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While the term "Pauson - Khand reaction" applies, strictly speaking, only to Co-mediated process, the term "Pauson - Khand type reaction" refers to any analogous reaction mediated or catalyzed by a transition metal.
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The metallacyclopentene derived from the enyne in entry 10 was prepared and identified in an NMR tube reaction. The use of excess enyne was necessary to ensure clean and efficient metallacycle formation. Therefore, it is difficult to assign all the peaks for the metallacycle, but its presence and diastereomeric purity are clearly indicated by a single set of four indenyl doublets: δ 6.78 (J = 2.75 Hz, 1 H); 6.55 (J = 2.75 Hz, 1 H); 4.79 (J = 1.83 Hz, 1 H); 4.61 (J = 1.83 Hz, 1 H).
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The diastereoselective cyclization of an enyne by the rac-(EBTHI) moiety serves as an accurate model for the enantioselective cyclization of an enyne by the (S,S)-(EBTHI) moiety.
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