Effects of β3-integrin blockade (c7E3) on the response to angioplasty and intra-arterial stenting in atherosclerotic nonhuman primates

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 11, 1998, Pages 1730-1737

  Deitch, Jonathan S ^a   Williams, J Koudy ^a   Adams, Michael R ^a   Fly, Christopher A ^a   Herrington, David M ^a   Jordan, Robert E ^b   Nakada, Marian T ^b   Jakubowski, Joseph A ^c   Geary, Randolph L ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b CENTOCOR INC   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Atherosclerosis; Cynomolgus monkeys; Restenosis; Stents; 3 integrins

Indexed keywords

ABCIXIMAB; INTEGRIN; ANTITHROMBOCYTIC AGENT; IMMUNOGLOBULIN F(AB) FRAGMENT; LIPID; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL DIAMETER; CORONARY ARTERY ATHEROSCLEROSIS; DRUG EFFICACY; HEART CATHETERIZATION; ILIAC ARTERY; MALE; MONKEY; NONHUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RECURRENCE RISK; RESTENOSIS; STENT; SUBCLAVIAN ARTERY; THROMBOCYTE AGGREGATION; THROMBOGENESIS; TRANSLUMINAL CORONARY ANGIOPLASTY; ANIMAL; ARTERIOSCLEROSIS; ARTERY; BLOOD; BLOOD CLOTTING; BLOOD EXAMINATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; HYPERPLASIA; MACACA; MULTIMODALITY CANCER THERAPY; TREATMENT OUTCOME;

ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; ANIMALS; ANTIBODIES, MONOCLONAL; ARTERIES; ARTERIOSCLEROSIS; BLOOD COAGULATION; COMBINED MODALITY THERAPY; DRUG EVALUATION, PRECLINICAL; HEMATOLOGIC TESTS; HYPERPLASIA; IMMUNOGLOBULIN FAB FRAGMENTS; INTEGRINS; LIPIDS; MACACA FASCICULARIS; MALE; PLATELET AGGREGATION INHIBITORS; STENTS; TREATMENT OUTCOME;

EID: 0031596249     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.11.1730     Document Type: Article

References (12)

1. Topol EJ, Califf RM, Weisman HF, Ellis SG, Tcheng JE, Worley S, Ivanhoe R, George BS, Fintel D, Weston M, Sigmon K, Anderson KM, Lee KL, Willerson JT. Randomized trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months. Lancet. 1994;343:881-886.
2. Lefkovits J, Ivanhoe RJ, Califf RM, Bergelson BA, Anderson KM, Stoner GL, Weisman HF, Topol EJ. Effects of platelet glycoprotein IIb/IIIa receptor blockade by a chimeric monoclonal antibody (abciximab) on acute and six-month outcomes after percutaneous transluminal coronary angioplasty for acute myocardial infarction. Am J Cardiol. 1996;77:1045-1051.
3. The EPILOG Investigators. Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization. N Engl J Med. 1997;336:1689-1696.
4. Nakada MT, Jordan RE, Knight DM. Abciximab (ReoPro, chimeric 7E3 Fab) cross-specificity with αvβ3 integrin receptors: a potential mechanism for the prevention of restenosis. J Am Coll Cardiol. 1997;28:243A. Abstract.
5. Jones JI, Prevette T, Gockerman A, Clemmons DR. Ligand occupancy of the αvβ3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor I. Proc Natl Acad Sci USA. 1996;93:2482-2487.
6. Leavesley DI, Schwartz MA, Rosenfeld M, Cheresh DA. Integrin β1-and β3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol. 1993;121:163-170.
7. 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro. Circ Res. 1995;77:665-672.
8. Anilkumar N, Bhattacharya AK, Manogaran PS, Pande G. Modulation of α5β1 and αVβ3 integrins on the cell surface during mitosis. J Cell Biochem. 1996;61:338-349.
9. 3 for angiogenesis. Science. 1994;264:569-571.
10. Stromblad S, Becker JC, Yebra M, Brooks PC, Cheresh DA. Suppression of p53 activity and p21WAFI/CIPI expression by vascular cell integrin αVβ3 during angiogenesis. J Clin Invest. 1996;98:426-433.
11. Katagiri Y, Hiroyama T, Akamatsu N, Suzuki H, Yamazaki H, Tanoue K. Involvement of αvβ3 integrin in mediating fibrin gel retraction. J Biol Chem. 1995;270:1785-1790.
12. Henke CA. Intra-alveolar fibrosis: αvβ3 integrin and chondroitin sulfate proteoglycan mediate endothelial cell adhesion, migration, and invasion into the fibrin provisional matrix. Chest. 1994;15:121S-122S.