The effect of dizocilpine (MK-801) on conditional discrimination learning in the rat

Behavioural Pharmacology

Volumn 8, Issue 5, 1997, Pages 383-388

  Murray, T K ^a   Ridley, R M ^b  

^a Astra Arcus AB   (Sweden)

^b Department Experimental Psychology   (United Kingdom)

Author keywords

Conditional discrimination; Dizocilpine (MK 801); Learning; NMDA receptors; Rat; Reversal; Y maze

Indexed keywords

AMINO ACID RECEPTOR BLOCKING AGENT; DIZOCILPINE MALEATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL; ARTICLE; CONDITIONING; DISCRIMINATION LEARNING; DRUG ANTAGONISM; DRUG EFFECT; MALE; MAZE TEST; PSYCHOMOTOR PERFORMANCE; RAT;

ANIMALS; CONDITIONING (PSYCHOLOGY); DISCRIMINATION LEARNING; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MAZE LEARNING; PSYCHOMOTOR PERFORMANCE; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0031240557     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-199710000-00002     Document Type: Article

References (17)

1. Caramanos Z and Shapiro ML (1994) Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: memory impairments depend on familiarity with the environment, drug dose, and training duration. Behavioural Neuroscience, 108, 30-43.
2. Danysz W, Wroblewski JT and Costa E (1988) Learning impairment in rats by N-methyl-D-aspartate receptor antagonists. Neuropharmacology, 27, 653-656.
3. Eichenbaum H, Otto T and Cohen NJ (1993) Two functional components of the hippocampal memory system. Behavioral and Brain Sciences, 17, 449-500.
4. Francis PT, Pangalos MN and Bowen DM (1992) Animal and drug modelling for Alzheimer synaptic pathology. Progress in Neurobiology, 39, 517-545.
5. Kimble DP (1963) The effect of bilateral hippocampal lesions in rats. Journal of Comparative and Physiological Psychology, 56, 273-283.
6. Monaghan DT and Cotman CW (1985) Distribution of NMDA-sensitive, L-3H-glutamate binding sites in rat brain as determined by quantitative autoradiography. Journal of Neuroscience, 5, 2909-2919.
7. Morris RGM, Anderson E, Lynch GS and Baudry M (1986) Selective impairment of spatial learning and blockade of long-term potentiation by N-methyl-D-aspartate receptor antagonist AP5. Nature, 319, 774-776.
8. Murray TK, Ridley RM, Snape MF and Cross AJ (1995) The effect of dizocilpine (MK-801) on spatial and visual discrimination tasks in the rat. Behavioural Pharmacology, 6, 540-549.
9. Ottersen OP (1991) Excitatory amino acid neurotransmitters: anatomical systems. In: Excitatory Amino Acid Antagonists (Ed BS Meldrum), pp. 14-38. Blackwell Scientific, Oxford.
10. Ridley RM and Baker HF (1997) Evidence for a specific information processing deficit in monkeys with lesions of the septo-hippocampal system. Cortex, 33, 167-176.
11. Ridley RM, Baker HF, Harder JA and Pearson C (1996) Effects of lesions of different parts of the septo-hippocampal system in primates on learning and retention of information acquired before or after surgery. Brain Research Bulletin, 40, 21-32.
12. Robinson GS, Crooks GB, Shinkman PG and Gallagher M (1989) Behavioural effects of MK-801 mimic deficits associated with hippocampal damage. Psychobiology, 17, 156-164.
13. Shapiro ML and Caramanos Z (1990) NMDA antagonist MK-801 impairs acquisition but not performance of spatial working and reference memory. Psychobiology, 18, 231-243.
14. Shapiro ML and O'Connor C (1992) N-methyl-D-aspartate receptor antagonist MK-801 and spatial memory representation: working memory is impaired in an unfamiliar environment but not in a familiar environment. Behavioural Neuroscience, 106, 604-612.
15. Tan S, Kirk RC, Abraham WC and McNaughton N (1989) Effects of the NMDA antagonists CPP and MK-801 on delayed conditional discrimination. Psychopharmacology, 98, 556-560.
16. Tricklebank MD, Singh L, Oles RJ, Preston C and Iversen SD (1989) The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor. European Journal of Pharmacology, 167, 127-135.
17. Wong EHF, Kemp JA, Priestly T, Knight AR, Woodruff GN and Iversen LL (1986) The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proceedings of the National Academy of Sciences of the USA 83, 7104-7108.