Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]- xanthine

Journal of Medicinal Chemistry

Volumn 40, Issue 12, 1997, Pages 1773-1778

  Pfister, Jürg R ^a   Belardinelli, Luiz ^b   Lee, Gavin ^a   Lum, Robert T ^g   Milner, Peter ^c   Stanley, William C ^d   Linden, Joel ^e   Baker, Stephen P ^b   Schreiner, George ^f  

^a ROCHE BIOSCIENCE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c ARYx Therapeutics   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e UNIVERSITY OF VIRGINIA   (United States)

^f SCIOS INC   (United States)

^g CV THERAPEUTICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 (2 NOR 1 ADAMANTYL) 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYLTHEOPHYLLINE; 8 DICYCLOPROPYLMETHYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; NAXIFYLLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIURESIS; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENANTIOMER; GUINEA PIG; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; POTASSIUM EXCRETION; RACEMIC MIXTURE; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; SODIUM EXCRETION; X RAY CRYSTALLOGRAPHY;

ANIMALS; DIURESIS; GUINEA PIGS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; RECEPTORS, PURINERGIC P1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHINES;

EID: 0030954062     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970013w     Document Type: Article

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