A convenient method for the synthesis of N-free 5'-O-(p,p'- dimethoxytrityl)-2'deoxyribonucleosides via the 5'-O-selective tritylation of the parent substances

Journal of Organic Chemistry

Volumn 64, Issue 16, 1999, Pages 6087-6089

  Kataoka, Masanori ^a   Hayakawa, Yoshihiro ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5' O (4,4' DIMETHOXYTRITYL) 2' DEOXYRIBONUCLEOSIDE; DEOXYRIBONUCLEOSIDE; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REACTION TIME; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SYNTHESIS; TEMPERATURE;

EID: 0033529961     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo990051i     Document Type: Article

References (17)

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15. A multistep synthesis using an isobutyryl group in place of the amidine group for the protection of the nucleoside base has been also reported in ref 4, but this method gives the target product in a lower yield than does the amidine-protected method.
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17. Preparation of N-free 5′-O-monomethoxytrityl- and 5′-O-trityl-2′-deoxyribonucleosides was similarly achieved via the direct, chemoselective reaction of the parent substances using p-methoxytrityl chloride or trityl chloride, respectively.