RIPs: An emerging family of kinases involved in pro-inflammatory and apoptotic signaling

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 64, Issue , 1999, Pages 359-362

  Dixit, V M ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; FAS ANTIGEN; PHOSPHOTRANSFERASE; TUMOR NECROSIS FACTOR RECEPTOR; CASPASE 9; FAS ASSOCIATED DEATH DOMAIN PROTEIN; I KAPPA B KINASE BETA; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; COMPLEX FORMATION; CONFERENCE PAPER; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME MECHANISM; GENE OVEREXPRESSION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; ARTICLE; BIOCHEMICAL ANALYSIS; DEATH EFFECTOR DOMAIN; INFLAMMATION; NONHUMAN; PROTEIN DEPHOSPHORYLATION;

EID: 0033511610     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1999.64.359     Document Type: Conference Paper

References (14)

1. Ashkenazi A. and Dixit V.M. 1998. Death receptors: Signaling and modulation. Defence 281: 1305.
2. Hofmann K., Bucher P., and Tschopp J. 1997. The CARD domain: A new apoptotic signaling motif. Trends Biochem. Sci. 22: 155.
3. Hsu H., Huang J., Shu H.-B., Baichwal V., and Goeddel D.V. 1996. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4: 387.
4. Inohara N., del Peso L., Koseki T., Chen S., and Nunez G. 1998. RICK: A novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J. Biol. Chem. 273: 12296.
5. Kelliher M.A., Grimm S., Ishida Y., Kuo F., Stanger B.Z., and Leder P. 1998. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8: 297.
6. McCarthy J.V., Ni J., and Dixit V.M. 1998. RIP2 is a novel NF-κB-activating and cell death-inducing kinase. J. Biol. Chem. 273: 16968.
7. Muzio M., Natoli G., Saccani S., Levrero M., and Mantovani A. 1998. The human toll signaling pathway: Divergence of nuclear factor κB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J. Exp. Med. 187: 2097.
8. Salvesen G.S. and Dixit V.M. 1997. Caspases: Intracellular signaling by proteolysis. Cell 91: 443.
9. Stanger B.Z., Leder P., Lee T.-H., Kim E., and Seed B. 1995. RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81: 513.
10. Sun X., Lee J., Navas T., Baldwin D.T., Stewart T.A., and Dixit V.M. 1999. RIP3, a novel apoptosis-inducing kinase. J. Biol. Chem. 274: 16871.
11. Thome M., Hofmann K., Burns K., Martins F., Bodmer J.-L., Mattmann C., and Tschopp J. 1998. Identification of CAR-DIAK, a RIP-Iike kinase that associates with caspase-1. Curr. Biol. 8: 885.
12. Van Antwerp D.J., Martin S.J., Verma I.M., and Green D.R. 1998. Inhibition of TNF-induced apoptosis by NF-κB. Trends Cell Biol. 8:107.
13. Yeh W.-C., Shahinian A., Speiser D., Kraunus J., Billia F., Wakeham A., de la Pompa J.L., Ferrick D., Hum B., Iscove N., Ohashi P., Rothe M., Goeddel D.V., and Mak T.W. 1997. Early lethality, functional NF-κB activation and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 7: 715.
14. Yu P.W., Huang B.C.B., Shen M., Quast J., Chan E., Xu X., Nolan O.P., Payan D.O., and Luo Y. 1999. Identification of RIP3, a RIP-like kinase that activates apoptosis and NF-κB. Curr. Biol. 9: 539.