The effect of excitotoxic hippocampal lesions on simple and conditional discrimination learning in the rat

Behavioural Brain Research

Volumn 99, Issue 1, 1999, Pages 103-113

  Murray, T K ^a,c   Ridley, R M ^b  

^a Astra Arcus AB   (Sweden)

^b Department Experimental Psychology   (United Kingdom)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Conditional discrimination; Hippocampus; Learning; Rat; Reversal; Spatial discrimination; Y maze

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN INJURY; CONDITIONING; HIPPOCAMPUS; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL DISCRIMINATION; SPATIAL MEMORY; TASK PERFORMANCE;

ANIMALS; DISCRIMINATION (PSYCHOLOGY); DISCRIMINATION LEARNING; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; MALE; N-METHYLASPARTATE; PSYCHOMOTOR PERFORMANCE; RATS; REVERSAL LEARNING; SPACE PERCEPTION; VISUAL PERCEPTION;

EID: 0033557792     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(98)00077-1     Document Type: Article

References (25)

1. Davidson TL, McKernan MG, Jarrard LE. Hippocampal lesions do not impair negative patterning: a challenge to configural association learning. Behav Neurosci 1993;107:227-34.
2. Deacon RMJ, Rawlins JNP. Effects of aspiration lesions of hippocampus or overlying neocortex on concurrent and configural object discrimination in rats. Behav Brain Res 1996;77:165-74.
3. Eichenbaum H, Otto T, Cohen NJ. Two functional components of the hippocampal memory system. Behav Brain Sci 1994;17:449-518.
4. Jarrard LE. Selective hippocampal lesions and behavior: implications for current research and theorizing. In: Isaacson RL, Pribram KH, editors. The Hippocampus, 4. New York: Plenum Press, 1986.
5. Jarrard LE. On the role of the hippocampus in learning and memory in the rat. Behav Neural Biol 1993;60:9-26.
6. Kimble DP. The effect of bilateral hippocampal lesions in rats. J Comp Physiol Psychol 1963;56:273-83.
7. 3[H]glutamate binding sites in rat brain as determined by quantitiative antoradiography. J Neurosci 1985;5:2909-19.
8. Murray TK, Ridley RM. The effect of dizocilpine (MK801) on conditional discrimination learning in the rat. Behav Pharmacol 1997;8:383-8.
9. Murray TK, Ridley RM, Snape MF, Cross AJ. The effect of dizocilpine (MK-801) on spatial and visual discrimination tasks in the rat. Behav Pharmacol 1995;6:540-9.
10. Oliveira MGM, Bueno OFA, Pomarico AC, Gugliano EB. Strategies used by hippocampal- and caudate-putamen-lesioned rats in a learning task. Neurobiol Learn Mem 1997;68:32-41.
11. Olton DS, Becker JT, Handelmann GE. Hippocampus, space and memory. Behav Brain Sci 1979;2:313-22.
12. Olton DS, Papas BC. Spatial memory and hippocampal function. Neuropsychologia 1979;17:669-82.
13. Paxinos G, Watson C. The rat brain. Stereotaxic Coordinates. Australia: Academic Press, 1986.
14. Ridley RM, Baker HF. Evidence for a specific information processing deficit in monkeys with lesions of the septohippocampal system. Cortex 1997;33:167-76.
15. Ridley RM, Baker HF, Harder JA, Pearson C. Effects of lesions of different parts of the septo-hippocampal system in primates on learning and retention of information acquired before or after surgery. Brain Res Bull 1996;40:21-32.
16. Robinson GS, Crooks GB, Shinkman PG, Gallagher M. Behavioural effects of MK-801 mimic deficits associated with hippocampal damage. Psychobiology 1989;17:156-64.
17. Rudy JW, Sutherland RJ. The hippocampal formation is necessary for rats to learn and remember configural discriminations. Behav Brain Res 1989;34:97-109.
18. Samuels I. Hippocampal lesions in the rat: effects on spatial and visual habits. Physiol Behav 1972;8:1093-8.
19. Schenk F, Morris RGM. Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions. Exp Brain Res 1985;58:11-28.
20. Seldon NRW, Everitt BJ, Jarrard LE, Robbins TW. Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues. Neuroscience 1991;42:335-50.
21. Silveira JM, Kimble DP. Brightness discrimination and reversal in hippocampally-lesioned rats. Physiol Behav 1968;3:625-30.
22. Stevens R. Effet of amount of training on reversal learning in hippocampectomized rats. Physiol Psychol 1973;1:377-9.
23. Sutherland RJ, Rudy JW. Configural association theory: the role of the hippocampal formation in learning, memory, and amnesia. Psychobiology 1989;17:129-44.
24. Wible CG, Shiber JR, Olton DS. Hippocampus, fimbria-fornix, amygdala, and memory: object discrimination. Behav Neurosci 1992;106:751-61.
25. Winocur G. Effects of interference on discrimination learning and recall by rats with hippocampal lesions. Physiol Behav 1979;22:339-45.