Diethylcarbamoylating/nitroxylating agents as dual action inhibitors of aldehyde dehydrogenase: A disulfiram-cyanamide merger

Journal of Medicinal Chemistry

Volumn 42, Issue 20, 1999, Pages 4016-4020

  Conway, Terry T ^a   DeMaster, Eugene G ^a   Goon, David J W ^a,c   Shirota, Frances N ^a   Nagasawa, Herbert T ^a,b  

^a VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c LecTec Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE INHIBITOR; CYANAMIDE; DIETHYLCARBAMOYLNITROXYL DERIVATIVE; DISULFIRAM; ETHOXYCARBONYL O (DIETHYLCARBAMOYL)BENZENESULFOHYDROXAMIC ACID; N (N,N DIETHYLCARBAMOYL) O METHYLBENZENESULFOHYDROXAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; INHIBITION KINETICS; MALE; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ACETALDEHYDE; ALCOHOL DETERRENTS; ALDEHYDE DEHYDROGENASE; ANIMALS; ENZYME INHIBITORS; ETHANOL; HYDROXAMIC ACIDS; MALE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; YEASTS;

EID: 0033533748     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990235p     Document Type: Article

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