Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells and monocytes derived from CD34+ cells transduced with an intracellular antibody directed against human immunodeficiency virus type 1 Tat

Human Gene Therapy

Volumn 10, Issue 15, 1999, Pages 2505-2514

  Poznansky, Mark C ^a   La Vecchio, Joyce ^b   Silva Arietta, Sandra ^a   Porter Brooks, Julie ^c   Brody, Kate ^a   Olszak, Ivona T ^a   Adams, Gregor B ^a   Ramstedt, Urban ^c   Marasco, Wayne A ^b   Scadden, David T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Virus Research Institute Inc Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD4 ANTIGEN; TRANSACTIVATOR PROTEIN;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ARTICLE; CELL DIFFERENTIATION; CYTOTOXIC T LYMPHOCYTE; GENE THERAPY; GENETIC TRANSDUCTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MARKER GENE; MONOCYTE; UMBILICAL CORD BLOOD; VIRUS REPLICATION;

ADULT; ANTIGENS, CD34; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CELL LINEAGE; DNA PRIMERS; GENE PRODUCTS, TAT; HIV-1; HUMANS; IMMUNOPHENOTYPING; MONOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSDUCTION, GENETIC; TRANSGENES; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0033544017     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950016843     Document Type: Article

References (30)

1. BELMONT, J.W., MACGREGOR, G.R., WAGNER-SMITH, K., FLETCHER, F.A., MOORE, K.A., HAWKINS, D., VILLALON, D., CHANG, S.M.W., and CASKEY, C.T. (1988). Expression of human adenosine deaminase in murine hematopoietic cells. Mol. Cell. Biol. 8, 5116.
2. BRENNER, M.K., CUNNINGHAM, J.M., SORRENTINO, B.P., and HESLOP, H.E. (1995). Gene transfer into human hematopoietic progenitor cells. Br. Med. Bull. 51, 167-191.
3. CARTER, R.F., ABRAMS-OGG, A.G., DICK, J.E., KRUTH, S.A., VALLI, W.E., KAMELREID, S., and DUBE, I.D. (1992). Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors. Blood 79, 356.
4. DROPULIC, B., and JEANG, K.-T. (1994). Gene therapy for human immunodeficiency virus infection: Genetic antiviral strategies and targets for intervention. Hum. Gene Ther. 5, 927-939.
5. DUNBAR, C.E. (1996). Gene transfer to hematopoietic stem cells: Implications for gene therapy of human disease. Annu. Rev. Med. 47, 11-20.
6. FREEDMAN, A.R., ZHU, H., LEVINE, J.D., KALAMS, S., and SCADDEN, D.T. (1995). Generation of human T-lymphocytes from bone marrow CD34+ cells in vitro. Nature Med. 2, 46-51.
7. HAUBRICH, R., MCCUTCHAN, J.A., HOLDREDGE, R., HEINER, L., MERRITT, J., MERCHANT, E. (1995). An open label, phase I/II clinical trial to evaluate the safety and biological activity of HIV-IT (V) (HIV-1IIIBenv/rev retroviral vector) in HIV-1-infected subjects. Hum. Gene Ther. 6, 941-955.
8. KARLSSON, S. (1991). Treatment of genetic defects in hematopoietic cell function by gene transfer. Blood 78, 2481-2492.
9. KOTANI, H., NEWTON, P.B., ZHANG, S., CHIANG, Y.L., OTTO, E., WEAVER, L., BLAESE, M., FRENCH ANDERSON, W., and MCGARRITY, G.J. (1994). Improved methods of retroviral vector transduction and production for gene therapy. Hum. Gene Ther. 5, 19-28.
10. + donors: Prelude to a ribozyme gene therapy trial. Gene Ther. 3(7), 599-606.
11. + cells purified from peripheral blood of breast cancer patients primed with chemotherapy and GM-CSF. Hum. Gene Ther. 5, 203-208.
12. MALIM, M.H., FREIMUTH, J., LIU, J., BOYLE, T.J., LYERLY, H.K., and CULLEN, B.R. (1992). Stable expression of transdominant Rev protein in human T-cells inhibits HIV replication. J. Exp. Med. 176, 1197-1201.
13. MARASCO, W.A., HASELTINE, W.A., and CHEN, S.-Y. (1993). Design, intracellular expression and activity of a human anti-human immunodeficiency virus type 1 gp120 single chain antibody. Proc. Natl. Acad. Sci. U.S.A. 90, 7889-7893.
14. MARASCO, W.A., CHEN, S.Y., RICHARDSON, J., RAMSTEDT, U., and JONES, S. (1998). Clinical protocol: Intracellular antibody against HIV-1 envelope protein for AIDS gene therapy. Hum. Gene Ther. 9, 1627-1642.
15. MHASHILKAR, A.M., BAGLEY, J., CHEN, S.Y., SZILVAY, A.M., HELLAND, D.G., and MARASCO, W.A. (1995). Inhibition of HIV-1 Tat-mediated LTR transactivation and HIV-1 infection by anti-Tat single chain intrabodies. EMBO J. 14, 1542-1551.
16. MHASHILKAR, A.M., LA VECCHIO, J., EDEHARDT, B., BROOKS, J., BOISOT, S., DOVE, J.H., PUMPHREY, C., LI, X., WEISSMAHR, R.N., RING, D.B., RAMSTEDT, U., and MARASCO, W.A. (1999). Inhibition of human immunodeficiency virus type 1 replication in vitro in acutely and persistently infected human CD4+ mononuclear cells expressing murine and humanized anti-HTV-1 Tat sFv intrabodies. Hum. Gene Ther. 10, 1453-1467.
17. MILLER, A.D. (1992). Retroviral vectors. Curr. Top. Microbiol. Immunol. 158, 1-24.
18. MORGAN, R.A. and WALKER, R. (1996). Gene therapy for AIDS using retroviral mediated gene transfer to deliver HIV-1 antisense TAR and transdominant Rev protein genes to syngeneic lymphocytes in HIV-1 infected identical twins. Hum. Gene Ther. 7, 1281-1306.
19. MORITZ, T., KELLER, D.C., and WILLIAMS, D.A. (1993). Human cord blood cells as targets for gene transfer: Potential use in gene therapies of severe combined immunodeficiency disease. J. Exp. Med. 178, 529-536.
20. NABEL, G.J., FOX, B.A., POST, L., THOMPSON, C.B., and WOFFENDIN, C. (1994). Clinical protocol: A molecular genetic intervention for AIDS - effect of a transdominant negative form of rev. Hum. Gene Ther. 5, 79-92.
21. POZNANSKY, M.C., WALKER, B., HASELTINE, W.A., SODROSKI, J., and LANGHOFF, E. (1991). A rapid method for quantitating the frequency of peripheral blood cells containing HIV-1 DNA. J. Acquir. Immune Defic. Syndr. 4, 368-373.
22. POZNANSKY, M.C., ADAMS, G.B., and MCCLURE, M. (1998a). Gene therapy for the treatment of HTV-1 infection. In Biotechnology, Vol. 5. (Wiley-VCH, Verlag, Gmbh, Germany).
23. POZNANSKY, M.C., FOXALL, R., MHASHILKAR, A., COKER, R., JONES, S., RAMSTEDT, U., and MARASCO, W.A. (1998b). Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T-cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp 120 or Tat. Hum. Gene Ther. 9, 487-496.
24. RANGA, U., WOFFENDIN, C., VERMA, S., XU, L., JUNE, C.H., BISHOP, D.K., and NABEL, G. (1998). Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals. Proc. Natl. Acad. Sci. U.S.A. 95(3), 1201-1206.
25. ROSENZWEIG, M., MARKS, D.F., ZHU, H., HEMPEL, D., MANSFEILD, K.G., SEHGAL, P.K., KALAMS, S., SCADDEN, D.T., and JOHNSON, R.P. (1996). In vitro T-lymphopoiesis of human and rhesus CD34+ progenitor cells. Blood 87, 4040-4048.
26. ROSENZWEIG, M., MARKS, D.F., HEMPEL, D., LISZIEWICZ, X., and JOHNSON, R.P. (1997). Transduction of CD34+ hematopoietic progenitor cells with an anti-tat gene protects T-cell and macrophage progeny from AIDS virus infection. J. Virol. 71, 2749-2746.
27. SHAUNAK, S., ALBRIGHT, R.E., KLOTMAN, M.E., HENRY, S.C., BARTLETT, J.A., and HAMILTON, J.D. (1990). Amplification of HIV-1 provirus from cerebrospinal fluid and its correlation with neurologic disease. J. Infect. Dis. 161, 1068-1072.
28. YAMADA, O., YU, M., YEE, J.-K., KRAUS, G., LOONEY, D., and WONG-STAAL, F. (1994). Intracellular immunization of human T-cells with a hairpin ribozyme against human immunodeficiency virus type 1. Gene Ther. 1, 38-45.
29. YU, M., PEOSCHLA, E., and WONG-STAAL, F. (1994). Progress towards gene therapy for HIV infection. Gene Ther. 1, 13-26.
30. YU, M., LEAVITT, M.C., MARUYAMA, M., YAMADA, O., YOUNG, D., HO, A.D., and WONG-STAAL, F. (1995). Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. U.S.A. 92, 699-703.