Evidence for chloramphenicol/H+ antiport in cmr (MdfA) system of Escherichia coli and properties of the antiporter

Journal of Biochemistry

Volumn 124, Issue 1, 1998, Pages 187-193

  Mine, Tomoyuki ^a   Morita, Yuji ^a   Kataoka, Atsuko ^a   Mizushima, Tohru ^a   Tsuchiya, Tomofusa ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Chloramphenicol H+; E. coli; Multidrug resistance; Sequence

Indexed keywords

ACRIDINE ORANGE; ANTIPORTER; BACTERIAL DNA; CHLORAMPHENICOL; ETHIDIUM; PROTON;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DRUG TRANSPORT; ESCHERICHIA COLI; MEMBRANE VESICLE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PLASMID; PROTON TRANSPORT; SEQUENCE HOMOLOGY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PROKARYOTA;

EID: 0031818726     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022078     Document Type: Article

References (44)

1. Nikaido, H. (1994) Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264, 382-388
2. Bentley, J., Hyatt, L.S., Ainley, K., Parish, J.H., Herbert, R.B., and White, G.R. (1993) Cloning and sequence analysis of an Escherichia coli gene conferring bicyclomycin resistance. Gene 127, 117-120
3. Lomovskaya, O. and Lewis, K. (1992) Emr, an Escherichia coli locus for multidrug resistance. Proc. Natl. Acad. Sci. USA 89, 8938-8942
4. Naroditskaya, V., Schlosser, M.J., Fang, N.Y., and Lewis, K. (1993) An E. coli gene emrD is involved in adaptation to low energy shock. Biochem. Biophys. Res. Commun. 196, 803-809
5. Yoshida, H., Bogaki, M., Nakamura, S., Ubukata, K., and Konno, M. (1990) Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones. J. Bacteriol. 172, 6942-6949
6. Rouch, D.A., Cram, D.S., DiBerardino, D., Littlejohn, T.G., and Skurray, R.A. (1990) Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. Mol. Microbiol. 4, 2051-2062
7. Neyfakh, A.A., Bidnenko, V.E., and Chen, L.B. (1991) Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system. Proc. Natl. Acad. Sci. USA 88, 4781-4785
8. Grinius, L., Dreguniene, G., Goldberg, E.B., Liao, C.-H., and Projan, S.J. (1992) A staphylococcal multidrug resistance gene product is a member of a new protein family. Plasmid 27, 119-129
9. Sasatsu, M., Shima, K., Shibata, Y., and Kono, M. (1989) Nucleotide sequence of a gene that encodes resistance to ethidium bromide from a transferable plasmid in Staphylococcus aureus. Nucleic Acids Res. 17, 10103
10. Littlejohn, T.G., DiBerardino, D., Meserotti, L.J., Spiers, S.J., and Skurray, R.A. (1990) Structure and evolution of a family of genes encoding antiseptic and disinfectant resistance in Staphylococcus aureus. Gene 101, 59-66
11. Paulsen, I.T., Littlejohn, T.G., Radstrom, P., Sundstrom, L., Skold, O., Swedberg, G., and Skurray, R.A. (1993) The 3′ conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants. Antimicrob. Agents Chemother. 37, 761-768
12. + and is soluble in organic solvents. J. Biol. Chem. 270, 6856-6863
13. Ma, D., Cook, D.N., Alberti, M., Pon, N.G., Nikaido, H., and Hearst, J.E.J. (1993) Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J. Bacteriol. 175, 6299-6313
14. Ma, D., Cook, D.N., Alberti, M., Pon, N.G., Nikaido, H., and Hearst, J.E. (1995) Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol. Microbiol. 16, 45-55
15. Klein, J.R., Henrich, B., and Plapp, R. (1991) Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli. Mol. Gen. Genet. 230, 230-240
16. Poole, K., Krebes, K., McNally, C., and Neshat, S. (1993) Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J. Bacteriol. 175, 7363-7372
17. Li, X.Z., Livermore, D.M., and Nikaido, H. (1994) Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to β-lactam resistance. Antimicrob. Agents Chemother. 38, 1742-1752
18. Bolhuis, H., van Veen, H.W., Malenaar, D., Poolman, B., Driessen, A.J.M., and Konings, W.N. (1996) Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane. EMBO J. 15, 4239-4245
19. Ross, J.I., Eady, E.A., Cove, J.H., and Baumberg, S. (1995) Identification of a chromosomally encoded ABC-transport system with which the Staphylococcal erythromycin exporter MsrA may interact. Gene 153, 93-98
20. Burns, J.L., Rubens, C.E., Mendelman, P.M., and Smith, A.L. (1986) Cloning and expression in Escherichia coli of a gene encoding nonenzymatic chloramphenicol resistance from Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 29, 445-450
21. Bissonnette, L., Champetier, S., Buisson, J.P., and Roy, P.H. (1991) Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins. J. Bacteriol. 173, 4493-4502
22. Stokes, H.W. and Hall, R.M. (1991) Sequence analysis of the inducible chloramphenicol resistance determinant in the Tn1696 integron suggests regulation by translational attenuation. Plasmid 26, 10-19
23. Desomer, J., Vereecke, D., Crespi, M., and Van, M.M. (1992) The plasmid-encoded chloramphenicol-resistance protein of Rhodococcus fascians is homologous to the transmembrane tetracycline efflux proteins. Mol. Microbiol. 6, 2377-2385
24. Dittrich, W., Betzler, M., and Schrempf, H. (1991) An amplifiable and deletable chloramphenicol-resistance determinant of Streptomyces lividans 1326 encodes a putative transmembrane protein. Mol. Microbiol. 5, 2789-2797
25. Okamoto, S. and Suzuki, Y. (1965) Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R.' Nature 208, 1301-1303
26. Baughman, G.A. and Fahnestock, S.R. (1979) Chloramphenicol resistance mutation in Escherichia coli which maps in major ribosomal protein gene cluster. J. Bacteriol. 137, 1315-1323
27. Reeve, E.C. (1968) Genetic analysis of some mutations causing resistance to tetracycline in Escherichia coli K12. Genet. Res. 11, 303-309
28. Reeve, E.C. and Suttie, D.R. (1968) Chromosomal location of a mutation causing chloramphenicol resistance in Escherichia coli K 12. Genet. Res. 11, 97-104
29. Nilsen, I.W., Bakke, I., Vader, A., Olsvik, O., and El, G.M. (1996) Isolation of cmr, a novel Escherichia coli chloramphenicol resistance gene encoding a putative efflux pump. J. Bacteriol. 178, 3188-3193
30. Edger, R. and Bibi, E. (1997) MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition. J. Bacteriol 179, 2274-2280
31. + in thiomethylgalactoside transport by the melibiose transport system of Escherichia coli. J. Bacteriol. 134, 147-156
32. Imae, Y. (1968) Mitomycin C-sensitive mutant of Escherichia coli K-12. J. Bacteriol. 95, 1191-1192
33. Lennox, E.S. (1955) Transduction of linked genetic characters of host by bacteriophage P1. Virology 1, 190-206
34. Berns, K.I. and Thomas, C.A. (1965) Isolation of high molecular weight DNA from Haemophilus influenzae. J. Mol. Biol. 11, 476-490
35. Sanger, F., Nicklen, S., and Coulson, A.R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467
36. + antiporter of Vibrio parahaemolyticus. J. Biochem. 116, 1030-1038
37. Tanaka, S., Lerner, S.A., and Lin, E.C.C. (1967) Replacement of a phosphoenolpyruvate-dependent phosphotransferase by a nicotinamide adenine dinucleotide-linked dehydrogenase for the utilization of mannitol. J. Bacteriol. 93, 642-648
38. Bolhuis, H., Poelarends, G., van Veen, H.W., Poolman, B., Driessen, A.J.M., and Konings, W. (1995) The Lactococcal lmrP gene encodes a proton motive force-dependent drug transporter. J. Biol. Chem. 270, 26092-26098
39. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275
40. Kyte, J. and Doolittle, R.F. (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157, 105-132
41. Altschul, S.F., Gish, W., Miller, W., Myers, E.W., and Lipman, D.J. (1990) Basic local alignment search tool. J. Mol. Biol. 215, 403-410
42. Burland, V.G., Plunkett, G., Sofia, H.J., Daniels, D.L., and Plattner, F.R. (1995) Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 23, 2105-2119
43. Culham, D.E., Lasby, B., Marangoni, A.G., Milner, J.L., Steer, B.A., van Nues, R.W., and Wood, J.M. (1993) Isolation and sequencing of Escherichia coli gene proP reveals unusual structural features of the osmoregulatory proline/betaine transporter, ProP. J. Mol. Biol. 229, 268-276
44. Fujisaki, S., Ohnuma, S., Horiuchi, T., Takahashi, I., Tsukui, S., Nishimura, Y., Nishino, T., Kitabatake, M., and Inokuchi, H. (1996) Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification. Gene 175, 83-87