Ex vivo transduction and expansion of CD4+ lymphocytes from HIV+ donors: Prelude to a ribozyme gene therapy trial

Gene Therapy

Volumn 3, Issue 7, 1996, Pages 599-606

  Leavitt, M C ^a,b   Yu, M ^a,b   Wong Staal, F ^a   Looney, D J ^a,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Immusol Inc   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Catalytic RNA; Gene therapy; Gene transfer; Genetic vectors; HIV 1; T lymphocyte subsets

Indexed keywords

CD4 ANTIGEN; NEVIRAPINE; RIBOZYME;

ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE; NONHUMAN; PHASE 1 CLINICAL TRIAL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS REPLICATION;

ANIMALS; ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; CELLS, CULTURED; CLINICAL TRIALS, PHASE I; GENE THERAPY; GENETIC VECTORS; HIV CORE PROTEIN P24; HIV SEROPOSITIVITY; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; NEVIRAPINE; PYRIDINES; RETROVIRIDAE; RNA, CATALYTIC; TRANSFECTION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MURINAE;

EID: 0029781202     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Piatak M et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 1993; 259: 1749-1754.
2. Ho DD et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995; 373: 123-126.
3. Wei X et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995; 373: 117-122.
4. Coffin JM. HIV population dynamics in vivo: implications for generic variation, pathogenesis and therapy. Science 1994; 267: 483-489.
5. Johnston MI, Hoth DF. Present status and future prospects for HIV therapies. Science 1993; 260: 1286-1293.
6. Yu M el al. A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1993; 90: 6340-6344.
7. Yamada O et al. Activity and cleavage site specificity of an anti-HIV-1 hairpin ribozyme in human T cells. Virology 1994; 205: 121-126
8. Larder BA, Kemp SD, Harrigan PR Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy. Science 1995; 269: 696-699.
9. Yamada O et al. Intracellular immunization of human T cells with a hairpin ribozyme against human immunodeficiency virus type 1. Gene Therapy 1994; 1: 38-45.
10. Leavitt MC et al. Transfer of an anti-HIV ribozyme gene into primary human lymphocytes. Hum Gene Ther 1994; 5: 1115-1120.
11. Yu M et at. Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1995; 92: 699-703.
12. Yu M, Poeschla E, Wong-Staal F. Progress towards gene therapy for HIV infection. Gene Therapy 1994; 1: 13-26.
13. - human T cell subsets derived from tumor-infiltrating lymphocytes and peripheral blood mononuclear cells. Cancer Immunol Immunother 1991; 32: 342-352.
14. Moran PA et al. Regulation of HIV production by mononuclear cells from HIV-infected donors: I. Lack of correlation between HIV-1 production and T cell activation. AIDS Res Hum Retroviruses 1993; 9: 455-464.
15. Plata F et al. AIDS virus specific cytotoxic T lymphocytes in lung disorders. Nature 1987; 328: 348-351.
16. Walker BD et al. HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature 1987; 328: 345-348.
17. Spence RA, Kati WM, Anderson KS, Johnson KA. Mechanism of inhibition of HTV-1 reverse transcriptase by nonnucleoside inhibitors. Science 1995; 267: 988-993.
18. Ashorn P et al. Elimination of infection of human immunodeficiency virus from human T cell cultures by synergistic action of CD4-pseudomonas exotoxin and reverse transcriptase inhibitors. Proc Natl Acad Sci USA 1990; 87: 8889-8893.
19. Riddell SR et al. T cell mediated rejection of gene-modified HIV specific cytotoxic T lymphocytes in HIV-infected patients. Nat Med 1996; 2: 216-223
20. + selected autologous peripheral blood cells transduced with a human ADA gene. Amendment to clinical research project, Project 90-C-195, January 10, 1992. Hum Gene Ther, 1993; 4: 521-527.
21. Yu M et al. In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1. Virology 1995; 206-381-386.