B-Cell epitopes in hypervariable region 1 of hepatitis C virus obtained from patients with chronic persistent hepatitis

Journal of Medical Virology

Volumn 50, Issue 1, 1996, Pages 35-41

  Nakamoto, Yasunari ^a   Kaneko, Shuichi ^a   Ohno, Hideki ^a   Honda, Masao ^a   Unoura, Masashi ^a   Murakami, Seishi ^a   Kobayashi, Kenichi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Chronic hepatitis C; Interferon; Synthetic peptide

Indexed keywords

ENVELOPE PROTEIN; INTERFERON; SYNTHETIC PEPTIDE;

ADULT; ARTICLE; B LYMPHOCYTE; CASE REPORT; CHRONIC ACTIVE HEPATITIS; DRUG RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FEMALE; HEPATITIS C; HUMAN; MALE;

ADULT; AMINO ACID SEQUENCE; CHRONIC DISEASE; EPITOPES, B-LYMPHOCYTE; FEMALE; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIGENS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA;

HEPATITIS C VIRUS;

EID: 0029972341     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199609)50:1<35::AID-JMV8>3.0.CO;2-U     Document Type: Article

References (19)

1. Chien DY, Choo Q-L, Tabrizi A, Kuo C, McFarland J, Berger K, Lee C, Shuster JR, Nguyen T, Moyer DL, Tong J, Furuta S, Omata M, Tegtmeier G, Alter H, Schiff E, Jeffers L, Houghton M, Kuo G (1992): Diagnosis of hepatitis C virus (HCV) infection using an immunodominant chimeric polyprotein to capture circulating antibodies: Reevaluation of the role of HCV in liver disease. Proceedings of the National Academy of Sciences of the United States of America 89:10011-10015.
2. Choo Q-L, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M (1989): Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
3. Davis GL, Lau JY-N, Urdea MS, Neuwald PD, Wilber JC, Lindsay K, Perrillo RP, Albrecht J (1994): Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: Definition of optimal conditions for specimen collection and clinical application in interferon-treated patients. Hepatology 19:1337-1341.
4. Dienstag JL (1983): Non-A, non-B hepatitis: Recognition, epidemiology and clinical features. Gastroenterology 85:439.
5. Geysen HM, Meloen RH, Barteling SJ (1984): Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proceedings of the National Academy of Sciences of The United States of America 81:3998-4002.
6. Hijikata M, Kato N, Ootsuyama Y, Nakagawa M, Ohkoshi S, Shimotohno K (1991): Hypervariable regions in the putative glycoprotein of hepatitis C virus. Biochemical and Biophysical Research Communications 175:220-228.
7. Kaneko S, Miller RH, Feinstone SM, Unoura M, Kobayashi K, Hattori N, Purcell RH (1989): Detection of serum hepatitis B virus DNA in patients with chronic hepatitis using the polymerase chain reaction assay. Proceedings of the National Academy of Sciences of The United States of America 86:312-316.
8. Kato N, Ootsuyama Y, Ohkoshi S, Nakazawa T, Sekiya H, Hijikata M, Shimotohno K (1992): Characterization of hypervariable regions in the putative envelope protein of hepatitis C virus. Biochemical and Biophysical Research Communications 189:119-127.
9. Kato N, Ootsuyama Y, Sekiya H, Ohkoshi S, Nakazawa T, Hijikata M, Shimotohno K (1994): Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C viras infection. Journal of Virology 68:4776-4784.
10. Kuo G, Choo Q-L, Alter HJ, Gitnick GL, Redeker AG, Purcell RH, Miyamura T, Dienstag JL, Alter MJ, Stevens CE, Tegtmeier GE, Bonino F, Colombo M, Lee W-S, Kuo C, Berger K, Shuster JR, Overby LR, Bradley DW, Houghton M (1989): An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244:362-364.
11. Nakamoto Y, Kaneko S, Honda M, Unoura M, Cheong J, Harada A, Matsushima K, Kobayashi K, Murakami S (1994): Detection of the putative E2 protein of hepatitis C virus in human liver. Journal of Medical Virology 42:374-379.
12. Okamoto H, Kojima M, Okada S-I, Yoshizawa H, Iizuka H, Tanaka T, Muchmore EE, Peterson DA, Ito Y, Mishiro S (1992a): Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: Variability and stability. Virology 190:894-899.
13. Okamoto H, Tsuda F, Machida A, Munekata E, Akahane Y, Sugai Y, Mashiko K, Mitsui T, Tanaka T, Miyakawa Y, Mayumi M (1992b): Antibodies against synthetic oligopeptides deduced from the putative core gene for the diagnosis of hepatitis C virus infection. Hepatology 15:180-186.
14. Reichard O, Foberg U, Fryden A, Mattsson L, Norkrans G, Sonnerborg A, Wejstal R, Yun Z-B, Weiland O (1994): High sustained response rate and clearance of viremia in chronic hepatitis C after treatment with interferon-a2b for 60 weeks. Hepatology 19:280-285.
15. Shindo M, Di Bisceglie A, Cheung L, Wai-Kuo Shih J, Cristiano K, Feinstone S, Hoofnagle J (1991): Decrease in serum hepatitis C viral RNA during alpha-interferon therapy for chronic hepatitis C. Annals of Internal Medicine 115:700-704.
16. Taniguchi S, Okamoto H, Sakamoto M, Kojima M, Tsuda F, Tanaka T, Munekata E, Muchmore EE, Peterson DA, Mishiro S (1993): A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: Implication for an escape from antibody. Virology 195:297-301.
17. Tine F, Magrin S, Craxi A, Pagliaro L (1991): Interferon for non-A, non-B chronic hepatitis. A meta-analysis of randomised clinical trials. Journal of Hepatology 13:192-199.
18. Weiner AJ, Brauer MJ, Rosenblatt J, Richman KH, Tung J, Crawford K, Bonino F, Saracco G, Choo Q-L, Houghton M, Han JH (1991): Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology 180:842-848.
19. Weiner AJ, Geysen HM, Christopherson C, Hall JE, Mason TJ, Saracco G, Bonino F, Crawford K, Marion CD, Crawford KA, Brunette M, Barr PJ, Miyamura T, McHutchinson J, Houghton M (1992): Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: Potential role in chronic HCV infections. Proceedings of the National Academy of Sciences of The United States of America. 89:3468-3472.