The viral protein apoptin induces apoptosis in UV-C-irradiated cells from individuals with various hereditary cancer-prone syndromes

Cancer Research

Volumn 59, Issue 12, 1999, Pages 3010-3015

  Zhang, Ying Hui ^a   Abrahams, Peter J ^a   Van Der Eb, Alex J ^a   Noteborn, Mathieu H M ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Leadd BV   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CANCER RISK; CONTROLLED STUDY; DIAGNOSTIC VALUE; DYSPLASTIC NEVUS; FAMILIAL CANCER; HUMAN; HUMAN TISSUE; PRECANCER; PRIORITY JOURNAL; RISK ASSESSMENT; TRICHOTHIODYSTROPHY; ULTRAVIOLET C RADIATION; ULTRAVIOLET IRRADIATION; XERODERMA PIGMENTOSUM;

APOPTOSIS; CAPSID; CAPSID PROTEINS; CELLS, CULTURED; CHICKEN ANEMIA VIRUS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; HUMANS; NEOPLASTIC SYNDROMES, HEREDITARY; SKIN; TIME FACTORS; ULTRAVIOLET RAYS; VIRAL PROTEINS;

EID: 0033564835     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Uren, A. G., and Vaux, D. L. Viral inhibitors of apoptosis. Vitam. Horm., 53: 175-193, 1997.
2. Shen, Y., and Shenk, T. E. Viruses and apoptosis. Curr. Opin. Genet. Dev., 5: 105-111, 1995.
3. Teodoro, J. G., and Branton, P. E. Regulation of apoptosis by viral gene products. J. Virol., 71: 1739-1746, 1997.
4. Hardwick, J. M. Virus-induced apoptosis. Adv. Pharmacol., 41: 295-336, 1997.
5. Jeurissen, S. H. M., Wagenaar, F., Pol, J. M. A., Van der Eb, A. J., and Noteborn, M. H. M. Chicken anemia virus causes apoptosis of thymocytes after in vivo infection and of cell lines after in vitro infection. J. Virol., 66: 7383-7388, 1992.
6. Noteborn, M. H. M., de Boer, G. F., Van Roozelaar, D. J., Karreman, C., Kranenburg, O., Vos, J. G., Jeurissen, S. H. M., Hoeben, R. C., Zantema, A., Koch, G., Van Ormondt. H., and Van der Eb, A. J. Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle. J. Virol., 65: 3131-3139, 1991.
7. Noteborn, M. H. M., Kranenburg, O., Zantema, A., Koch, G., De Boer, G. F., and Van der Eb, A. J. Transcription of chicken anemia virus (CAV) genome and synthesis of its 52-kDa protein. Gene (Amst.), 118: 267-271, 1992.
8. Noteborn, M. H. M., Todd, D., Verschueren, C. A. J., De Gauw, H. W. F. M., Curran, W. L., Veldkamp, S., Douglas, A. J., McNulty, M. S., Van der Eb, A. J., and Koch, G. A single chicken anemia virus protein induces apoptosis. J. Virol., 68: 346-351, 1994.
9. Zhuang, S-M., Shvarts, A., Van Ormondt H., Jochemsen, A. G., Van der Eb, A. J., and Noteborn, M. H. M. A poplin, a protein derived from chicken anemia virus, induces p53-independent apoptosis in human osteosarcoma cells. Cancer Res., 55: 486-489, 1995.
10. Danen-Van Oorschot, A. A. A. M., Zhang, Y-H., Erkeland, S., Fischer, D. F., Van der Eb, A. J., and Noteborn, M. H. M. The effect of Bcl-2 on Apoptin in normal versus transformed human cells. Leukemia (Baltimore), 13 (Suppl. 1): S75-S77, 1998.
11. Noteborn, M. H. M., Danen-van Oorschot, A. A. A. M., and Van der Eb, A. J. The Apoptin® gene of chicken anemia virus in the induction of apoptosis in human tumorigenic cells and in gene therapy of cancer. Gene Ther. Mol. Biol., 1: 399-406, 1998.
12. Danen-Van Oorschot, A. A. A. M., Fischer, D. F., Grimbergen, J. M., Klein, B., Zhuang, S-M., Falkenburg, J. H. F., Backendorf, C., Quax, P. H. A., Van der Eb, A. J., and Noteborn, M. H. M. Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. Proc. Natl. Acad. Sci. USA, 94: 5843-5847, 1997.
13. Noteborn, M. H. M., Zhang, Y-H., and Van der Eb, A. J. Apoptin® specifically causes apoptosis in tumor cells and after UV-treatment in untransformed cells from cancer-prone individuals: a review. Mutat. Res., 400: 447-455, 1998.
14. Bender, K., Blattner, C., Knebel, A., Iordanov, M., Herrlich, P., and Rahmsdorf, H. J. UV-induced signal transduction. J. Photochem. Photobiol. B., 37: 1-17, 1997.
15. Fritsche, M., Haessler, C., and Brandner, G. Induction of nuclear accumulation of tumor-suppressor protein p53 by DNA-damaging agents. Oncogene, 8: 307-318, 1993.
16. Ceraline, J., Deplanque, G., Duclos, B., Limacher, J. M., Vincent, F., Goldblum, S., and Bergerat, J. P. Relationship between p53 induction, cell cycle arrest and survival of normal human fibroblasts following DNA damage. Bull. Cancer (Paris), 84: 1007-1016, 1997.
17. Iliakis, G. Cell cycle regulation in irradiated and nonirradiated cells. Semin. Oncol., 24: 602-615, 1997.
18. Abrahams, P. J., Huitema, B. A., and van der Eb, A. J. Enhanced reactivation and enhanced mutagenesis of herpes simplex virus in normal human and xeroderma pigmentosum cells. Mol. Cell. Biol., 4: 2341-2346, 1984.
19. Abrahams, P. J., Houweling, A., Cornelissen-Steijger, P. D. M., Arwert, F., Menko, F. H., Pinedo, H. M., Terleth, C., and Van der Eb, A. J. Inheritance of abnormal expression of SOS-like response in xeroderma pigmentosum and hereditary cancer-prone syndromes. Cancer Res., 56: 2621-2625, 1996.
20. Abrahams, P. J., Houweling, A., and Van der Eb, A. J. High levels of enhanced reactivation of herpes simplex virus in skin fibroblasts from various hereditary cancer-prone syndromes. Cancer Res., 52: 53-57, 1992.
21. Malkin, D. p53 and the Li-Fraumeni syndrome. Biochim. Biophys. Acta, 1198: 197-213, 1994.
22. Srivastava, S., Zou, Z., Pirollo, K., Blattner, W., and Chang, E. H. Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature (Lond.), 348: 747-749, 1990.
23. Abrahams, P. J., Houweling, A., Cornelissen-Steijger, P. D. M., Jaspers, N. G. J., Darroudi, F., Meijers, C. M., Mullenders, L. H. F., Filon, R., Arwert, F., Pinedo, H. M., Natarajan, A. P. T., Terleth, C., Van Zeeland, A. A., and Van der Eb, A. J. Impaired DNA repair capacity in skin fibroblasts from various hereditary cancer-prone syndromes. Mutat. Res., 407: 189-201, 1998.
24. Foulkes, W. D., Flanders, T. Y., Pollock, P. H., and Hayward, N. K. The CDKN2A(p16) gene and human cancer. Mol. Med., 3: 5-20, 1997.
25. Smith-Sorensen, B., and Hovig, E. CDKN2A (p16INK4A) somatic and germline mutations. Hum. Mutat., 7: 294-303, 1996.
26. Gruis, N. A., Van der Velden, P. A., Sandkuijl, L. D., Prins, A. E., Weaver-Feldhaus, J., Kamb, A., Bergman, W., and Frants, R. R. Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds. Nat. Genet., 10: 351-353, 1995.
27. Leibowitz, E., Janniger, C. K., Schwartz, R. A., and Lambert, W. C. Xeroderma pigmentosum. Cutis, 60: 75-77, 81-84, 1997.
28. Lehmann, A. R. Cockayne's syndrome and trichothiodystrophy: defective repair without cancer. Cancer Rev., 7: 82-103, 1987.
29. Pietersen, A. M., Van der Eb, M. M., Rademaker, H. J., Van den Wollenberg, D. J. M., Rabelink, M. J. W. E., Van Ormondt, H., Masman, D., Van de Velde, C. J. H., Van der Eb, A. J., Hoeben, R. C., and Noteborn, M. H. M. Specific tumor-cell killing with adenovirus vectors containing the Apoptin gene. Gene Ther., in press, 1999.
30. Daya-Grosjean, L., Robert, C., Drougard, C., Suarez, H., and Sarasin, A. High mutation frequency in ras genes of skin tumors isolated from DNA repair-deficient xeroderma pigmentosum patients. Cancer Res., 53: 1625-1629, 1993.
31. Venkatachalam, S., Shi, Y-P., Jones, S. N., Vogel, H., Bradley, A., Pinkel, D., and Donehower, L. A. Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J., 17: 4657-4667, 1998.
32. Abrahams, P. J., van der Kleij, A. A. M., Schouten, R., and Van der Eb, A. J. Absence of induction of enhanced reactivation of herpes simplex virus in cells from xeroderma pigmentosum patients without skin cancer. Cancer Res., 48: 6054-6057, 1988.
33. Terleth, C., van Laar, T., Schouten, R., Hoedemakers, H., Wormhoudt, T., Cornelissen-Steijger, P. D. M., Abrahams, P. J., and Van der Eb, A. J. A lack of radiation-induced ornithine decarboxylase activity prevents proneness in xeroderma pigmentosum patients. Cancer Res., 57: 4384-4392, 1997.