Chromosomal instability and telomere length variations during the life span of human fibroblast clones

Experimental Cell Research

Volumn 236, Issue 2, 1997, Pages 385-396

  Mondello, Chiara ^a   Riboni, Roberta ^a   Casati, Alessandra ^a   Nardo, Tiziana ^a   Nuzzo, Fiorella ^a  

^a Ist Genet Biochim ed E   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL SURVIVAL; FIBROBLAST; GENETIC STABILITY; HUMAN; HUMAN CELL; KARYOTYPE; LIFESPAN; PRIORITY JOURNAL; SENESCENCE; TELOMERE;

EID: 0031281380     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1997.3756     Document Type: Article

References (42)

1. Goldstein S. Replicative senescence: The human fibroblast comes of age. Science. 249:1990;1129-1250.
2. Wright W. E., Shay J. W. Telomere positional effects and the regulation of cellular senescence. TIG. 8:1992;193-197.
3. Ray F. A., Peabody D. S., Cooper J. L., Cram L. S., Kraemer P. M. SV40 T antigenalone. J. Cell. Biochem. 42:1990;13-31.
4. Stewart N., Bacchetti S. Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells. Virology. 180:1991;49-57.
5. Sandberg A. A. The Chromosomes in Human Cancer and Leukemia. 1990;Elsevier, New York.
6. Mitelman F., Mertens F., Johansson B. A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nature Genet. 15:1997;417-474.
7. Benn P. A. Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos. Am. J. Hum. Genet. 28:1976;465-473.
8. Hastie N. D., Allshire R. C. Human telomeres: Fusion and interstitial site. TIG. 5:1989;326-331.
9. Counter C. M., Avilion A. A., LeFeuvre C. E., Stewart N. G., Greider C. W., Harley C. B., Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1992;1921-1929.
10. Harley C. B., Futcher A. B., Greider C. W. Telomeres shorten during ageing of human fibroblasts. Nature. 345:1990;458-460.
11. Lindsey J., McGill N. I., Lindsey L. A., Green D. K., Cooke H. J. In vivo. Mutat. Res. 256:1991;45-48.
12. Allsopp R. C., Vaziri H., Patterson C., Goldstein S., Younglai E. V., Futcher A. B., Greider C. W., Harley C. B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA. 89:1992;10114-10118.
13. Allsopp R. C., Chang E., Kashefi-Aazam M., Rogaev E. I., Mieczyslaw A. P., Shay J. W., Harley C. B. Telomere shortening is associated with cell divisionin vitroin vivo. Exp. Cell Res. 220:1995;194-200.
14. Zakian V. A. Structure and function of the telomeres. Annu. Rev. Genet. 23:1989;579-604.
15. Blackburn E. H. Structure and function of telomeres. Nature. 350:1991;569-573.
16. de Lange T. Activation of telomerase in a human tumor. Proc. Natl. Acad. Sci. USA. 91:1994;2882-2885.
17. Sawyer J. R., Roloson G. J., Bell J. M., Thomas J. R., Teo C., Chadduck W. M. Telomeric associations in the progression of chromosome aberrations in pediatric solid tumors. Cancer Genet. Cytogenet. 90:1996;1-13.
18. Riboni R., Casati A., Nardo T., Zaccaro E., Ferretti L., Nuzzo F., Mondello C. Telomeric fusions in cultured human fibroblasts as a source of genomic instability. Cancer Genet. Cytogenet. 95:1997;130-136.
19. Cleaver J. E., Kraemer K. H. Xeroderma pigmentosum. The Metabolic Basis of Inherited Disease. 1989;McGraw-Hill, New York. p. 2949-2971.
20. Nuzzo F., Lagomarsini P., Casati A., Giorgi R., Berardesca E., Stefanini M. Clonal chromosome rearrangements in a fibroblast strain from a patient affected by xeroderma pigmentosum (complementation group C). Mutat. Res. 219:1989;209-215.
21. Casati A., Stefanini M., Giorgi R., Ghetti P., Nuzzo F. Chromosome rearrangements in normal fibroblasts from xeroderma pigmentosum homozygotes and heterozygotes. Cancer Genet. Cytogenet. 51:1991;89-101.
22. McCormick J. J., Maher V. M. Towards an understanding of the malignant transformation of diploid human fibroblasts. Mutat. Res. 199:1988;273-291.
23. McCormick J. J., Kateley-Kohler S., Watanabe M., Maher V. M. Abnormal sensitivity of fibroblasts from xeroderma pigmentosum variants to transformation to anchorage independence by ultraviolet irradiation. Cancer Res. 7:1986;489-492.
24. Mondello C., Casati A., Riboni R., Nuzzo F. Structural instability of a transmissible end-to-end dicentric chromosome in a xeroderma pigmentosum fibroblast clone. Cancer Genet. Cytogenet. 79:1995;41-48.
25. Sutherland B. M., Cimino J. S., Delihas N., Shih A. G., Oliver R. P. Ultraviolet light-induced transformation of human cells to anchorage-independent growth. Cancer Res. 40:1980;1934-1939.
26. Maher V. M., Rowan L. A., Silinskas K. C., Kateley S. A., McCormick J. J. Frequency of UV-induced neoplastic transformation of diploid fibroblasts is higher in xeroderma pigmentosum cells than in normal cells. Proc. Natl. Acad. Sci. USA. 79:1982;2613-2617.
27. Boyer J. C., Kaufmann W. K., Cordeiro-Stone M. Role of postreplication repair in transformation of human fibroblasts to anchorage independence. Cancer Res. 51:1991;2960-2964.
28. Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning. A Laboratory Manual. 1989;Cold Spring Harbor Press, Cold Spring Harbor. p. 6.53-6.54.
29. Bertoni L., Attolini C., Tessera L., Mucciolo E., Giulotto E. Telomeric and nontelomeric (TTAGGG)n. Genomics. 24:1994;53-62.
30. Casati A., Riboni R., Caprioli J., Nuzzo F., Mondello C. Condensation anomalies and exclusion in micronuclei of rearranged chromosomes in human fibroblasts culturedin vitro. Chromosoma. 104:1995;137-142.
31. Kano Y., Little J. B. Mechanisms of human cell neoplastic transformation: Relationship of specific abnormal clone formation to prolonged lifespan in X-irradiated human diploid fibroblasts. Int. J. Cancer. 36:1985;407-413.
32. Ide T., Tsuji Y., Nakashima T., Ishibashi S. Progress of aging in human diploid cells transformed with a tsA mutant of Simian virus 40. Exp. Cell Res. 150:1984;321-328.
33. Stein G. H. Coordinate control of growth arrest states in normal human diploid fibroblasts: Effect of cloned SV40 tumor antigen genes. Exp. Cell Res. 184:1989;297-303.
34. Smith J. R., Whitney R. G. Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging. Science. 207:1980;82-84.
35. Allsopp R. C., Harley C. B. Evidence for a critical telomere length in senescent human fibroblasts. Exp. Cell Res. 219:1995;130-136.
36. Sherwood S. W., Rush D., Ellsworth J. L., Schimke R. T. Defining cellular senescence in IMR-90 cells: A flow cytometric analysis. Proc. Natl. Acad. Sci. USA. 85:1988;9086-9090.
37. Harley C. B., Villeponteau B. Telomeres and telomerase in aging and cancer. Curr. Opin. Genet. Dev. 5:1995;249-255.
38. Metcalfe J. A., Parkhill J., Campbell L., Stacey M., Biggs P., Byrd P. J., Taylor A. M. R. Accelerated telomere shortening in ataxia telangiectasia. Nature Genet. 13:1997;350-357.
39. Henderson S., Allsopp R., Spector D., Wang S., Harley C. In situ. J. Cell Biol. 134:1996;1-12.
40. Lansdorp P. M., Verwoerd N. P., van de Rijke F. M., Dragowska V., Little M.-T., Dirks R. W., Raap A. K., Tanke H. J. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5:1996;685-691.
41. Greenblatt M. S., Bennett W. P., Hollstein M., Harris C. C. Mutations in thep53. Cancer Res. 54:1994;4855-4878.
42. Smith J. R., Pereira-Smith O. M. Replicative senescence: implications forin vivo. Science. 273:1996;63-67.