Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia

New England Journal of Medicine

Volumn 341, Issue 15, 1999, Pages 1106-1111

  Talley, Nicholas J ^a   Vakil, Nimish ^b   Ballard II, E David ^d   Fennerty, M Brian ^c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; CLARITHROMYCIN; OMEPRAZOLE;

ARTICLE; CHRONIC GASTRITIS; CONTROLLED STUDY; DYSPEPSIA; HELICOBACTER PYLORI; HUMAN; INFECTION CONTROL; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AMOXICILLIN; ANTI-BACTERIAL AGENTS; ANTI-ULCER AGENTS; CHRONIC DISEASE; CLARITHROMYCIN; DRUG THERAPY, COMBINATION; DYSPEPSIA; FEMALE; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; OMEPRAZOLE; QUALITY OF LIFE; TREATMENT OUTCOME;

EID: 0033533860     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199910073411502     Document Type: Article

References (26)

1. Talley NJ, Colin-Jones D, Koch KL, Koch M, Nyrén O, Stanghellini V. Functional dyspepsia: a classification with guidelines for diagnosis and management. Gastroenterol Int 1991;4:145-60.
2. Bernersen B, Johnsen R, Bostad L, Straume B, Sommer AI, Burhol PG. Is Helicobacter pylori the cause of dyspepsia? BMJ 1992;304:1276-9.
3. Armstrong D. Helicobacter pylori infection and dyspepsia. Scand J Gastroenterol Suppl 1996;215:38-47.
4. Richter JE. Dyspepsia: organic causes and differential characteristics from functional dyspepsia. Scand J Gastroenterol Suppl 1991;182:11-6.
5. Heikkinen M, Pikkarainen P, Takala J, Rasanen H, Julkunen R. Etiology of dyspepsia: four hundred unselected consecutive patients in general practice. Scand J Gastroenterol 1995;30:519-23.
6. Klauser AG, Voderholzer WA, Knesewitsch PA, Schindlbeck NE, Muller-Lissner SA. What is behind dyspepsia? Dig Dis Sci 1993;38:147-54.
7. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. Helicobacter pylori in peptic ulcer disease. JAMA 1994;272:65-9.
8. American Gastroenterological Association medical position statement: evaluation of dyspepsia. Gastroenterology 1998;114:579-81.
9. Hunt RH, Thompson ABR. Canadian Helicobacter pylori consensus conference. Can J Gastroenterol 1998;12:31-41.
10. Malfertheiner P, Megraud F, O'Morain C, et al. Current European concepts in the management of Helicobacter pylori infection - the Maastricht Consensus report. Eur J Gastroenterol Hepatol 1997;9:1-2.
11. Lam SK, Talley NJ. Report of the 1997 Asia Pacific Consensus Conference on the management of Helicobacter pylori infection. J Gastroenterol Hepatol 1998;13:1-12.
12. Talley NJ. A critique of therapeutic trials in Helicobacter pylori-positive functional dyspepsia. Gastroenterology 1994;106:1174-83.
13. Blum AL, Talley NJ, O'Morain C, et al. Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med 1998;339:1875-81.
14. McColl KEL, Murray LS, El-Omar E, et al. Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med 1998;339:1869-74.
15. McCarthy C, Patchett S, Collins RM, Beattie S, Keane C, O'Morain C. Long-term prospective study of Helicobacter pylori in nonulcer dyspepsia. Dig Dis Sci 1995;40:114-9.
16. Malaty HM, el-Zimaity HM, Genta RM, Klein PD, Graham DY. Twenty-minute fasting version of the US 13C-urea breath test for the diagnosis of H. pylori infection. Helicobacter 1996;1:165-7.
17. Svedlund J, Sjodin I, Dotervall G. GSRS - a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci 1988;33:129-34.
18. Talley NJ, Meineche-Schmidt V, Paré P, et al. Efficacy of omeprazole in functional dyspepsia: a double-blind, randomized, placebo-controlled trial. Aliment Pharmacol Ther 1998;12:1055-65.
19. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis: the updated Sydney system. Am J Surg Pathol 1996;20: 1161-81.
20. Mant JW, Jenkinson C, Murphy MF, Clipsham K, Marshall P, Vessey MP. Use of the Short Form-36 to detect the influence of upper gastrointestinal disease on self-reported health status. Qual Life Res 1998;7:221-6.
21. Leidy NK, Revicki DA, Genenté B. Recommendations for evaluating the validity of quality of life claims for labeling and promotion. Value Health 1999;2:113-27.
22. Ware JE Jr, Snow KK, Kosinski M, Gandek B. SF-36 health survey: manual and interpretation guide. Boston: The Health Institute, New England Medical Center, 1993.
23. Agresti A. Categorical data analysis. New York: Wiley, 1990.
24. Searle SR. Linear models. New York: Wiley, 1971.
25. Veldhuyzen van Zanten SJO, Cleary C, Talley NJ, et al. Drug treatment of functional dyspepsia: a systematic analysis of trial methodology with recommendations for design of future trials. Am J Gastroenterol 1996;91:660-73.
26. Talley NJ, Janssens J, Lauritsen K, Racz I, Bolling-Sternevald E. Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up. BMJ 1999;318: 833-7.