Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: Amplification of the lytic potential by B7

Journal of Immunology

Volumn 163, Issue 6, 1999, Pages 2999-3006

  Krummel, Matthew F ^a,b   Heath, William R ^a   Allison, Janette ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD80; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033568412     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
2. Allison, J. P. 1994. CD28-B7 interactions in T-cell activation. Curr. Opin. Immunol. 6:414.
3. Linsley, P. S., W. Brady, L. Grosmaire, A. Aruffo, N. K. Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and Interleukin 2 mRNA accumulation. J. Exp. Med. 173:721.
4. Harding, F., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28 mediated signalling costimulates murine T cells and prevents the induction of anergy in T cell clones. Nature 356:607.
5. + T lymphocytes from TCR transgenic mice. J. Immunol. 152:5220.
6. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104.
7. Bachman, M. F., E. Sebzda, T. M. Kündig, A. Shahinian, D. E. Speiser, T. W. Mak, and P. S. Ohashi. 1996. T cell responses are governed by avidity and co-stimulatory thresholds. Eur. J. Immunol. 26:2017.
8. Jenkins, M. K., and R. H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302.
9. L. Immunity 3:87.
10. + helper T cells. J. Immunol. 156:1764.
11. Lucas, P. J., I. Negishi, K. Nakayama, L. E. Fields, and D. Y. Loh. 1995. Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 154:5757.
12. Kündig, T. M., A. Shahinian, K. Kawai, H-W. Mittrücker, E. Sebzda, M. F. Bachmann, T. W. Mak, and P. S. Ohashi. 1996. Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity 5:41.
13. + T cells in vitro. J. Exp. Med. 183:2247.
14. + CTLs in the absence of exogenous help. J. Exp. Med. 177:1791.
15. Azuma, M., M. Cayabyab, J. H. Phillips, and L. L. Lanier. 1993. Requirements for CD28-dependent T cell-mediated cytotoxicity. J. Immunol. 150:2091.
16. Azuma, M., M. Cayabyab, D. Buck, J. H. Phillips, and L. L. Lanier. 1992. CD28 Interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J. Exp. Med. 175:353.
17. Guerder, S., S. R. Carding, and R. A. Flavell. 1995. B7 costimulation is necessary for the activation of the lytic function of cytotoxic T lymphocyte precursors. J. Immunol. 155:5167.
18. + T cells by B7-transfected melanoma cells. Science 259:368.
19. Chen, L., S. Ashe, W. A. Brady, I. Hellstrom, K. E. Hellstrom, J. A. Ledbetter, P. McGowan, and P. S. Linsley. 1992. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 71:1093.
20. Baskar, S., S. Ostrand-Rosenberg, N. Nabavi, L. M. Nadler, G. J. Freeman, and L. H. Glimcher. 1993. Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules. Proc. Natl. Acad. Sci. USA 28271:28215.
21. Wu, T-C., A. Y. C. Huang, E. M. Jaffee, H. I. Levitsky, and D. M. Pardoll. 1995. A reassessment of the role of B7-1 expression in tumor rejection. J. Exp. Med. 182:1415.
22. Ramarathinam, L., M. Castle, Y. Wu, and Y. Liu. 1994. T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejection: an important role of B7/BB1 in the induction, recruitment, and effector function of antitumor T cells. J. Exp. Med. 179:1205.
23. Wick, M., P. Dubey, H. Koeppen, C. T. Siegel, P. E. Fields, L. Chen, J. A. Bluestone, and H. Schreiber. 1997. Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. J. Exp. Med. 186:229.
24. Allison, J., L. Stephens, T. W. Kay, C. Kurts, W. R. Heath, J. F. Miller, and M. F. Krummel. 1998. The threshold for autoimmune T cell killing is influenced by B7.1. Eur. J. Immunol. 28:949.
25. Hoquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76:17.
26. Townsend, S. E., F. W. Su, J. M. Atherton, and J. P. Allison. 1994. Specificity and longevity of antitumor immune responses induced by B7-transfected tumors. Cancer Res. 54:6477.
27. Razi-Wolf, Z., G. Freeman, F. Galvin, B. Benacerraf, L. Nadler, and H. Reiser. 1992. Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. J. Exp. Med. 89:4210.
28. Hathcock, K. S., G. Laszlo, H. B. Dickler, J. Bradshaw, P. Linsley, and R. J. Hodes. 1993. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science 262:905.
29. Bill, J., O. Kanagawa, J. Linten, Y. Utsonomiya, and E. Palmer. 1990. Class I and class II MHC gene products differentially affect the fate of Vb5 bearing thymocytes. J. Mol. Cell. Immunol. 4:269.
30. Ceredig, R., J. Lowenthal, M. Nabholz, and R. MacDonald. 1985. Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells. Nature 314:98.
31. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine-activities and secreted proteins. J. Immunol. 136:2348.
32. Trowbridge, I., J. Lesley, R. Schulte, R. Hyman, and J. Trotter. 1982. Biochemical characterization and cellular distribution of a polymorphic, murine cell surface glycoprotein expressed on lymphoid tissues. Immunogenetics 15:299.
33. Gallatin, W. M., I. Weissman, and E. Butcher. 1983. A cell surface molecule involved in organ specific homing of lymphocytes. Nature 304:30.
34. Brossart, P., and M. J. Bevan. 1996. Selective activation of fas/fas ligand-mediated cytotoxicity by a self peptide. J. Exp. Med. 183:2449.
35. Lowin, B., M. Hahne, C. Mattmann, and J. Tschopp. 1994. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370: 650.
36. Kagi, D., B. Hederman, K. Burki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31.
37. 2+ signaling modulates cytotoxic T lymphocyte effector functions. J. Exp. Med. 187:1057.
38. Mueller, D. L., M. K. Jenkins, L. Chiodetti, and R. H. Schwartz. 1990. An intracellular calcium increase and protein kinase C activation fail to initiate T cell proliferation in the absence of a costimulatory signal. J. Immunol. 144:3701.
39. Valitutti, S., M. Dessing, K. Akories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy: role of the actin cytoskeleton. J. Exp. Med. 181:577.
40. 2+-independent costimulatory activity. Eur. J. Immunol. 24:2732.
41. June, C. H., J. A. Ledbetter, T. Lindsten, and C. B. Thompson. 1989. Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes. J. Immunol. 143:153.
42. Ledbetter, J. A., M. Parsons, P. J. Martin, J. A. Hansen, P. S. Rabinovitch, and C. H. June. 1986. Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression. J. Immunol. 137:3299.
43. + T cells. J. Exp. Med. 185:641.
44. Linsley, P. S., J. L. Greene, W. Brady, J. Bajorath, J. A. Ledbetter, and R. Peach. 1994. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1:793.
45. + T cells. Cell 7:885.
46. Kurts, C., W. R. Heath, F. R. Carbone, J. Allison, J. F. A. P. Miller, and H. Kosaka. 1996. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. In press.
47. Allison, J., P. McClive, L. Oxbrow, A. Baxter, G. Morahan, and J. F. A. P. Miller. 1994. Genetic requirements for acceleration of diabetes in non-obese diabetic mice expressing interleukin-2 in islet b-cells. Eur. J. Immunol. 24:2535.
48. Allison, J., L. Oxbrow, and J. F. A. P. Miller. 1994. Consequences of in situ production of IL-2 for islet cell death. Int. Immunol. 64:541.
49. Heath, W. R., J. Allison, M. W. Hoffmann, G. Schonrich, G. Hammerling, B. Arnold, and J. F. A. P. Miller. 1992. Autoimmune diabetes as a consequence of locally produced interleukin-2. Nature 359:547.
50. Azuma, M., M. Cayabyab, D. Buck, J. H. Phillips, and L. L. Lanier. 1992. Involvement of CD28 in MHC-unrestricted cytotoxicity mediated by a human natural killer leukemia cell line. J. Immunol. 149:1115.
51. Chambers, B. J., M. Salcedo, and H. G. Ljunggren. 1996. Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1). Immunity 5:311.
52. + T cell: Receptor-dependent cytolysis in the absence of Interleukin-2 production. Science 251: 1228.
53. Noel, P. J., L. H. Boise, J. M. Green, and C. B. Thompson. 1996. CD28 costimulation prevents cell death during primary T cell activation. J. Immunol. 157:636.
54. Radvanyi, L. G., Y. Shi, H. Vaziri, A. Sharman, R. Dhala, G. B. Mills, and R. G. Miller. 1996. CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response. J. Immunol. 156:1788.
55. Daniel, P. T., A. Koidl, S. Cayeux, R. Bargou, T. Blankenstein, and B. Dörken. 1997. Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis. J. Immunol. 159:3808.