Vasomotor responses of coronary stenoses to acetylcholine and their relation to serum lipid levels in stable angina pectoris

American Journal of Cardiology

Volumn 83, Issue 12, 1999, Pages 1606-1610

  Tousoulis, Dimitris ^a   Gorog, Diana ^a   Crake, Tom ^a   Homaei, Homeyra ^a   Ahmed, Nabeel ^a   Davies, Graham J ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CHOLESTEROL; ISOSORBIDE DINITRATE;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; BLOOD VESSEL TONE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CORONARY ARTERY OBSTRUCTION; CORRELATION FUNCTION; FEMALE; HUMAN; INTRACORONARY INFUSION; LIPID BLOOD LEVEL; MALE; PRIORITY JOURNAL; VASOMOTOR REFLEX;

ACETYLCHOLINE; ADULT; AGED; ANGINA PECTORIS; CHOLESTEROL; CORONARY ANGIOGRAPHY; CORONARY DISEASE; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROCARDIOGRAPHY; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; ISOSORBIDE DINITRATE; MALE; MIDDLE AGED; REGRESSION ANALYSIS; TRIGLYCERIDES; VASODILATOR AGENTS;

EID: 0033564722     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(99)00167-8     Document Type: Article

References (29)

1. Furchgott RF, Zawadzki JV. The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-376.
2. Vanhoutte PM. The endothelium. Modulator of vascular smooth-muscle tone. N Engl J Med 1988;319:512-513.
3. Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986;315:1046-1051.
4. Nabel EG, Ganz P, Gordon JB, Alexander WR, Selwyn AP. Dilatation of normal and constriction of atherosclerotic coronary arteries caused by cold presser test. Circulation 1988;77:43-52.
5. Werns SW, Walton JA, Hsia HH, Nabel EG, Sans ML, Pitt B. Evidence of endothelium dysfunction in angiographically normal coronary arteries in patients with coronary artery disease. Circulation 1989;79:287-291.
6. Hodgson JMcB, Marshall J. Direct vasoconstriction and endothelium-dependent vasodilation: mechanisms of acetylcholine effects on coronary flow and arterial diameter in patients with nonstenotic coronary arteries. Circulation 1989; 79:1043-1051.
7. Brown BG, Bolson EL, Dodge HT. Dynamic mechanisms in human coronary stenosis. Circulation 1984;48:797-803.
8. Zeiher AM, Drexler H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia and hypertension. J Clin Invest 1993;92:652-662.
9. Anderson TJ, Meredith IT, Charbonneau F, Yeung AC, Frei B, Selwyn AP, Ganz P. Endothelium dependent coronary vasomotion relates to the susceptibility of LDL to oxidation in humans. Circulation 1996;93:1647-1650.
10. Mougenot N, Lesnik P, Ramirez-Gil JF, Nataf P, Diczfalusy U, Chapman MJ, Lechat P. Effect of the oxidation state of LDL on the modulation of arterial vasomotor respopnse in vitro. Atherosclerosis 1997;133:183-192.
11. Zeiher A, Schachinger V, Hohnloser SH, Saurbier B, Just H. Coronary atherosclerotic wall thickening and vascular reactivity in humans: elevated high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis. Circulation 1994;89:2525-2532.
12. Egashira K, Hirooka Y, Kai H, Sugimachi M, Suzuki S, Inou T, Takeshita A. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolaemia. Circulation 1994;89:2519-2524.
13. Vita JA, Treasure CB, Nabel EG, McLenachan JM, Fish RD, Yeung AC, Vekrhtein VI, Selwyn AP, Ganz P. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990;81:491-497.
14. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. Investigation of decreased availability of nitric oxide precursor as the mechanism responsible for impaired endothelium-dependent vasodilation in hypercholesterolemic patients. J Am Coll Cardiol 1994;23:844-850.
15. Mata P, Varela O, Alonso R, Lahoz C, de-Oya M, Badimon L. Monounsaturated and polyunsaturated n-6 fatty acid-enriched diets modify LDL oxidation and decrease human coronary smooth muscle cell DNA synthesis. Arterioscler Thromb Vasc Biol 1997;17:2088-2095.
16. Raiteri M, Arnaboldi L, McGeady P, Gelb MH, Verri D, Tagliabue C, Quarato P, Ferraboschi P, Santaniello E, Paoletti R, Fumagalli R, Corsini A. Pharmacological control of the mavalonate pathway effect on arterial smooth muscle cell proliferation. J Pharmacol Exp Ther 1997;281:1144-1153.
17. Pomerantz KB, Lander HM, Summers B, Robishaw JD, Balcueva E, Hajjar DP. G-protein mediated signaling in cholesterol-enriched arterial smooth muscle cells. 1. Reduced membrane-associated G-protein content due to diminished isoprenylation of G-gamma subunits and p21ras. Biochemistry 1997;36:9523-9531.
18. Reiber JHC, Serruys PW, Koouman C, Wijns W, Slager C, Gerbrands JJ, Schuurbiers JCH, Den Boer A, Hugenholtz PG. Assessment of short-, medium, and long-term variations in arterial dimensions from computer-assisted quantitation of coronary cineangiograms. Circulation 1985;71:280-288.
19. Tousoulis D, Davies G, McFadden E, Clarke J, Kaski JC, Maseri A. Coronary vasomotor effects of setotonin in patients with angina: relationship to coronary stenosis morphology. Circulation 1993;88:1518-1526.
20. Buttery LDK, Springall DR, Chester AH, Evans TJ, Standfield N, Parums DV, Yacoub MH, Pollak JM. Inducible NO synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite. Lab Invest 1996;75:77-85.
21. Tousoulis D, Davies GJ, Tentolouris C, Crake T, Lefroy DC, Toutouzas P. Effects of inhibition of nitric oxide synthesis in patients with coronary artery disease and stable angina. Eur Heart J 1997;18:608-613.
22. Tousoulis D, Tentolouris C, Crake T, Toutouzas P, Davies GJ. Basal and flow-mediated nitric oxide production by atheromatous coronary arteries. J Am Coll Cardiol 1997;29:1256-1262.
23. Tousoulis D, Tentolouris C, Crake T, Davies G, Toutouzas P. Inhibition of nitric oxide synthesis during cold presser test in patients with coronary artery disease. Am J Cardiol 1997;79:1676-1679.
24. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial Superoxide anion production. J Clin Invest 1993;91:2546-2551.
25. Davies MJ, Thomas AC. Plaque fissuring - the cause of acute myocardial infarction, sudden ischaemic death and crescendo angina. Br Heart J 1985;53: 363-373.
26. Yasue H, Matsuyama K, Matsuyama K, Okumura K, Morikami Y, Ogawa H. Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early atherosclerosis. Circulation 1990;81:482-490.
27. Newman CM, Maseri A, Hackett D, El-Tamimi HM, Davies GJ. Response of angiographically normal and atherosclerotic left anterior descending coronary arteries to acetylcholine. Am J Cardiol 1990;66:1070-1076.
28. Okumura K, Yasue H, Matsuyama K, Ogawa H, Morikami Y, Obata K, Sakaino N. Effect of acetylcholine on the highly stenotic coronary artery: difference between the constrictor response of the infarct-related coronary artery and that of noninfarct-related artery. J Am Coll Cardiol 1992;19:752-758.
29. Kuhn FE, Mohler ER, Satler LF, Reagan K, Lu DY, Rackley CE. Effects of high density lipoprotein on acetylcholine-induced coronary vasoreactivity. Am J Cardiol 1991;68:1425-1430.