Modulation of nociception by microinjection of Delta-1 and Delta-2 opioid receptor ligands in the ventromedial medulla of the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 3, 1997, Pages 1185-1192

  Thorat, Sanjay N ^a   Hammond, Donna L ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 BENZYLIDENENALTREXONE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; DELTA OPIATE RECEPTOR ANTAGONIST; DELTORPHIN[2 DEXTRO ALANINE 4 GLUTAMINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; NALTRIBEN; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HOT PLATE TEST; INTRACEREBRAL DRUG ADMINISTRATION; LATENT PERIOD; MALE; MEDULLA OBLONGATA; NEUROMODULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; TAIL FLICK TEST; TISSUE DISTRIBUTION;

ANALGESICS, OPIOID; ANIMALS; BENZYLIDENE COMPOUNDS; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; NALTREXONE; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA;

EID: 0031456984     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. ADAMS, J. U., TALLARIDA, R. J., GELLER, E. B. AND ADLER, M. W.: Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonists and the analgesic assay used. J. Pharmacol. Exp. Ther. 266: 1261-1267, 1993.
2. ARVIDSSON, U., DADO, R. J., RIEDL, M., LEE, J.-H., LAW, P. Y., LOH, H. H., ELDE, R. AND WESSENDORF, M. W.: δ-Opioid receptor immunoreactivity: Distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin. J. Neurosci. 15: 1215-1235, 1995a.
3. ARVIDSSON, U., RIEDL, M., CHAKRABARTI, S., LEE, J.-H., NAKANO, A. H., DADO, R. J., LOH, H. H., LAW, P.-Y., WESSENDORF, M. W. AND ELDE, R.: Distribution and targeting of a μ-opioid receptor (MOR1) in brain and spinal cord. J. Neurosci. 15: 3328-3341, 1995b.
4. DROWER, E. J. AND HAMMOND, D. L.: GABAergic modulation of nociceptive threshold: Effects of THIP and bicuculline microinjected in the ventral medulla of the rat. Brain Res. 450: 316-324, 1988.
5. FINLEY, J. C. W., MADERDRUT, J. L. AND PETRUSZ, P.: The immunocytochemical localization of enkephalin in the central nervous system of the rat. J. Comp. Neurol. 198: 541-565, 1981.
6. FINNEY, D. J.: Statistical Method in Biological Assay. Hafner Publishing Co., New York, 1964, pp. 668.
7. GEBHART, G. F.: Opiate and opioid peptide effects on brain stem neurons: Relevance to nociception and antinociceptive mechanisms. Pain 12: 93-140, 1982.
8. GEBHART, G. F.: Descending modulation of spinal nociceptive processing. Der Schmerz 7: 216-225, 1993.
9. HAMMOND, D. L.: Control systems for nociceptive afferent processing: The descending inhibitory pathways. In Spinal Afferent Processing, ed. by T. L. Yaksh. pp. 363-390, Plenum, New York, 1986.
10. HAMMOND, D. L.: Pharmacological Mechanisms of Pain Modulation: An update on δ opioid receptors. In Current and Emerging Issues in Cancer Pain: Research and Practice, ed. by C. R. Chapman and K. M. Foley, pp. 175-183, Raven Press, Ltd., New York, 1993.
11. HAMMOND, D. L., LEVY, R. A. AND PROUDFIT, H. K.: Hypoalgesia following microinjection of noradrenergic antagonists in the nucleus raphe magnus. Pain 9: 85-101, 1980.
12. HAMMOND, D. L., STEWART, P. E. AND LITTELL, L.: Antinociception and delta-1 opioid receptors in the rat spinal cord: Studies with intrathecal 7-benzylidenenaltrexone. J. Pharmacol. Exp. Ther. 274: 1317-1324, 1995.
13. HEINRICHER, M. M., HAWS, C. M. AND FIELDS, H. L.: Evidence for GABA-mediated control of putative nociceptive modulating neurons in the rostral ventromedial medulla: Iontophoresis of bicuculline eliminates the off-cell pause. Somatosens. Motor Res. 8: 215-225, 1991.
14. HEYMAN, J. S., MULVANEY, S. A., MOSBERG, H. I. AND PORRECA, F.: Opioid δ-receptor involvement in supraspinal and spinal antinociception in mice. Brain Res. 420: 100-108, 1987.
15. JANG, J., YAKSH, T. L. AND HILL, H. F.: Use of 2-hydroxypropyl-β-cyclodextrin as an intrathecal drug vehicle with opioids. J. Pharmacol. Exp. Ther. 261: 592-600, 1992.
16. JENSEN, T. S. AND YAKSH, T. L. III: Comparison of the antinociceptive action of mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique. Brain Res. 372: 301-312, 1986.
17. 6)enkephalin and naltrindole 5′-isothiocyanate: Evidence of delta receptor subtypes. J. Pharmacol. Exp. Ther. 257: 1069-1075, 1991.
18. JONES, S. L.: Descending control of nociception. In The Initial Processing of Pain and Its Descending Control: Spinal and Trigeminal Systems, ed. by A. R. Light, pp. 201-195, Karger, Basel, 1992.
19. KALYUZHNY, A. E., ARVIDSSON, U., WU, W. AND WESSENDORF, M. W.: μ-Opioid and δ-opioid receptors are expressed in brainstem antinociceptive circuits: Studies using immunocytochemistry and retrograde tract-tracing. J. Neurosci. 16: 6490-6503, 1996.
20. KHACHATURIAN, H., LEWIS, M. E. AND WATSON, S. J.: Enkephalin systems in diencephalon and brainstem of the rat. J. Comp. Neurol. 220: 310-320, 1983.
21. MALMBERG, A. B. AND YAKSH, T. L.: Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: Effects of naltrindole and its benzofuran analog (NTB). J. Pharmacol. Exp. Ther. 263: 264-275, 1992.
22. MANSOUR, A., FOX, C. A., BURKE, S., MENG, F., THOMPSON, R. C., AKIL, H. AND WATSON, S. J.: Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. J. Comp. Neurol. 350: 412-438, 1994.
23. MANSOUR, A., KHACHATURIAN, H., LEWIS, M. E., AKIL, H. AND WATSON, S. J.: Anatomy of CNS opioid receptors. Trends Neurol. Sci. 11: 308-314, 1988.
24. MATTIA, A., FARMER, S. C., TAKEMORI, A. E., SULTANA, M., PORTOGHESE, P. S., MOSBERG, H. I., BOWEN, W. D. AND PORRECA, F.: Spinal opioid delta antinociception in the mouse: Mediation by a 5′-NTII-sensitive delta receptor subtype. J. Pharmacol. Exp. Ther. 260: 518-525, 1992.
25. 2]deltorphin II in mice: Evidence for delta receptor subtypes. J. Pharmacol. Exp. Ther. 258: 583-587, 1991.
26. MIASKOWSKI, C., TAIWO, Y. O. AND LEVINE, J. D.: Contribution of supraspinal muand delta-opioid receptors to antinociception in the rat. Eur. J. Pharmacol. 205: 247-252, 1991.
27. NEGRI, L., NOVIELLO, V. AND ANGELUCCI, F.: Behavioural effects of deltorphins in rats. Eur. J. Pharmacol. 209: 163-168, 1991.
28. OSSIPOV, M. H., KOVELOWSKI, C. J., NICHOLS, M. L., HRUBY, V. J. AND PORRECA, F.: Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat. Pain 62: 287-293, 1995.
29. PORRECA, F. AND BURKS, T. F.: Supraspinal opioid receptors in antinociception. In Opioids II, ed. by A. Herz, pp. 21-51, Springer-Verlag, Berlin, 1993.
30. RIVLIN, A. S. AND TATOR, C. H.: Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J. Neurosurg. 47: 577-581, 1977.
31. ROERIG, S. C. AND FUJIMOTO, J. M.: Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice. J. Pharmacol. Exp. Ther. 249: 762-768, 1989.
32. ROSSI, G. C., PASTERNAK, G. W. AND BODNAR, R. J.: μ And δ opioid synergy between the periaqueductal gray and the rostro-ventral medulla. Brain Res. 665: 85-93, 1994.
33. ROYCHOWDHURY, S. AND FIELDS, H. L.: Endogenous opioids acting at a medullary μ-opioid receptor contribute to the behavioral antinociception produced by GABA antagonism in the midbrain periaqueductal gray Neuroscience 74: 863-872, 1996.
34. SAEKI, S. AND YAKSH, T. L.: Suppression of nociceptive responses by spinal mu opioid agonists: Effects of stimulus intensity and agonist efficacy. Anesth. Analg. 77: 265-274, 1993.
35. SOFUOGLU, M., PORTOGHESE, P. S. AND TAKEMORI, A. E.: Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: Evidence for delta opioid receptor subtypes. J. Pharmacol. Exp. Ther. 257: 676-680, 1991.
36. STAPELFELD, A., HAMMOND, D. L. AND RAFFERTY, M. F.: Antinociception after intracerebroventricular administration of naltrindole in the mouse. Eur. J. Pharmacol. 214: 273-276, 1992.
37. 4]deltorphin. J. Pharmacol. Exp. Ther. 266: 820-828, 1993.
38. STEWART, P. E. AND HAMMOND, D. L.: Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat. J. Pharmacol. Exp. Ther. 268: 701-708, 1994.
39. 2 opioid receptor subtypes. Life Sci. 55: PL79-84, 1994.
40. 2-opioid receptors in the brain and spinal cord respectively. Eur. J. Pharmacol. 242: 145-150, 1993.
41. TAKEMORI, A. E., SOFUOGLU, M., SULTANA, M., NAGASE, H. AND PORTOGHESE, P. S.: Pharmacology of highly selective, non-peptide delta opioid receptor antagonists. In New Leads in Opioid Research, ed. by J. M. van Ree, pp. 277-278, Elsevier, New York, 1990.
42. TAKEMORI, A. E., SULTANA, M., NAGASE, H. AND PORTOGHESE, P. S.: Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone Life Sci. 50: 1491-1495, 1992.
43. THORAT, S. N. AND HAMMOND, D. L.: Antinociception produced by microinjection of delta opioid receptor agonists into the ventromedial medulla of the rat. Soc. Neurosci. Abstr. 22: 1364, 1996.
44. 2 opioid receptors in antinociception: Studies with subtype selective antagonists. Soc. Neurosci. Abstr. 23: 1019, 1997.
45. YAKSH, T. L., JANG, J., NISHIUCHI, Y., BRAUN, K. P., RO, S. AND GOODMAN, M.: The utility of 2-hydroxypropyl-β-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs. Life Sci. 48: 623-633, 1991.
46. ZAKI, P. A., BILSKY, E. J., VANDERAH, T. W., LAI, J., EVANS, C. J. AND PORRECA, F.: Opioid receptor subtypes: The δ receptor as a model. Annu. Rev. Pharmacol. Toxicol. 36: 379-401, 1996.
47. 8 and Leu-enkephalin in discrete regions of the rat brain. Brain Res. 326: 1-8, 1985.
48. ZHUO, M. AND GEBHART, G. F.: Characterization of descending inhibition and facilitation of spinal nociceptive transmission from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in rat. Pain 42: 337-350, 1990.
49. ZHUO, M. AND GEBHART, G. F.: Spinal serotonin receptors mediate descending facilitation of a nociceptive reflex from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Brain Res. 550: 35-48, 1991.