong Y., Chan J., Yung L., Bourne H. Mutant a subunit of Gz transforms Swiss 3T3 cells. Oncogene. 10:1995;1927-1933.
44. Wu L., Gaskins C., Zhou K., Firtel R. A., Devreotes P. N. Cloning and targeted mutations of G alpha 7 and G alpha 8, two developmentally regulated G protein alpha-subunit genes in Dictyostelium. Mol. Biol. Cell. 5:1994;691-702.
45. Wu L., Valkema R., Van Haastert P. J., Devreotes P. N. The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium. J. Cell Biol. 129:1995;1667-1675.
46. sα subunit gene in human endocrine tumors. Cancer. 72:1993;1386-1396.