Mechanism of substrate dephosphorylation in low M(r) protein tyrosine phosphatase

Proteins: Structure, Function and Genetics

Volumn 36, Issue 3, 1999, Pages 370-379

  Kolmodin, Karin ^a   Nordlund, Pär ^b   Åqvist, Johan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Catalysis; Empirical valence bond method; Free energy perturbation; Molecular dynamics; Protein tyrosine phosphatase; Reaction free energy profile

Indexed keywords

PHOSPHORUS; PROTEIN TYROSINE KINASE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DEPHOSPHORYLATION; ENZYME MECHANISM; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTON TRANSPORT; REACTION ANALYSIS;

CATALYTIC DOMAIN; ENZYME ACTIVATION; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR WEIGHT; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN-TYROSINE-PHOSPHATASE; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 0033567033     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19990815)36:3<370::AID-PROT11>3.0.CO;2-9     Document Type: Article

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