Design and synthesis of silyl ether-based linker for solid-phase synthesis of glycopeptides

Tetrahedron Letters

Volumn 40, Issue 3, 1999, Pages 515-518

  Nakamura, Kazuhiko ^a   Hanai, Noriyasu ^a   Kanno, Masayuki ^a   Kobayashi, Aki ^a   Ohnishi, Yuki ^b   Ito, Yukishige ^b   Nakahara, Yoshiaki ^a,b  

^a TOKAI UNIVERSITY   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROPHENOL; 9 FLUORENYLMETHYL CHLOROFORMATE; ALCOHOL DERIVATIVE; FLUORIDE; GLYCINE; GLYCOPEPTIDE; RESIN; SILANE DERIVATIVE; SUCCINIC ACID DERIVATIVE;

ARTICLE; CHEMICAL REACTION; HYDROLYSIS; PEPTIDE SYNTHESIS; POLYMERIZATION; SOLID STATE;

EID: 0033555231     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02390-9     Document Type: Article

References (19)

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19. Selected physical data are given below, compound 4: mp 114.5-117 °C, δH: 7.96 (d, 2H), 7.23 (d, 2H), 1.31 (s, 6H), 0.11 (s, 6H). compound 9: [α]D+2.6°(c 1.0), δH: 7.74-7.13 (m, 12H), 5.87 (m, 1H), 5.56 (d, 1H), 5.31 (brd, 1H), 5.23 (brd, 1H), 4.64 (d, 2H), 4.40 (m, 1H), 4.39, 4.31, and 4.24 (3brt, 3H), 3.95 (dd, 1H), 3.69 (dd, 1H), 2.63 and 2.50 (2m, 4H), 1.29 and 1.30 (2s, 6H), -0.50 and -0.59 (2s, 6H). compound 13: [α]D+83.0° (c 1.0), δH: 7.78 (d, 2H), 7.64 (d, 2H), 7.43-7.32 (m, 4H), 7.02 (d, 1H), 6.75 (d, 1H), 5.92 (m, 1H), 5.84 (d, 1H), 5.37 (brd, 1H), 5.36 (brd, 2H). 5.29 (dd, 1H), 5.21 (dd, 1H), 5.17 (d, 1H), 5.10 (dd, 1H), 4.99 (d, 1H), 4.69 (brd, 2H), 2.16 (s, 3H), 2.15 (s, 3H), 2.04 (s, 3H), 2.00 (s, 9H), 1.99 (s, 6H), 1.28 (d, 3H), 1.24 (d, 3H).