Synthesis of 2'-C-α-difluoromethylarauridine and its 3'-O- phosphoramidite incorporation into a hammerhead ribozyme

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 5, 1999, Pages 787-792

  Dunkel, Martin ^a,b,d   Reither, Vivian ^a,c,d  

^a Innovir GmbH   (Germany)

^b Nigu Chemie GmbH   (Germany)

^c ALTANA PHARMA AG   (Germany)

^d VIMRX Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLEVUDINE; HYDROXYL GROUP; MAGNESIUM ION; PHOSPHORAMIDIC ACID DERIVATIVE; RIBONUCLEASE; RIBOZYME; URIDINE;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; DEGRADATION; HYDROGEN BOND; POLYACRYLAMIDE GEL ELECTROPHORESIS; REACTION ANALYSIS; SEQUENCE ANALYSIS; STEREOCHEMISTRY; SYNTHESIS;

ANIMALS; BASE SEQUENCE; CATALYSIS; ENZYME STABILITY; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC; SHARKS; URIDINE;

EID: 0033535404     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00063-3     Document Type: Article

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