Structural basis of integrin-mediated signal transduction

Matrix Biology

Volumn 16, Issue 4, 1997, Pages 143-151

  Takada, Yoshikazu ^a   Kamata, Tetsuji ^a   Irie, Atsushi ^a   Puzon McLaughlin, Wilma ^a   Zhang, Xi Ping ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Integrin; Ligand binding; Signal transduction

Indexed keywords

CATION; EPITOPE; INTEGRIN; LIGAND; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; BINDING AFFINITY; BINDING SITE; CELL ADHESION; CELL INTERACTION; CONFORMATIONAL TRANSITION; EXTRACELLULAR MATRIX; GENETIC CONSERVATION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

EID: 0031259184     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0945-053X(97)90002-0     Document Type: Short Survey

References (61)

1. Bajt M., Loftus J. Mutation of a ligand binding domain of β3 integrin. Integral role of oxygenated residues in αIIbβ3 (GPIIb-IIIa) receptor function. J. Biol. Chem. 269:1994;20913-20919.
2. Bazzoni G., Shih D.T., Buck C.A., Hemler M.E. Monoclonal antibody 9EG7 defines a novel β1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J. Biol. Chem. 270:1995;25570-25577.
3. Charo I.F., Nannizzi L., Phillips D.R., Hsu M.A., Scarborough R.M. Inhibition of fibrinogen binding to GP IIb-IIIa by a GP IIIa peptide. J. Biol. Chem. 266:1991;1415-1421.
4. Cook J., Trybulec M., Lasz E., Khan S., Niewiarowski S. Binding of glycoprotein IIIa-derived peptide 217-231 to fibrinogen and von Willebrand factors and its inhibition by platelet glycoprotein IIb/IIIa complex. Biochim. Biophys. A. 1119:1992;312-321.
5. D'Souza S., Ginsberg M.H., Burke T.A., Lam S.C.-T., Plow E.F. Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science. 242:1988;91-93.
6. D'Souza S., Ginsberg M.H., Burke T.A., Plow E.F. The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its α subunit. J. Biol. Chem. 265:1990;3440-3446.
7. D'Souza S., Ginsberg M.H., Matsueda G.R., Plow E.F. A discrete sequence in a platelet integrin is involved in ligand recognition. Nature. 350:1991;66.
8. D'Souza S.E., Haas T.A., Piotrowicz R.S., Byers-Ward V., McGrath E., et al. Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: cation displacement from this site is implicated in ligand binding. Cell. 79:1994;659-667.
9. Diamond M.S., Garcia-Aguilar J., Bickford J.K., Corbi A.L., Springer T.A. The I-domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands. J. Cell Biol. 120:1993;1031-1043.
10. Dickenson S.K., Walsh J.J., Santoro S.A. Contribution of the I and EF hand domains to the divalent cation-dependent collagen binding activity of the α2β1 integrin. J. Biol. Chem. 272:1997;7661-7668.
11. Du X., Gu M., Weisel J., Nagaswami C., Bennett J., et al. Long range propagation of conformational changes in integrin αIIbβ3. J. Biol. Chem. 268:1993;23087-23092.
12. Goodman T., Bajt M. Identifying the putative metal ion-dependent adhesion site in the β2 (CD18) subunit required for aLb2 and aMb2 ligand interactions. J. Biol. Chem. 271:1996;23729-23736.
13. Hemler M.E. VLA proteins in the integrin family:structures, functions, and their role on leukocytes. Ann. Rev. Immunol. 8:1990;365-400.
14. Honda S., Tomiyama Y., Pelletier A., Annis D., Honda Y., et al. Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin β3 subunit. J. Biol. Chem. 270:1995;11947-11954.
15. Huang X., Chen A., Agrez M., Sheppard D. A point mutation in the integrin beta 6 subunit abolishes both αvβ6 binding to fibronectin and receptor localization to focal contacts. Am. J. Resp. Cell Mol. Biol. 13:1995;245-251.
16. Huizinga E.G., van der Plas R.M., Sixima J.J., Kroon J., Gros P. Crystal structure of the A3 domain of human von Willebrand factor. Thromb. Haemost. 1997;374. (abstract).
17. Hynes R.O. Integrins: versatility, modulation and signaling in cell adhesion. Cell. 69:1992;11-25.
18. Irie A., Kamata T., Puzon-McLaughlin W., Takada Y. Critical amino acid residues for ligand binding are clustered in a predicted β-turn of the third amino-terminal repeat in the integrin α4 and α5 subunits. EMBO J. 14:1995;5542-5549.
19. Irie A., Kamata T., Takada Y. Multiple loop structures critical for ligand binding of the integrin α4 subunit in the upper face of the β-propeller model. Proc. Natl. Acad. Sci. U.S.A. 94:1997;7198-7203.
20. Kamata T., Irie A., Takada Y. Critical residues of the αIIb subunit of integrin αIIβ3 (GPIIb-IIIa) for binding to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2 and LJ-CP3). J. Biol. Chem. 271:1996;18610-18615.
21. Kamata T., Puzon W., Takada Y. Identification of putative ligand binding sites within I-domain of integrin α2β1 (VLA-2, CD49b/CD29). J. Biol. Chem. 269:1994;9659-9663.
22. Kamata T., Puzon W., Takada Y. Identification of putative ligand binding sites of the integrin α4β1 (VLA-4, CD49d/CD29). Biochem. J. 305:1995;945-951.
23. Kamata T., Takada Y. Direct binding of collagen to the I-domain of integrin α2β1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner. J. Biol. Chem. 269:1994;26006-26010.
24. Kamata T., Wright R., Takada Y. Critical Thr and Asp residues within the I-domains of β2 integrins for interactions with ICAM-1 and C3bi. J. Biol. Chem. 270:1995;12531-12535.
25. Kern A., Briesewitz R., Bank I., Marcantonio E. The role of the I-domain in ligand binding of the human integrin α1β1. J. Biol. Chem. 269:1994;22811-22816.
26. Landis R., Bennett R., Hogg N. A novel LFA-1 activation epitope maps to the I-domain. J. Cell Biol. 120:1993;1519-1527.
27. Lasz E., McLane M., Trybulec M., Kowalska M., Khan S., et al. Beta 3 integrin derived peptide 217-230 inhibits fibrinogen binding and platelet aggregation: significance of RGD sequences and fibrinogen A alpha-chain. Biochem. Biophys. Res. Commun. 190:1993;118-124.
28. Lee J.-O., Rieu P., Arnaout M.A., Liddington R. Crystal structure of the A domain from the a subunit of integrin CR3 (CD11b/CD18). Cell. 80:1995;631-638.
29. 3 integrin mutation abolishes ligand induced binding and alters divalent cation-dependent conformation. Science. 249:1990;915-918.
30. Loftus J.C., Smith J.W., Ginsberg M.H. Integrin-mediated cell adhesion: the extracellular face. J. Biol. Chem. 269:1994;25235-25238.
31. Luque A., Gomez-Gutierrez M., Puzon W., Takada Y., Sanchez-Madrid F., Cabanas C. Activated conformations of VLA integrins detected by a group of antibodies specific for a novel regulatory region (355-425) of the common β1 chain. J. Biol. Chem. 271:1996;11067-11075.
32. Michishita M., Videm V., Arnaout M.A. A novel divalent cation-binding site in the A domain of the β2 integrin CR3 (CD11b/CD18) is essential for ligand binding. Cell. 72:1993;857-867.
33. Miyamoto S., Akiyama S.K., Yamada K.M. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science. 267:1995;883-885.
34. Miyamoto S., Teramoto H., Coso O.A., Gutkind J.S., Burbelo P.D., et al. Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules. J. Cell Biol. 131:1995;791-805.
35. Mould A., Akiyama S., Humphries M. The inhibitory anti-β1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy: evidence for allosteric inhibition of integrin function. J. Biol. Chem. 271:1996;20365-20374.
36. Mould A.P., Askari J.A., Aota S.I., Yamada K.M., Irie A., Takada Y., Mardon H.J., Humphries M.J. Defining the topology of integrin α5β1-fibronectin interactions using inhibitory anti-α5 and anti-β1 monoclonal antibodies: Evidence that the synergy sequence of fibronectin is recognized by the N-terminal repeats of the α5 subunit. J. Biol. Chem. 272:1997;17283-17292.
37. Muchowski P.J., Zhang L., Chang E.R., Soule H.R., Plow E.F., Moyle M. Functional interaction between the integrin antagonist neutrophil inhibitory factor and the I-domain of CD11b/CD18. J. Biol. Chem. 269:1994;26419-26423.
38. Pasqualini R., Koivunen E., Ruoslahti E. A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins. J. Cell Biol. 130:1995;1189-1196.
39. Puzon-McLaughlin W., Takada Y. Critical residues for ligand binding in the integrin b1 subunit. J. Biol. Chem. 271:1996;20438-20443.
40. Puzon-McLaughlin W., Yednock T., Takada Y. Regulation of conformation and ligand binding function of integrin α5β1 by the β1 cytoplasmic domain. J. Biol. Chem. 271:1996;16580-16585.
41. Qu A., Leahy D.J. Crystal structure of the I-domain of the CD11a/CD18 (LFA-1, αLβ2) integrin. Proc. Natl. Acad. Sci. USA. 92:1995;10277-10281.
42. Randi A.M., Hogg N. I-domain of β2 integrin lymphocyte function associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1. J. Biol. Chem. 269:1994;12395-12398.
43. Rieu P., Ueda T., Haruta I., Sharma C.P., Arnaout M.A. The A-domain of β2 integrin CR3(CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF. J. Cell Biol. 127:1994;2081-2091.
44. Ruoslahti E. Integrins. J. Clin. Invest. 87:1991;1-7.
45. Schiffer S., Hemler M., Lobb R., Tizard R., Osborn L. Molecular mapping of functional antibody binding sites of α4 integrin. J. Biol. Chem. 270:1995;14270-14273.
46. Smith J.W., Cheresh D.A. Integrin (αVβ3) ligand interaction: Identification of a divalent cation-dependent heterodimeric RGD binding site on the vitronectin receptor. J. Biol. Chem. 265:1990;2168-2172.
47. Springer T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 76:1994;301-314.
48. Springer T. Folding of the N-terminal, ligand binding region of integrin α subunits into a β-propeller domain. Proc. Natl. Acad. Sci. USA. 94:1997;65-72.
49. Steiner B., Trzeciak A., Pfenninger G., Kouns W. Peptides derived from a sequence within beta 3 integrin bind to platelet alpha IIb beta 3 (GPIIb-IIIa) and inhibit ligand binding. J. Biol. Chem. 268:1993;6870-6873.
50. Takada Y., Puzon W. Identification of a regulatory region of integrin β1 subunit using activating and inhibiting antibodies. J. Biol. Chem. 268:1993;17597-17601.
51. Takada Y., Ylänne J., Mandelman D., Puzon W., Ginsberg M. A point mutation of integrin β1 subunit blocks binding of α5β1 to fibronectin and invasin but not recruitment to adhesion plaques. J. Cell Biol. 119:1992;913-921.
52. Takagi J., Isobe T., Takada Y., Saito Y. Structural interlock between ligand-binding site and stalk-like region of β1 integrin revealed by a monoclonal antibody recognizing conformation-dependent epitope. J. Biochem. 121:1997;914-921.
53. Takagi J., Kamata T., Meredith J., Puzon-McLaughlin W., Takda Y. Changing ligand specificities of αvβ1 and αvβ3 integrins by swapping a short diverse sequence of β subunit. J. Biol. Chem. 272:1997;19794-19800.
54. Tozer E., Liddington R., Sutcliffe M., Smeeton A., Loftus J. Ligand binding to integrin αIIbβ3 is dependent on a MIDAS like domain in the β3 subunit. J. Biol. Chem. 271:1996;21978-21984.
55. Tuckwell D., Calderwood D.A., Green L.J., Humphries M.J. Integrin β2 I-domain is a binding site for collagens. J. Cell Sci. 108:1995;1629-1637.
56. Tuckwell D., Humphries M. A structure prediction for the ligand-binding region of the integrin β subunit: evidence for the presence of a von Willebrand factor A domain. FEBS Lett. 400:1997;297-303.
57. Ueda T., Rieu P., Brayer J., Arnaout M.A. Identification of the complement iC3b binding site in the β2 integrin CR3 (CD11b/CD18). Proc. Natl. Acad. Sci. USA. 91:1994;10680-10684.
58. Yamada K.M. Adhesive recognition sequences. J. Biol. Chem. 266:1991;12809-12812.
59. Yamada K.M., Miyamoto S. Integrin transmembrane signaling and cytoskeletal control. Curr. Opin. Cell Biol. 7:1995;681-689.
60. Yednock T.A., Cannon C., Vandevert C., Goldbach E.G., Shaw G., et al. α4β1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand. J. Biol. Chem. 270:1995;28740-28750.
61. Zhou L., Lee D.H.S., Plescia J., Lau C.Y., Altieri D.C. Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domain. J. Biol. Chem. 269:1994;17075-17079.