On the Mechanism of Guanosine Triphosphate Hydrolysis in ras p21 Proteins

Biochemistry

Volumn 31, Issue 37, 1992, Pages 8691-8696

  Langen, Ralf ^a   Schweins, Thomas ^a   Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; GROWTH PROMOTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; MUTANT PROTEIN; PHOSPHATE; PROTEIN P21; PROTEIN SUBUNIT;

ARTICLE; CALCULATION; COMPUTER SIMULATION; ELECTRIC POTENTIAL; ENERGY TRANSFER; ENZYME MECHANISM; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTON TRANSPORT; THERMODYNAMICS;

GLUTAMINE; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; HYDROLYSIS; MODELS, MOLECULAR; PROTO-ONCOGENE PROTEIN P21(RAS); STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THERMODYNAMICS; WATER;

EID: 0026713142     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00152a002     Document Type: Article

References (28)

1. Adari, H., Lowy, D.R., Der, C.J., & McCormick, F. (1988) Science 240, 518-521.
2. Aqvist, J., & Warshel, A. (1989) Biochemistry 28, 4680-4688.
3. Bollag, G., & McCormick, F. (1991) Nature 351, 576-579,
4. Churg, A.K., & Warshel, A. (1986) Biochemistry 25, 1675-1681.
5. Der, C., Finkel, T., & Cooper, G. (1986) Cell 44. 167-176.
6. De Vos, A.M., Tong, L., Milburn, M., Matias, P.M., Jancarik, J., Noguchi, S., Nishimura, K., Miura, K,, Ohtsuka, E., & Kim, S.H. (1988) Science 239, 888-893.
7. Fasano, G., Aldrich, T., Tamanoi, F,, Taparowsky, E., Furth, M., & Wigler, M. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 4008-4012.
8. Feuerstein, J., Goody, R.S., & Webb, M. (1989) J. Biol. Chem. 264, 6188-6190.
9. Hwang, J.-K., &. Warshel, A. (1987) Biochemistry 26, 2669-2673.
10. Hwang, J.-K., Chu, Z.-T., Yadav, A., & Warshel, A. (1991) J. Phys. Chem. 95, 8445-8448.
11. Kraut, J. (1988) Science 242, 533-540.
12. Krengel, U., Schlichting, I., Scherer, A., Schumann, R., Freeh, M., John, J., Pai, E.F., & Wittinghofer, A. (1990) Cell 62, 539-548.
13. Langen, R., Brayer, G.D., Berghuis, A.M., McLendon, G., Sherman, F., & Warshel, A. (1992) J. Mol. Biol. 224, 589-600.
14. Lee, F.S., Chu, Z.T., Bolger, M.B., & Warshel, A. (1992) Protein Eng. 5, 215-228.
15. Milburn, M., Tong, L., De Vos, A.M., Bruenger, A., Yamaizumi, Z., Nishimura, S., & Kim, S.H. (1990) Science 247, 939-945.
16. Pai, E.F., Kabsch, W., Krengel, U., Holmes, K., John, J., & Wittinghofer, A. (1989) Nature 341, 209-214.
17. Pai, E.F., Krengel, U., Petsko, G.A., Goody, R.S., Kabsch, W., & Wittinghofer, A. (1990) EM BO J. 9, 23S1-2359.
18. Prive, G.G., Milburn, M.V., Tong, L., De Vos, A.M., Yamaizumi, Z., Nishimura, S., & Kim, S.H. (1992) Proc. Natl. Acad. Sci., U.S.A. 89, 3649-3653.
19. Sepersu, E.H., Shortle, D., & Mildvan, A.S. (1987) Biochemistry 26, 1289-1300.
20. Sigal, I.S., Marshall, M.S., Schaber, M.D., Vogel, U.S., Scolnick, E.M., & Gibbs, J.B. (1988) Cold Spring Habor Symp. Quant. Biol. S 3, 863-869.
21. Temeles, G.L., Gibbs, J.B., D'Alonzo, J.S., Sigal, I.S., & Scolnick, E.M. (1985) Nature 313, 700-703.
22. Warshel, A. (1981) Biochemistry 20, 3167-3177.
23. Warshel, A., & Russell, S. (1984) Q. Rev. Biophys. 17, 283-422.
24. Warshel, A., & Creighton, S. (1989) in Computer Simulations of Biomolecular Systems (Van Gunsteren, W.F., & Weiner, P.K., Eds.) p 120, ESCOM, Leiden, The Netherlands.
25. Warshel, A., & Aqvist, J. (1991) Annu. Rev. Biophys. Biophys. Chem. 20, 267-298.
26. Warshel, A., Sussman, F., & Hwang, J.-K. (1988) J. Mol. Biol. 201, 139-159.
27. Wells, J.A., Cunningham, B.C.,, Graycar, T.P., & Estelle, D.A. (1986) Philos. Trans. R. Soc., London, A317, 415-423.
28. Wilkinson, A.J., Fersht, A.R., Blow, D.M., Carter, C., & Winter, G. (1984) Nature 307, 187-188.