Metathesis of aniline and 1,2-dihydroquinoline derivatives

Tetrahedron Letters

Volumn 40, Issue 28, 1999, Pages 5247-5250

  Evans, Paul ^a   Grigg, Ronald ^a   Monteith, Michael ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIHYDROQUINOLINE DERIVATIVE; ANILINE; ANILINE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRROLINE DERIVATIVE; QUINOLINE DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

EID: 0033538639     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00993-4     Document Type: Article

References (27)

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21. a of anilines in: Perrin, D. D. IUPAC Dissociation Constants of Organic Bases in Aqueous Solution, Butterworths, London (1965); supplement: Perrin, D. D. WPAC Dissociation Constants of Organic Bases in Aqueous Solution-supplement, Butterworths, London (1972).
22. a of anilines in: Perrin, D. D. IUPAC Dissociation Constants of Organic Bases in Aqueous Solution, Butterworths, London (1965); supplement: Perrin, D. D. WPAC Dissociation Constants of Organic Bases in Aqueous Solution-supplement, Butterworths, London (1972).
23. +, 100%).
24. Synthesis of starting materials: RCM precursors 2a, 2c to 2l were synthesised from commercially available anilines with allyl bromide. 2b was prepared following initial treatment of 2-iodoaniline with 4-bromo-1-butene, then conversion of the initial monoalkylated aniline to 2b with allyl bromide. 4 was prepared from 8-methyl quinoline by allyl Grignard addition and allyl bromide quench.
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