Venezuelan equine encephalitis virus vectors expressing HIV-1 proteins: Vector design strategies for improved vaccine efficacy

Vaccine

Volumn 17, Issue 23-24, 1999, Pages 3124-3135

  Caley, Ian J ^a   Betts, Michael R ^b   Davis, Nancy L ^a   Swanstrom, Ronald ^a   Frelinger, Jeffrey A ^a   Johnston, Robert E ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

HIV 1 MA CA; Long term immune response; VEE; Viral vaccine vector

Indexed keywords

GLYCOPROTEIN; VIRUS PROTEIN; VIRUS VACCINE; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENCEPHALOMYELITIS; FREQUENCY ANALYSIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TARGET CELL; VIRUS EXPRESSION; VIRUS VIRULENCE;

AIDS VACCINES; ANIMALS; CAPSID; CELLS, CULTURED; CRICETINAE; ENCEPHALITIS VIRUS, VENEZUELAN EQUINE; FEMALE; GENETIC VECTORS; GENOME, VIRAL; HIV ANTIBODIES; HIV-1; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PROMOTER REGIONS (GENETICS); STEM CELLS; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, DNA; VIRAL MATRIX PROTEINS;

EID: 0033529617     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00142-5     Document Type: Article

References (31)

1. Murphy B.R., Chanock R.M. Immunization against virus disease. Fields B.N., Knipe D.M., Howley P.M. Fields Virology. 3rd ed. 1996;467-497 Lippincott-Raven Pub, Philadelphia.
2. Johnston R.E., Peters C.J. Alphaviruses. Fields B.N., Knipe D.M., Howley P.M. Fields Virology. 3rd ed. 1996;843-894 Lippincott-Raven Pub, Philadelphia.
3. Frolov I., Hoffman T.A., Pragai B.M., et al. Alphavirus-based expression vectors: Strategies and applications. Proc Natl Acad Sci USA. 93:1996;11371-11377.
4. Rice C.M. Animal virus expression vectors. Seminars in Virology. 3:1992;237-310.
5. Strauss J.H., Strauss E.G. The alphaviruses: gene expression, replication and evolution. Microbial Rev. 58:1994;491-562.
6. Xiong C., Levis R., Shen P., Schlesinger S., Rice C.M., Huang H. Sindbis virus: An efficient, broad host range vector for gene expression in animal cells. Science. 243:1989;1188-1191.
7. Berglund P., Sjöberg M., Garoff H., Atkins G.J., Sheahan B.J., Liljeström P. Semliki Forest virus expression system: production of conditionally infectious recombinant particles. BioTechnology. 11:1993;916-920.
8. Dryga S.A., Sviatchenko V.A., Mikriukova T.P., et al. Preparation and study of recombinant strains of Venezuelan equine encephalomyelitis virus expressing the PreS2-s gene of hepatitis B virus. Voprosy Virusologii. 41:1996;100-104.
9. Hahn C.S., Hahn Y.S., Braciale T.J., Rice C.M. Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation. Proc Natl Acad Sci USA. 89:1992;2679-2683.
10. Liljeström P., Garoff H. A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. BioTechnology. 9:1991;1356-1361.
11. Zhou X., Berglund P., Rhodes G., Parker S.E., Jondal M., Liljeström P. Self-replicating Semliki Forest virus RNA as recombinant vaccine. Vaccine. 12:1994;1510-1514.
12. Zhou X., Berglund P., Zhao H., Liljeström P., Jondal M. Generation of cytotoxic and humoral immune responses by nonreplicative recombinant Semliki Forest virus. Proc Natl Acad Sci USA. 92:1995;3009-3013.
13. Charles P.C., Brown K.W., Davis N.L., Hart M.K., Johnston R.E. Mucosal immunity induced by parenteral immunization with a live attenuated Venezuelan equine encephalitis vaccine candidate. Virology. 228:1997;153-160.
14. Grieder F.B., Davis N.L., Aronson J.A., et al. Specific restrictions in the progression of Venezuelan equine encephalitis virus-induced disease resulting from single amino acid changes in the glycoproteins. Virology. 206:1995;994-1006.
15. Davis N.L., Brown K.W., Greenwald G.F., et al. Attenuated mutants of Venezuelan encephalitis virus containing lethal mutations in PE2 cleavage signal combined with a second-site suppressor mutation in E1. Virology. 212:1995;102-110.
16. Jahrling P.B., Stephenson E.H. Protective efficacies of live attenuated and formaldehyde-inactivated Venezuelan equine encephalitis virus vaccines against aerosol challenge in hamsters. J Clin Microbiol. 19:1984;429-431.
17. Kinney R.M., Esposito J.J., Matthews J.H., et al. Recombinant vaccinia virus/Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge. J Virol. 62:1988;4697-4702.
18. Davis N.L., Brown K.W., Johnston R.E. A viral vaccine vector that expresses foreign genes in lymph nodes and protects against mucosal challenge. J Virol. 70:1996;3781-3787.
19. Caley I.J., Betts M.R., Irlbeck D.M., et al. Humoral, mucosal and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. J Virol. 71:1997;3031-3038.
20. Pushko P., Parker M., Ludwig G.V., Davis N.L., Johnston R.E., Smith J.F. Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo. Virology. 239:1997;389-401.
21. Levis R., Schlesinger S., Huang H.V. Promoter for Sindbis Virus RNA-dependent subgenomic RNA transcription. J Virol. 64:1990;1726-1733.
22. Raju R., Huang H.V. Analysis of Sindbis virus promoter recognition in vivo, using novel vectors with two subgenomic mRNA promoters. J Virol. 65:1991;2501-2510.
23. Pugachev K.V., Mason P.W., Shope R.E., Frey T.K. Double-subgenomic Sindbis virus recombinants expressing immunogenic proteins of Japanese encephalitis virus induce significant protection in mice against lethal JEV infection. Virology. 212:1995;587-594.
24. Davis N.L., Powell N., Greenwald G.F., et al. Attenuating mutations in the E2 glycoprotein gene of Venezuelan equine encephalitis virus: construction of single and multiple mutants in a full-length cDNA clone. Virology. 183:1991;20-31.
25. Hirsch M.S., Curran J. Human immunodeficiency viruses. Fields B.N., Knipe D.M., Howley P.M. Fields Virology. 3rd ed. 1996;1953-1975 Lippincott-Raven Pub, Philadelphia.
26. Ratner L., Fisher A., Jagodzinski L.L., Mitsuya H., Gallo R.C., Wong-Staal F. Complete nucleotide sequences of functional clones of the AIDS virus. AIDS Res Hum Retroviruses. 3:1987;57-69.
27. Davis N.L., Willis L.V., Smith J.F., Johnston R.E. In vitro synthesis of infectious Venezuelan equine encephalitis virus RNA from a cDNA clone: analysis of a viable deletion mutant. Virology. 171:1989;189-204.
28. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London). 227:1970;680-685.
29. Matsui M., Hioe C.E., Frelinger J.A. Roles of the six peptide-binding pockets of the HLA-A2 molecule in allorecognition by human cytotoxic T-cell clones. Proc Natl Acad Sci USA. 90:1993;674-678.
30. Haynes B.F., Pantaleo G., Fauci A.S. Towards an understanding of the correlates of protective immunity to HIV infection. Science. 271:1996;324-328.
31. Koup R.A., Safrit J.T., Cao Y., Andrews C.A., McLeod G., Borkowsky W., Farthing C., Ho D.D. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol. 68:1994;4650-4655.